AbstractThis research focuses on the heat source/sink, chemical reaction, and thermophoretic particle deposition in the influence of hybrid nanofluid over a moving thin needle subjected to a magnetic field. Using the appropriate transformations, a group of nonlinear partial differential equations may be converted to ordinary differential equations. Additionally, with the aid of computational software, the RKF‐45 approach is used for the numerical assessment, as well as the shooting operation. It should be mentioned that the results' approval demonstrates a strong association with the previous findings. The resulting graphs mainly explain the fundamental characteristics of hybrid nanofluids and nanofluids, as well as the consequences of different restrictions. An increase in needle size enhances the velocity profile, temperature profile, and concentration profile. The radial and axial velocity profiles are reduced when the magnetic constraint is increased, whereas the thermal and concentration patterns are reversed. Improved heat source‐sink as well as Biot number values will enhance the thermal profile. The concentration profiles will decrease due to reaction rate restrictions and thermophoretic limits. The inclusion of solid volume fraction reduces surface drag forces while increasing the rate of mass transfer. In most circumstances, hybrid nanofluid plays a prominent role than nanofluid.