Therapy Research Research Articles

Becoming JEDI Warriors in Physical Therapy Research: A Multifaceted Approach.

By championing cultures that value justice, equity, diversity, and inclusion, individuals within the physical therapy research community have the potential to ignite a powerful transformation in society. The authors envision a future where JEDI warriors emerge, embracing the spirit of "Do or do not. There is no try," to forge a research community that is inclusive for all.1 Drawing inspiration from this mindset, this perspective seeks to empower individuals to harness the force of a JEDI warrior, fostering cultures that value justice, embrace inclusive methodologies, and ensure equitable access to resources and opportunities for researchers and participants.

Exploring the prognostic implications of cuproptosis-associated alterations in clear cell renal cell carcinoma via in vitro experiments

This study investigated the impact of novel copper ionophores on the prognosis of clear cell renal cell carcinoma (ccRCC) and the tumor microenvironment (TME). The differential expression of 10 cuproptosis and 40 TME-pathway-related genes were measured in 531 tumor samples and 71 adjacent kidney samples in The Cancer Genome Atlas database. A risk score model was constructed with LASSO cox to predict the prognosis of ccRCC patients. Forest plot and function enrichment were used to study the biological function of the key genes in depth. The study found that the risk score model accurately predicted the prognosis of ccRCC patients. Patients with high scores had higher immune responses with a higher proportion of anti-tumor lymphocytes and a lower proportion of immunosuppressive M2-like macrophages. However, the high-score group also exhibited a higher proportion of T follicular helper cells and regulatory T cells. These results suggest that cuproptosis-based therapy may be worth further investigation for the treatment of ccRCC and TME. Subsequently, by using RNAi, we established the stable depletion models of FDX1 and PDHB in ccRCC cell lines 786-O and ACHN. Through CCK8, colony formation, and Transwell assays, we observed that the knockdown of FDX1 and PDHB could significantly reduce the capabilities of proliferation and migration in ccRCC cells. In conclusion, this study illuminates the potential effectiveness of copper ionophores in the treatment of ccRCC, with higher risk scores correlating with better TME immune responses. It sets the stage for future cuproptosis-based therapy research in ccRCC and other cancers, focusing on copper’s role in TME.

Development of TaqMan-based real-time PCR based on ψ gene for quantitative detection of CAR-T cells

Chimeric-antigen-receptor-T (CAR-T) have heralded a paradigm shift in the landscape of cancer immunotherapy. Retrovirus-mediated gene transfer serves to deliver the specific CAR expressing cassette into T cells across a spectrum of basic research and clinical contests in cancer therapy. However, it is necessary to devise a precise and validated quantitative methodology tailored to the diverse CAR constructs. In the investigation, a TaqMan real-time qPCR method was developed, utilizing primers targeting ψ gene sequence. This method offers a swift, sensitive, reproducible, and accurate tool for evaluating retroviral copy numbers at the integrated DNA level. Importantly, the established qPCR exhibits no cross-reactivity with non-transduced T cells or tissues. The regression equation characterizing TaqMan real-time PCR dynamics is y = −3.3841x + 41.402 (R2 = 0.999), showing an amplification efficiency of 97.47 %. Notably, the established qPCR method achieves a minimum detection of 43.1 copies/μL. Furthermore, both intra- and inter-group discrepancies remain below 4 %, underscoring the good repeatability of the established method. Our in vitro and in vivo results also support its sensitivity, specificity, and stability. Consequently, this method offers researchers with a cost-effective tool to quantify CAR copies both in vitro and in vivo.

Approaches, Goals, and Scientific Integrity in Music Therapy Research with Individuals on the Autism Spectrum: An Integrative Review.

Scientific integrity is fundamental to evidence-based practice (EBP) and essential in music therapy (MT) research and clinical practice. Researchers conducted an integrative review of approaches and interventions employed by music therapists (MTs) with individuals on the autism spectrum in the context of how studies are analyzed by the National Autism Center (NAC) and National Clearinghouse on Autism Evidence and Practice (NCAEP). Researchers identified 880 database records meeting initial search criteria (i.e., autism spectrum disorder, autism, PDD-NOS, MT, and music interventions); 36 studies remained after screening for duplication, topic relevance, and adherence to inclusion criteria. Included studies were published between 1964 and 2021, in English language, in free open-access journals, worldwide; peer reviewed; conducted by MTs; empirical quantitative, qualitative, or mixed-methods design; intervention-based; and presented separate data for participants on the autism spectrum. Content and quantitative analyses identified deficits in scientific integrity and the following gaps in studies reviewed: Motor Skills and Placement (NAC-defined intervention targets), Computer-based and Songwriting and Composition (MT techniques), and Wellness and Bonny Method of Guided Imagery in Music (clinical approaches); no patterns were evident among NAC Interventions with MT techniques and approaches. Analysis of 5-point Scientific Merit Ratings yielded a mean 2.78 rating. A comparison of NAC and NCAEP terminology (i.e., how MT researchers report independent variables) indicated eight titles mention specific non-music interventions, 19 mention MT, 14 include music-based technique descriptors, and two mention both non-music interventions and MT. Researchers offer guidelines regarding identity-inclusive language, scientific integrity, and clarity of EBPs within MT intervention research with individuals on the autism spectrum.

Trends in dance/movement therapy research: A bibliometric analysis of publications in the scopus bibliographic and citation information database

In recent years, the number of publications on dance/movement therapy has increased. However, there has been no comprehensive quantitative assessment of dance/movement therapy publications that analyze research trends, impact, and structure. This study aims to provide an overview of research trends in dance/movement therapy by identifying the influencing factors of publications and analyzing the research structure. The study analyzed 589 publications retrieved from the Scopus database. Indicators of productivity, impact, and collaboration were determined. The study is the first bibliometric analysis in dance/movement therapy. The results show publications in the fields of medicine, psychology, and healthcare, mainly with authors from the United States, the United Kingdom, Israel, and Germany. Although several publications are available, only a few authors have more than one publication. This resource can be used by researchers, practitioners, and students in dance/movement therapy. It provides an overview of existing research and suggests potential avenues for future research.

Development of an ultrahigh resolution 1 mm Si-PM array based GGAG alpha particle imaging detector with gamma or X-ray separation capability

For precise distribution measurements of alpha particles, as required in alpha radionuclide therapy research, a high-resolution alpha particle imaging detector is desirable. While combining a thin scintillator with a photodetector array, such as a position-sensitive photomultiplier (PSPMT), is a potential method to develop an event-by-event-based alpha particle imaging detector, the spatial resolution is currently limited to around 0.8 mm FWHM. To overcome this limitation, we utilized a small-sized Si-PM array combined with a thin GGAG plate to create an alpha particle imaging detector and evaluated its performance. In the developed alpha particle imaging detector, a Si-PM array with a channel size of 1 mm × 1 mm arranged in an 8 × 8 configuration was optically coupled to a 1 mm thick GGAG plate, with a 1-mm-thick light guide between them. Since the decay times of GGAG differ between alpha particles and gamma photons or X-rays, we were able to separately measure the distributions of alpha particles and gamma photons using pulse shape discrimination. The spatial resolution of the developed alpha particle imaging detector was 0.19 mm FWHM, and the energy resolution was 11% FWHM for 5.5 MeV alpha particles. Additionally, we were able to separately measure the distributions of alpha particles and gamma photons for simultaneously irradiated phantoms using pulse shape discrimination. The developed imaging detector shows promise for distribution measurements of alpha particles, as well as gamma photons or X-rays, where high spatial resolution and separation of gamma photons or X-rays are required.

A critical and interpretive synthesis of arts-based methods used by dance therapy researchers: A perspective from the creative arts therapies

The creative arts therapies are a group of modality specific disciplines that include dance, music, drama and art. Creative arts therapists take an arts-based approach to practice which often results in the privileging of alternate ways of knowing, such as non-verbal, artistic, and embodied forms of expression and meaning-making. The rising interest in arts-based research in our field, as well as within psychology, has prompted us – a dance therapist and music therapist - to take a closer look at the research literature to ascertain the function and purpose of existing arts-based research approaches in the creative arts therapies. Using dance therapy as an example, we conducted a rigorous interpretive review of 12 dance therapy arts-based research articles to help answer the question - ‘what is the function and purpose of arts-based research in dance therapy?‘. As part of our review, we used an arts-based process to synthesise data and to strengthen our analytic process in a manner congruent with artistic ‘ways of knowing.’ Our exploration led us to recognise that arts-based processes appear to enable the ‘illustration’ and ‘illumination’ of novel understanding in ways that are often more difficult to arrive at when using other qualitative research methods. Furthermore, arts-based research can be useful for facilitating researcher reflexivity, which may be used in service of deepening the interpretive process in qualitative research. However, our involvement with the dance therapy publications also revealed a clear shortcoming for the field: at present there appears to be a clear lack of focus on direct client engagement in the arts-based research literature. As such, arts-based research in the field of dance therapy seems to be somewhat removed from professional practice and appears to instead fulfil a more scholarly or self-reflective purpose. Based on this discovery, we offer some recommendations for those interested in pursuing arts-based research within both psychology as well as creative arts therapies, and in doing so highlight the importance of client voice and experience in health-focused research.

Future music therapy programming and research for adults with substance use disorders: A reflexive thematic analysis of service user recommendations

ABSTRACT Introduction Music therapy (MT) can be beneficial regarding craving, motivation, and treatment readiness for adults with substance use conditions (SUC). However, there is a lack of literature investigating service users’ preferences and recommendations regarding MT programming and research. Informed by the recovery movement and evidence-based practice, the purpose of this study was to understand the preferences and recommendations for future MT programming and research of adults with SUC. Method Author 1 provided 24 group recreational MT and songwriting sessions to adults with SUC in a detoxification unit. Author 2 then individually interviewed 46 participants who volunteered to share their perspectives and recommendations regarding future music therapy programming and research. We used an inductive approach to reflexive thematic analysis to analyze data and had a music therapist provide trustworthiness to ensure our findings were credible. Results We organized 12 subthemes into four major themes that described participants’ preferences and recommendations for future MT programming and research for people with SUC: Unit factors; The holistic nature of addiction; MT factors; and Research factors. Findings provided situated context regarding recommendations for MT programming, what to investigate, and how to best conduct the research. Discussion As participants had the lived experience of a SUC and had experienced MT, their recommendations can provide a framework for MT programming and different methods for how to conduct MT research. Implications, limitations, and suggestions for future research are provided.

A systematic review of the nature and efficacy of Rational Emotive Behaviour Therapy interventions.

In the absence of a single comprehensive systematic review of Rational Emotive Behaviour Therapy interventions across all settings, we reviewed the methodological quality, effectiveness and efficacy of Rational Emotive Behaviour Therapy interventions on irrational/rational beliefs. We explored the impact of Rational Emotive Behaviour Therapy on wider outcomes (e.g., mental health) and identified the characteristics of successful interventions. PsycARTICLES, PsycINFO, Scopus, SPORTDiscus, and PubMed were systematically searched up to December 2023 with 162 Rational Emotive Behaviour Therapy intervention studies identified which included a validated measure of irrational/rational beliefs. Where possible, effect size for irrational/rational belief change was reported and data was analysed through a qualitative approach. Using the Mixed Methods Appraisal tool, methodological quality within the Sport and Exercise domain was assessed as good, whilst all other domains were considered low in quality, with insufficient detail provided on intervention characteristics and delivery. Most studies were conducted in the United States, within the Education domain, and assessed irrational beliefs in non-clinical adult samples. Overall, studies reported significant reductions in irrational beliefs, increases in rational beliefs and improvements in mental health outcomes (e.g., depression). More successful interventions were delivered by trained Rational Emotive Behaviour Therapy practitioners, adopted the ABC framework and were longer in duration. We highlight the importance of designing and conducting rigorous future Rational Emotive Behaviour Therapy research to generate clearer insights as to its impact on irrational/rational beliefs and mental health outcomes.

Do we see you? A systematic review of diversity representation in art therapy research conducted between 2010-2020

Art therapy is a mental health profession that enriches the lives of individuals, families, and communities through active art-making, creative process, applied psychological theory, and human experience within a psychotherapeutic relationship. Cultural diversity refers to the differences that exist among groups of people with definable and unique cultural backgrounds. Inclusion puts diversity in practice by respecting and valuing diverse individuals and groups. Diversity representation in art therapy is “seeing” people and ensuring that their viewpoints can be found and represented. Cultural competence in art therapy research is the ability to take culture into account as a central variable that affects every aspect of a study; this fosters the interest, integrity, and dignity of participants and the diverse cultural context of their lives. A systematic review of art therapy research was conducted to provide a critical evaluation of data on diversity representation within existing studies conducted between 2010 – 2020. The ADDRESSING acronym, which evaluates nine aspects of cultural identity, is utilized as a guide for assessment and data collection. The results indicate that diversity representation within the studies was either minimal or non-existent and suggest a need for intentionality about including diversity representation to create a more inclusive art therapy environment.

Global Burden of Lung Cancer: Prognosis, Symptom Management, And Challenges with Pulmonary Fibrosis

Lung cancer represents a significant global health burden, accounting for the highest number of cancer-related deaths worldwide. Despite advancements in treatment modalities, the prognosis remains poor, with a low 5-year survival rate post-diagnosis and substantial mortality within the first year. Patients often experience debilitating symptoms such as fatigue, pain, dyspnea, and coughing, which severely impact their physical and psychological well-being. Pain management is particularly challenging and critical due to its potential leading to depression and anxiety. Lung cancer encompasses histological classifications such as adenocarcinoma, squamous cell carcinoma, large cell carcinoma and small cell lung cancer (SCLC), each with distinctive subtypes. Patients with idiopathic pulmonary fibrosis (IPF) face exacerbated challenges when they also develop lung cancer, impacting their prognosis significantly compared to those with lung cancer alone. The management of pulmonary fibrosis (PF) in lung cancer necessitates a multifaceted approach, incorporating supportive care, pharmacological interventions, and emerging therapies like molecular targeted therapies, gene therapy, and stem cell therapy. This comprehensive management requires collaboration among various healthcare professionals to optimize outcomes and enhance quality of life for affected patients. Despite considerable progress, managing fibrosis in lung cancer remains complex due to its heterogeneous nature and varied progression. Ongoing future research aims to identify biomarkers for early detection, refine treatment strategies, and explore novel therapies through clinical trials. This review highlights lung cancer's global burden, poor prognosis, and severe symptoms impacting patient well-being. It discusses histological types, compounded challenges with IPF, and the need for a multifaceted treatment approach. Emphasis is placed on ongoing research for early detection, refined treatments, and novel therapies to improve outcomes.

AGING MANAGEMENT WITH THE USE OF EXOSOMES, PRP/PRF WITH ALBUMIN GEL (PLASMA GEL) AND ASSOCIATED TECHNIQUES IN OROFACIAL HARMONIZATION TREATMENT

Aging, it is a physiological process that involves a progressive decline in the function of the organs, with loss of homeostasis and increased likelihood of disease disease and death. This account focuses on the classic perspectives on the biogenesis of exosomes, and age-related associated changes. Due to its ability to transmit biological information between cells, this work also discusses the interaction of mesenchymal cell exosomes, as a potent adjuvant in the treatment of association of orofacial harmonization techniques. The demand for aesthetic and rejuvenating treatments is increasing in society, thus, each day, the demand for orofacial harmonization increases exponentially in order to slow aging. Orofacial harmonization is a set of procedures performed by the dentist, which aims at the aesthetic and functional balance of the face. Exosomes are membranous extracellular vesicles ranging from 30 to 200 nm in diameter. Exosomes has been found to be secreted by most cell types, including immune cells (B cells, T cells, mastocytes, dendritic cells), neuronal cells, epithelial cells, endothelial cells, embryonic cells, cancer cells and cells mesenchymal trunk (mscs). The search for youth and perfect skin is a natural desire for the human being. And in this way, collagen biostimulation stands out as a safe and effective option to rejuvenate the skin, fighting the signs of aging and promoting a firmer, toned and radiant appearance. Research in exosomes therapies continues to prosper. Subsequent data on indications, dose response, safety, effectiveness and ability to combine therapy with exosomes as a “skin primer” for biostimulation techniques, such as calcium hydroxylapatite (CAHA), platelet rich plaketers (PRP) and fibrin matrix Platelet plasma, (PRFM) is growing rapidly.

Penerapan Terapi Puzzle Untuk Meningkatkan Fungsi Kognitif Pada Lansia di Panti Werdha Palembang

An elderly person is someone who reaches the age of > 60 years. This increase in age will result in a decrease in the ability of the body's functions, one of which is the nervous system, namely a mild, moderate decline in cognitive function and even dementia. Severe dementia will result in elderly people being unable to carry out activities so that they will experience elderly people who are not prosperous and happy. To overcome this, puzzle therapy is needed. Puzzle therapy is a game of arranging certain shapes until they become a complete image or form a certain pattern. This is to stimulate and improve the cognitive function of the brain. It is known that nursing care for elderly people with decreased cognitive function is provided by providing puzzle therapy. This case study uses a descriptive method with a nursing process approach carried out on 3 clients using a One Group Pretest Posttest puzzle therapy research design on cognitive function in the elderly. The implementation results showed that there was a change in the MMSE score after being given puzzle therapy for 5 consecutive days, namely Mrs. F from 21 to 23, Mrs. L from 22 to 24 while Mrs. E of 16 and still has a score of 16. The average MMSE score which increased after being given puzzle therapy was 2 scores. It is hoped that the results of this case study can become an application for implementing puzzle therapy to improve cognitive function in the elderly where caregivers or nursing home staff can also make puzzle therapy a routine activity that can be carried out every week at the Dharma Bhakti KM 7 Palembang Nursing Home.

Leisure studies and occupational therapy in Latin America: a scoping review

ABSTRACT This study explores the role of leisure in occupational therapy within Latin America, recognising its importance for health, well-being, and participation. Despite its significance, investment in this area is limited in the region. Using various databases and sources like Web of Science, PubMed, and others, alongside theses, dissertations, and books, a scoping review was conducted without time constraints. Employing Joanna Briggs Institute methodology and PRISMA-ScR checklist, 30 eligible references were identified out of 2,276 retrieved. Primarily qualitative and mostly from Brazil, these studies revealed four conceptions of leisure: sociocultural, self-motivated occupation during free time, attitude, and subjectivity with “life production.” The findings indicate a promising but emerging body of research. Emphasis is placed on fostering research agendas through establishing networks and scholarly events dedicated to this theme. It is suggested that occupational therapy researchers create consistent dialogues with leisure studies; commit to the theoretical development of leisure based on the findings of theoretical and empirical research; diversify the analytical scale, including collective and structural processes related to leisure; and invest in creating networks of researchers and scientific events around the theme.

From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer's Disease.

Alzheimer's disease is a progressive neurodegenerative disorder that affects memory and cognitive abilities, affecting millions of people around the world. Current treatments focus on the management of symptoms, as no effective therapy has been approved to modify the underlying disease process. Gene therapy is a promising approach that can offer disease-modifying treatment for AD, targeting various aspects of the pathophysiology of the disease. This review presents a comprehensive overview of the current state of gene therapy research for AD, with a specific focus on clinical trials and preclinical studies that have used nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), apolipoprotein E2 (APOE2), and human telomerase reverse transcriptase (hTERT) as therapeutic gene therapy approaches. These gene targets have shown potential to alleviate the neuropathology of AD in animal studies and have demonstrated feasibility and safety in non-human primates. Despite the failure of the NGF gene therapy approach in clinical trials, we have reviewed and highlighted the reported findings and evaluations from the trials. Furthermore, the review included the conclusions of postmortem brain tissue analysis of AD patients who received NGF gene therapy. The goal is to learn from the failed trials and improve the approach in the future. Although gene therapy shows promise, it faces several challenges and limitations, including optimizing gene delivery methods, enhancing safety and efficacy profiles, and determining long-term results. This review contributes to the growing body of literature on innovative treatments for AD and highlights the need for more research and development to advance gene therapy as a viable treatment option for AD.

Emerging Nanotechnology in Preclinical Pancreatic Cancer Immunotherapy: Driving Towards Clinical Applications.

The high malignant degree and poor prognosis of pancreatic cancer (PC) pose severe challenges to the basic research and clinical translation of next-generation therapies. The rise of immunotherapy has improved the treatment of a variety of solid tumors, while the application in PC is highly restricted by the challenge of immunosuppressive tumor microenvironment. The latest progress of nanotechnology as drug delivery platform and immune adjuvant has improved drug delivery in a variety of disease backgrounds and enhanced tumor therapy based on immunotherapy. Based on the immune loop of PC and the status quo of clinical immunotherapy of tumors, this article discussed and critically analyzed the key transformation difficulties of immunotherapy adaptation to the treatment of PC, and then proposed the rational design strategies of new nanocarriers for drug delivery and immune regulation, especially the design of combined immunotherapy. This review also put forward prospective views on future research directions, so as to provide information for the new means of clinical treatment of PC combined with the next generation of nanotechnology and immunotherapy.

Experiences of Adult Play.

Play has been viewed as a critical occupation supporting health since the founding of occupational therapy, but the complexity of play presents challenges to scholars who study adults. Researchers in occupational science and occupational therapy often address experiential qualities of occupations, including those considered to be play. However, the literature lacks clear descriptions of what constitutes adult play as well as the experiences of adults during preferred activities. To contribute to the body of knowledge on the wide range of preferred activities adults in the United States pursue and may perceive as play experiences. We refer to these activities as adult play because they contain experiential qualities of play described in key play literature. Cross-sectional survey study. A 31-item survey, the Daily Occupational Experience Survey-revised (DOESr), was uploaded to Qualtrics for data collection using snowball sampling. The online survey link was distributed to participants aged 18-64 years. The survey was completed by 491 participants. Exploratory factor analysis was used to extract the most prevalent patterns of play experiences reported. Internal consistency and content validity were also examined. The factor analysis yielded an optimal solution of five factors representing distinct patterns of adult play experiences: Creativity-Adventure, Restoration, Deep Engagement, Ludos, and Mastery. The five factors identified by the DOESr represent distinct patterns of adult play experiences. The DOESr demonstrated acceptable internal consistency for three of the five factors as well as for the overall tool. Plain-Language Summary: Previous research on adult occupations has not addressed the array of experiences that adults seek or enjoy while engaging in play. This study identified five patterns of adult play experiences. Understanding these patterns may assist occupational therapy practitioners when tailoring clients' play experiences to promote optimal health and well-being.

Immune landscape of hepatocellular carcinoma: From dysregulation of the immune responses to the potential immunotherapies.

Hepatocellular carcinoma (HCC) presents a considerable global health burden due to its late diagnosis and high morbidity. The liver's specific anatomical and physiological features expose it to various antigens, requiring precise immune regulation. To the best of our knowledge, this is the first time that a comprehensive overview of the interactions between the immune system and gut microbiota in the development of HCC, as well as the relevant therapeutic approaches are discussed. Dysregulation of immune compartments within the liver microenvironment drives HCC pathogenesis, characterized by elevated regulatory cells such as regulatory T cells (Tregs), myeloid-derived suppressor cells, and M2 macrophages as well as suppressive molecules, alongside reduced number of effector cells like T cells, natural killer cells, and M1 macrophages. Dysbiosis of gut microbiota also contributes to HCC by disrupting intestinal barrier integrity and triggering overactivated immune responses. Immunotherapy approaches, particularly immune checkpoint inhibitors, have exhibited promise in HCC management, yet adoptive cell therapy and cancer vaccination research are in the early steps with relatively less favorable outcomes. Further understanding of immune dysregulation, gut microbiota involvement, and therapeutic combination strategies are essential for advancing precision immunotherapy in HCC.

A bibliometric study related to the treatment of myocardial ischemia-reperfusion Injury

BackgroundMyocardial ischemia-reperfusion injury (MIRI) is defined as the restoration of blood flow to the myocardium after a brief interruption of blood supply, causing more severe damage to the ischemic myocardium. However, currently, reperfusion therapy is the preferred therapy for ischemic cardiomyopathy, which undoubtedly causes MIRI, and thus it has become a challenging issue affecting the prognosis of coronary artery disease.MethodsA search was conducted in the Web of Science Core Collection database for papers relevant to MIRI therapy published between 1 January 2000 and 1 October 2023. Bibliometric analyses were performed using VOSviewer and CiteSpace to elucidate the progress and hotspots.Results3304 papers from 64 countries, 2134 research institutions and 13,228 authors were enrolled in the study. Of these, China contributed the most papers and had the biggest impact, while the United States had the most extensive partnership. The Fourth Military Medical University was the primary research institution. The most valuable authors include Chattipakorn, Nipon, Chattipakorn, Siriporn c, Yang, Jian and Yang, Yang.ConclusionOver the past 20 years, research on MIRI therapies has made significant strides. Further studies are necessary to explore the interactions between various therapeutic options. Future investigations will emphasize nanocarriers, cardiac regeneration, and stem cell therapies. Our study identifies MIRI research hotspots from a bibliometric perspective, forecasts future trends, and offers fresh insights into MIRI therapy research.

Bioactive Materials That Promote the Homing of Endogenous Mesenchymal Stem Cells to Improve Wound Healing.

Endogenous stem cell homing refers to the transport of endogenous mesenchymal stem cells (MSCs) to damaged tissue. The paradigm of using well-designed biomaterials to induce resident stem cells to home in to the injured site while coordinating their behavior and function to promote tissue regeneration is known as endogenous regenerative medicine (ERM). ERM is a promising new avenue in regenerative therapy research, and it involves the mobilizing of endogenous stem cells for homing as the principal means through which to achieve it. Comprehending how mesenchymal stem cells home in and grasp the influencing factors of mesenchymal stem cell homing is essential for the understanding and design of tissue engineering. This review summarizes the process of MSC homing, the factors influencing the homing process, analyses endogenous stem cell homing studies of interest in the field of skin tissue repair, explores the integration of endogenous homing promotion strategies with cellular therapies and details tissue engineering strategies that can be used to modulate endogenous homing of stem cells. In addition to providing more systematic theories and ideas for improved materials for endogenous tissue repair, this review provides new perspectives to explore the complex process of tissue remodeling to enhance the rational design of biomaterial scaffolds and guide tissue regeneration strategies.