The knowledge of process parameters–weld integrity-aging treatments–tensile property relationship is of great concern for linear friction welded (LFWed) Ti2AlNb-based alloy and requires a systematic characterization. Thus, the Ti2AlNb-based alloy was LFWed under various process parameters and then subjected to different aging treatments. Twelve welding conditions were used to evaluate the weld integrity, showing that impurities and cracks at weld interface can be eliminated under strong welding parameters and the feed rate has the greatest influence on the weld integrity among all process parameters. Relationships among aging temperatures, microstructure evolution, and mechanical properties were investigated. After aging treatment, acicular O phase has precipitated in B2 grains both in the weld zone and thermo-mechanical affected zone (TMAZ). The size of precipitated O phase increases along with the increase of temperature, and the α2 + O mixtures have finally decomposed into the aggregated acicular O phase. The microhardness and tensile strength of the joints have been enhanced due to the precipitation hardening of O phase and refined grain strengthening after aging treatments.