Catalytic degradation of 2- nitroaniline is carried out under a penetrative flow and circular cross flow model as well as in the static state by a novel thermo-responsive catalytic membrane prepared by inserting Pd nanoparticles decorated thermo-responsive microgels into PVDF membrane pores. Due to the special thermo-responsive behavior of the catalytic membrane, increasing the temperature of the penetrative flow degradation from 30 to 35℃ can make the flux increase by at least 30 % and simultaneously the conversion increase by at least 0.3 %, significantly enhancing the reaction efficiency and the product discharge. In addition, the circular cross flow degradation shows a much higher rate than the static degradation. In brief, this membrane can well execute the catalytic degradation with side reactions and timely remove the products by the penetrative flow. Further more, the catalytic membrane can also well execute the catalytic degradation without side reactions by the circular cross flow.