Thiazole Formation Research Articles

Thiazole formation via traceless cleavage of Rink resin

The traceless cleavage of Rink amide resin to form thiazoles has been achieved using commercially available reagents. Conversion of Rink amide species to thioamides by use of Lawesson’s reagent prepares the resin bound substrates for traceless cleavage. Cleavage using limiting amounts of α-haloketones provides thiazole bearing compounds of high purity.

Azole series. I. Reaction of 2-(acylamino)thioacetamides, leading to 5-aminothiazoles and to thiazolo[5,4-d]pyrimidines.

Formation of 5-acetamido-substituted thiazoles was found to be readily effective on heating 2-(acylamino)thioacetamides with acetic anhydride. In additon, preparation of some starting 2-(acylamino)thioacetamides is described and 5-acetamidothiazole-4-carboxamides obtained by the thiazole formation reaction were led to some thiazolo[5, 4-d]pyrimidines.

123. Thiazole and thiadiazine formation from thiosemicarbazones

123. Thiazole and thiadiazine formation from thiosemicarbazones