As the need for simulations of multi-dimensional behavior in the safety analysis is increasing, efforts have been devoted to developing a three-dimensional module for the conventional system analysis codes. After having developed a one-dimensional system analysis code, MARS, the Korea Atomic Energy Research Institute (KAERI) began to develop the CUPID code to address the need for a multi-dimensional analysis. Recently, the reactor vessel module, such as a package of interfacial heat and momentum transfer model, wall friction and wall-to-fluid heat transfer model, were implemented in the CUPID and named CUPID-RV module. The final goal of this study was an analysis of the Large Break Loss of Coolant Accident (LBLOCA) at a rod-by-rod level, and the study focused on the validation of LBLOCA thermal-hydraulics phenomena and the application to a three-dimensional LBLOCA simulation. In this paper, we introduce the validations using Edward pipe, UPTF, and FLECHT-SEASET experiments related to the LBLOCA blowdown, refill, and reflood phases and a three-dimensional LBLOCA simulation for the APR1400 PWR reactor pressure vessel using simple boundary conditions at an assembly-by-assembly level as an application.