A calculation method of tooth root stress for large transmission ratio gear and rack is proposed using a broken-line section model and thermal-mechanical coupling analysis. To describe the transient meshing dynamics between the gear and the rack, a contact deformation model between the gear and the rack is fitted by using the least square method, and the meshing temperature field is calculated using the Blok flash temperature theory. The method of the broken-line section is modified based on the fatigue crack growth path at the tooth root. A new broken-line section model to calculate the tooth root stress is established, and a stress permeability factor is introduced to identify the width of the broken line. Using the meshing temperature field of gear and rack, the calculation formulas of root bending stress and root compression stress are derived by the integral-iterative method under thermal-mechanical coupling, and the correctness of the maximum tooth root stress model is validated by the finite element method (FEM). Compared with other methods for analyzing the thermal strength of gear roots, the proposed novel broken-line section method has simpler calculations and higher accuracy, and it can systematically analyze the effect of structural parameters on the dynamic strength of gear transmission mechanisms under actual working conditions.