Despite the surging interest in the interactions between toxicants and non-chemical stressors, and in evolutionary ecotoxicology, we have poor knowledge whether these patterns differ among genotypes within a population. Warming and toxicants are two widespread stressors in aquatic systems that are known to modify each other's effects. We studied to what extent effects of sequential exposure to a heat spike and the pesticide esfenvalerate differed among genotypes in the water flea Daphnia magna. Esfenvalerate had similar negative effects on survival and body size across genotypes, and for most genotypes it increased time to maturation, yet the effects on the reproductive performance were only detected in some genotypes and were inconsistent in direction. Across genotypes, the heat spike increased the heat tolerance, yet the negative effects of the heat spike on survival, reproductive performance and body size, and the positive effects on grazing rate and the shortened time to maturation were only seen in some genotypes. Notably, the interaction type between both stressors differed among genotypes. In contrast to our expectation, the impact of esfenvalerate was only magnified by the heat spike in some genotypes and only for a subset of the traits. For survival and time to maturation, the interaction type for the same stressor combination covered all three categories: additions, synergisms and antagonisms. This illustrates that categorizing the interaction type between stressors at the level of populations may hide considerable intrapopulation variation among genotypes. Opposite to our expectation, the more pesticide-tolerant genotypes showed a stronger synergism between both stressors. Genotype-dependent interaction patterns between toxicants and non-chemical stressors may explain inconsistencies among studies and challenges ecological risk assessment based on single genotypes. The observed genetic differences in the responses to the (combined) stressors may fuel the evolution of the stressor interaction pattern, a largely ignored topic in evolutionary ecotoxicology.