Urban morphology and inter-building shadowing result in a non-uniform distribution of surface heating in urban areas, which can significantly modify the urban flow and thermal field. In Part I, we found that in an idealized three-dimensional urban array, the spatial distribution of the thermal field is correlated with the orientation of surface heating with respect to the wind direction (i.e. leeward or windward heating), while the dispersion field changes more strongly with the vertical temperature gradient in the street canyon. Here, we evaluate these results more closely and translate them into metrics of “city breathability,” with large-eddy simulations coupled with an urban energy-balance model employed for this purpose. First, we quantify breathability by, (i) calculating the pollutant concentration at the pedestrian level (horizontal plane at $$z\approx 1.5$$ –2 m) and averaged over the canopy, and (ii) examining the air exchange rate at the horizontal and vertical ventilating faces of the canyon, such that the in-canopy pollutant advection is distinguished from the vertical removal of pollution. Next, we quantify the change in breathability metrics as a function of previously defined buoyancy parameters, horizontal and vertical Richardson numbers ( $$Ri_\text {h}$$ and $$Ri_\text {v}$$ , respectively), which characterize realistic surface heating. We find that, unlike the analysis of airflow and thermal fields, consideration of the realistic heating distribution is not crucial in the analysis of city breathability, as the pollutant concentration is mainly correlated with the vertical temperature gradient ( $$Ri_\text {v}$$ ) as opposed to the horizontal ( $$Ri_\text {h}$$ ) or bulk ( $$Ri_\text {b}$$ ) thermal forcing. Additionally, we observe that, due to the formation of the primary vortex, the air exchange rate at the roof level (the horizontal ventilating faces of the building canyon) is dominated by the mean flow. Lastly, since $$Ri_\text {h}$$ and $$Ri_\text {v}$$ depend on the meteorological factors (ambient air temperature, wind speed, and wind direction) as well as urban design parameters (such as surface albedo), we propose a methodology for mapping overall outdoor ventilation and city breathability using this characterization method. This methodology helps identify the effects of design on urban microclimate, and ultimately informs urban designers and architects of the impact of their design on air quality, human health, and comfort.