Therapy Facility Research Articles

Beam characterisation studies of the 62MeV proton therapy beamline at the Clatterbridge Cancer Centre.

The Clatterbridge Cancer Centre (CCC) in the United Kingdom is the world's first hospital proton beam therapy facility, providing treatment for ocular cancers since 1989. A 62MeV beam of protons is produced by a Scanditronix cyclotron and transported through a passive delivery system. In addition to the long history of clinical use, the facility supports a wide programme of experimental work and as such, an accurate and reliable simulation model of the treatment beamline is highly valuable. However, as the facility has seen several changes to the accelerator and beamline over the years, a comprehensive study of the CCC beam dynamics is needed to firstly examine the beam optics. An extensive analysis was required to overcome facility related constraints to determine fundamental beamline parameters and define an optical lattice written with the Methodical Accelerator Design (MAD-X) and the particle tracking Beam Delivery Simulation (BDSIM) code. An optimised case is presented and simulated results of the optical functions, beam distribution, losses and the transverse rms beam sizes along the beamline are discussed. Corresponding optical and beam information was used in TOPAS to simulate transverse beam profiles and compared to EBT3 film measurements. We provide an overview of the magnetic components, beam transport, cyclotron, beam and treatment related parameters necessary for the development of a present day optical model of the facility. This work represents the first comprehensive study of the CCC facility to date, as a basis to determine input beam parameters to accurately simulate and completely characterise the beamline.

Evaluation of interplay and organ motion effects by means of 4D dose reconstruction and accumulation

PurposePencil beam scanned proton therapy (PBS-PT) treatment quality might be compromised by interplay and motion effects. Via fraction-wise reconstruction of 4D dose distributions and dose accumulation, we assess the clinical relevance of motion related target dose degradation in thoracic cancer patients. Methods and materialsFor the ten thoracic patients (Hodgkin lymphoma and non-small cell lung cancer) treated at our proton therapy facility, daily breathing pattern records, treatment delivery log-files and weekly repeated 4DCTs were collected. Patients exhibited point-max target motion of up to 20 mm. They received robustly optimized treatment plans, delivered with five-times rescanning in fractionated regimen. Treatment delivery records were used to reconstruct 4D dose distributions and the accumulated treatment course dose per patient. Fraction-wise target dose degradations were analyzed and the accumulated treatment course dose, representing an estimation of the delivered dose, was compared with the prescribed dose. ResultsNo clinically relevant loss of target dose homogeneity was found in the fraction-wise reconstructed 4D dose distributions. Overall, in 97% of all reconstructed fraction doses, D98 remained within 5% from the prescription dose. The V95 of accumulated treatment course doses was higher than 99.7% for all ten patients. Conclusions4D dose reconstruction and accumulation enables the clinical estimation of actual exhibited interplay and motion effects. In the patients considered here, the loss of homogeneity caused by interplay and organ motion did not show systematic pattern and smeared out throughout the course of fractionated PBS-PT treatment. Dose degradation due to anatomical changes showed to be more severe and triggered treatment adaptations for five patients.

Comparison of different methods for the shielding analysis of an AB-BNCT facility based on the Be(p,xn) reaction with 30-MeV protons

Five shielding calculation methods were employed to estimate the dose rate distribution around an accelerator-based boron neutron capture therapy facility. Their performances were compared in terms of accuracy and efficiency. The results indicate that the hybrid deterministic/Monte Carlo method is the most efficient in the context of accurate modeling and simulation, whereas the analytical approximation with pre-generated source terms and attenuation lengths is preferable in the design phase because of its simplicity and ease of verification while retaining a reasonable accuracy.

Neutron yields of Be-9(p,xn) reactions and beam characterization for accelerator-based boron neutron capture therapy facility using MCNP6, PHITS, and GEANT4 simulation results

Neutron yields from 9Be(p,xn) reactions with a 2-cm thick beryllium target bombarded by proton beams of 5, 6, 7, 8, 9, and 10 MeV were investigated. Neutron beam characteristics through a pilot design of beam shaping assembly were calculated by using MCNP6, PHITS, and GEANT4. The neutron yield with a 10 MeV beam by MCNP6 was 7.7 times larger than values by the other codes, but close to the experimental data. The neutron spectrum and directionality were different among the codes. These differences could stem from different cross-section libraries and models used in the codes. The epithermal flux at the beam irradiation port by MCNP6 was 1.4 × 109 cm−2 s−1 for a proton current of 8 mA hitting the target. The ratio of thermal and epithermal flux was less than 0.01 and the forward directionality was 0.78. However, we suggest a new criterion regarding a ratio of fast and epithermal flux.

Geometry optimisation of graphite energy degrader for proton therapy

Introduction: Cyclotron-based proton therapy facilities use an energy degrader of variable thickness to deliver beams of the different energies required by a patient treatment plan; scattering and straggling in the degrader give rise to an inherent emittance increase and subsequent particle loss in the downstream energy-selection system (ESS). Here we study alternative graphite degrader geometries and examine with Monte-Carlo simulations the induced emittance growth and consequent particle transmission.Methods: We examined the conventional multiple-wedge degrader used in the Paul Scherrer Institute PROSCAN proton therapy system, the equivalent parallel-sided degrader, and a single block degrader of equivalent thickness. G4Beamline Monte-Carlo tracking of protons was benchmarked against measurements of the existing degrader for proton energies from 75 to 230 MeV, and used to validate simulations of the alternative geometries.Results: Using a careful calculation of the beam emittance growth, we determined that a single-block degrader placed close to the collimators of the ESS is expected to deliver significantly larger transmission, up to 17% larger at 150 MeV. At the lowest deliverable of 75 MeV there is still a clear improvement in beam transmission.Conclusions: Whilst dose rates are not presently limited on the PROSCAN system at higher energies, a single-block degrader offers the ability to access either lower energies for treatment or a larger dose rate at 75 MeV in case transmission optimisation is desired. Single-block degraders should be considered for the delivery of low-energy protons from a cyclotron-based particle therapy system.

Monte Carlo simulations and dose measurements of 2D range-modulators for scanned particle therapy

This paper introduces the concept of a 2D range-modulator as a static device for generating spread-out Bragg peaks at very small distances to the target. The 2D range-modulator has some distinct advantages that can be highly useful for different research projects in particle therapy facilities. Most importantly, it creates an instantaneous, quasi-static irradiation field with only one energy, thus decreasing irradiation time tremendously. In addition, it can be manufactured fast and cost efficiently and its SOBP width and shape can be adjusted easily for the specific purpose/experiment. As the modulator is a static element, there is no need for rotation (e.g. like in a modulation wheel) or lateral oscillation and due to the small base structure period it can be positioned close to the target.Two different rapid prototyping manufacturing techniques were utilized. The modulation properties of one polymer and one steel modulator were investigated with both simulations and measurements. For this purpose, a sophisticated water phantom system (WERNER), that can perform fast, completely automated and high resolution dose measurements, was developed. Using WERNER, the dose distribution of a modulator can be verified quickly and reliably, both during experiments, as well as in a time constrained clinical environment.The maximum deviation between the Monte Carlo simulations and dose measurements in the spread-out Bragg peak region was 1.4% and 4% for the polymer and steel modulator respectively. They were able to create spread-out Bragg peaks with a high degree of dose homogeneity, thus validating the whole process chain, from the mathematical optimization and modulator development, to manufacturing, MC simulations and dose measurements.Combining the convenience, flexibility and cost-effectiveness of rapid prototyping with the advantages of highly customizable modulators, that can be adapted for different experiments, the 2D range-modulator is considered a very useful tool for a variety of research objectives. Moreover, we have successfully shown that the manufacturing of 2D modulators with high quality and high degree of homogeneity is possible, paving the way for the further development of the more complex 3D range-modulators, which are considered a viable option for the very fast treatment of moving targets and/or FLASH irradiation.

Dosimetry of laser-accelerated carbon ions for cell irradiation at ultra-high dose rate

Charged particle radiotherapy is currently used in an increasing number of centres worldwide. While protons are the most widely used ion species, carbon ions have shown many advantages for the treatment of radioresistant tumours, thanks to their higher Linear Energy Transfer (LET) and Relative Biological Effectiveness (RBE). The complexity and the high cost of conventional carbon therapy facilities has stimulated the investigation of alternative acceleration approaches such as the processes based on high-power laser interaction with solid targets. Recent developments in ion acceleration have allowed to investigate for the first time the biological effects of carbon ions at ultra-high dose-rate (109-1010 Gy/s) using the GEMINI laser system at Rutherford Appleton Laboratory (RAL). Carbon ions were accelerated from ultrathin (10-20 nm) carbon foils and energy selected by a magnet allowing to irradiate the cells with an average carbon energy of 10 MeV/u ± 8%. A dosimetry approach specifically designed for these low-energy ions was employed, which was based on the use of unlaminated EBT3 Radiochromic films. The details of the dosimetry arrangement as well as the Geant4 simulation performed to predict the energy and the dose distribution at the cell plane will be reported.

Design and Optimization Based on Monte Carlo Method of a Range Shifter for Proton Therapy

A proton therapy facility based on an isochronous superconducting cyclotron is under constructed at the Proton Therapy Facility of the Huazhong University of Science and Technology. Due to the limitation of minimum energy extracted by the energy selection system in the upstream beamline, a range shifter is installed at the end of the nozzle to further decrease the proton beam energy so that the shallow-seated tumors can be treated. In this paper, the physical structure, energy degradation scheme, and material optimization selection of the range shifter are discussed and analyzed by Monte Carlo simulation software Geant4 and FLUKA. At the same time, the treatment outcome on the energy degradation process and its influence on the synthesis of spread-out Bragg peak (SOBP) in the treatment plan system after the application of the range shifter are analyzed. The results show that by using a high-density polyethylene energy-degrading plate with a thickness of 42.35 mm, combined with two 30-mm copper collimators, the range shifter can achieve a good energy-degradation effect while significantly reducing the beam horizontal penumbra at the edge of the radiation field. At the same time, the addition of the range shifter can reduce the number of the energy level required to form the SOBP and shorten the treatment time, but it will inevitably lead to a slight increase in the longitudinal penumbra.

Psychosocial Support for Pediatric Patients at Proton Therapy Institutions.

PurposePediatric patients with cancer benefit significantly from psychosocial support during and after treatment, but to date, limited data exist regarding the patterns of psychosocial support provided to patients in radiation oncology departments. The purpose of this study was to assess the supportive care services provided at proton therapy institutions in the United States with a specific focus on education, parental involvement, and coping techniques.Materials and MethodsPhysicians, nurses, and child life specialists at 29 operational proton therapy facilities in the United States were sent an online questionnaire regarding pediatric treatment support. The survey consisted of 10 questions exploring strategies employed to educate and support pediatric patients before and during radiotherapy.ResultsStaff members from 23 of 29 operational proton centers (79%) in the United States completed the survey. Three centers (10%) declined to participate, and three (10%) did not complete the questionnaire. Respondents permitted parental presence for body positioning on the first day of treatment and every day of treatment if needed at 95.6% (22 of 23) and 73.9% (17 of 23) of the centers, respectively. Primary education methods included a facility tour (91.3%; 21 of 23) and psychological preparation (78.3%; 17 of 23). Physicians (82.6%; 19 of 23), nurses (73.9%; 17 of 23), and child life specialists (69.6%; 16 of 23) most commonly provided education to pediatric patients and their families. Only 21.7% (5 of 23) of the facilities reported documentation of a psychosocial support policy. Common coping techniques included music (87.0%; 20 of 23), parental presence for positioning (73.9%; 17 of 23), listening to audio recordings (73.9%; 17 of 23), aromatherapy on or near the patient (73.9%; 17 of 23), and use of a stress ball (65.2%; 15 of 23).ConclusionProton therapy institutions frequently offered psychologic preparation before treatment and employed various coping strategies. Based on this survey, we propose several recommendations to raise awareness and improve the experience of pediatric patients at radiation oncology centers.

Developing a Monte Carlo model for MEVION S250i with HYPERSCAN and Adaptive Aperture™ pencil beam scanning proton therapy system

AbstractAim:As the number of proton therapy facilities has steadily increased, the need for the tool to provide precise dose simulation for complicated clinical and research scenarios also increase. In this study, the treatment head of Mevion HYPERSCAN pencil beam scanning (PBS) proton therapy system including energy modulation system (EMS) and Adaptive Aperture™ (AA) was modelled using TOPAS (TOolkit for PArticle Simulation) Monte Carlo (MC) code and was validated during commissioning process.Materials and methods:The proton beam characteristics including integral depth doses (IDDs) of pristine Bragg peak and in-air beam spot sizes were simulated and compared with measured beam data. The lateral profiles, with and without AA, were also verified against calculation from treatment planning system (TPS).Results:All beam characteristics for IDDs and in-air spot size agreed well within 1 mm and 10% separately. The full width at half maximum and penumbra of lateral dose profile also agree well within 2 mm.Finding:The TOPAS MC simulation of the MEVION HYPERSCAN PBS proton therapy system has been modelled and validated; it could be a viable tool for research and verification of the proton treatment in the future.

Optimization of hexagonal-pattern minibeams for spatially fractionated radiotherapy using proton beam scanning.

In this study, we investigated computationally and experimentally a hexagonal-pattern array of spatially fractionated proton minibeams produced by proton pencil beam scanning (PBS) technique. Spatial fractionation of dose delivery with millimeter or submillimeter beam size has proven to be a promising approach to significantly increase the normal tissue tolerance. Our goals are to obtain an optimized minibeam design and to show that it is feasible to implement the optimized minibeams at the existing proton clinics. An optimized minibeam arrangement is one that would produce high peak-to-valley dose ratios (PVDRs) in normal tissues and a PVDR approaching unity at the Bragg peak. Using Monte Carlo (MC) code TOPAS we simulated proton pencil beams that mimic those available at the existing proton therapy facilities and obtained a hexagonal-pattern array of minibeams by collimating the proton pencil beams through the 1-3mm diameter pinholes of a collimator. We optimized the minibeam design by considering different combinations of parameters including collimator material and thickness (t), center-to-center (c-t-c) distance, and beam size. The optimized minibeam design was then evaluated for normal tissue sparing against the uniform pencil beam scanning (PBS) by calculating the therapeutic advantage (TA) in terms of cell survival fraction. Verification measurements using radiochromic films were performed at the Emory proton therapy center (EPTC). Optimized hexagonal-pattern minibeams having PVDRs of >10 at phantom surface and of >3 at depths up to 6cm were achieved with 2mm diameter modulated proton minibeams (with proton energies between 120 and 140MeV) corresponding to a spread-out-Bragg-peak (SOBP) over the depth of 10-14cm. The results of the film measurements agree with the MC results within 10%. The TA of the 2mm minibeams against the uniform PBS is >3 from phantom surface to the depth of 5cm and then smoothly drops to ~1.5 as it approaches the proximal edge of the SOBP. For 2mm minibeams and 6mm c-t-c distance, we delivered 1.72Gy at SOBP for 7.2×7.2×4cm3 volume in 48s. We conclude that it is feasible to implement the optimized hexagonal-pattern 2mm proton minibeam radiotherapy at the existing proton clinics, because desirable PVDRs and TAs are achievable and the treatment time is reasonable.

Central Review of Radiation Therapy Planning Among Patients with Breast-Conserving Surgery: Results from a Quality Assurance Process Integrated into the INSEMA Trial

After publication of the radiation field design in the American College of Surgeons Oncology Group Z0011 trial, a radiation therapy quality assurance review was integrated into the Intergroup-Sentinel-Mamma (INSEMA) trial. We aimed to investigate the role of patient characteristics, extent of axillary surgery, and radiation techniques for dose distribution in ipsilateral axillary levels. INSEMA (NCT02466737) has randomized 5542 patients who underwent breast-conserving surgery. Of these, 276 patients from 108 radiation therapy facilities were included in the central review, using the planning records of the first 3 patients treated at each site. Of the 276 patients, 41 had major deviations (ie, no axillary contouring or submission of insufficient records) leading to exclusion. A total of 235 (85.1%) radiation therapy planning records were delineated according to the INSEMA protocol, including 9 (3.8%) cases with minor deviations. At least 25% of INSEMA patients were unintentionally treated with ≥95% of the prescribed breast radiation dose in axillary level I. Approximately 50% of patients were irradiated with a median radiation dose of more than 85% of prescription dose in level I. Irradiated volumes and applied doses were significantly lower in levels II and III compared with level I. However, 25% of patients still received a median radiation dose of ≥75% of prescription dose to level II. Subgroup analysis revealed a significant association between incidental radiation dose in the axilla and obesity. Younger age, boost application, and fractionation schedule showed no impact on axillary dose distribution. Assuming ≥80% of prescribed breast dose as the optimal dose for curative radiation of low-volume disease in axillary lymph nodes, at least 50% of reviewed INSEMA patients received an adequate dose in level I, even with contemporary 3-dimensional techniques. Dose coverage was much less in axillary levels II and III, and far below therapeutically relevant doses.

Development and measurement of a fast kicker magnet applied to a proton therapy facility

A proton therapy facility based on spot scanning technique requires a fast ON/OFF beam switch during beam spots and energy modulation procedures. At HUST, a proton therapy facility (HUST-PTF) with multiple treatment rooms is under development. For HUST-PTF, this beam switch function is implemented by a fast kicker magnet and downstream beam dump. This paper introduces the development and measurement of this kicker magnet system, with main topics: (1) the development and measurement of the fast kicker magnet; (2) the corresponding pulsed power supply to implement the kicker function; (3) the dynamic magnetic field measurement system based on printed circuit board (PCB) technique.

Maintaining excellence in a high volume academic cell therapy production facility through optimization of space utilization, operations, scheduling and staffing

Background & Aim The Clinical Cell and Vaccine Production Facility (CVPF) at UPenn is a FACT accredited resource with a 25 year record of novel first-in-human cell and gene therapy clinical trials. CVPF is integrated with research, process development, and correlative studies laboratories, QC/QA, clinical operations and monitoring, apheresis facilities and infusion sites. CVPF has two clean room facilities in which cell immunotherapy products are currently manufactured in support of >15 investigational new drug (IND) protocols. Methods, Results & Conclusion CVPF recently developed a clean room space utilization model to increase production capacity. Previously, a product occupied a single processing suite for the length of manufacture. Improvements to the processing room layout and implementation of a “bioreactor nursery” allowed for expansion of multiple products in a single space. Other benefits included fewer equipment pieces required and built-in redundancy. Additionally, we developed a standardized production slot model to reduce the rate of unfilled manufacturing slots and maximize facility efficiency. A standardized schedule along with the application of scheduling software has improved resource management, effort tracking, production task scheduling and capacity projections. Standardized scheduling is more efficient in scheduling manufacturing staff, sample transport, environmental monitoring, facility cleaning, equipment maintenance, QC testing, batch record preparation and review and product release. We developed an accelerated training program that reduced time-to-proficiency (TTP) for new hires through resource assignment, dedicated training space and re-designed curricula. A mock processing suite was established outside of the clean room space to allow for non-GMP materials to be used during training, greatly reducing cost. Still, staff recruitment, retention and training continue to be a challenge for academic manufacturing facilities as staff renewal limits production capacity and results in fewer patients enrolled in clinical trials. CVPF joined forces with University leadership to develop a novel metrics based career advancement track for cell therapy technologists. These techniques for increased productivity coupled with improved training methods and staff retention initiatives can be adopted by academic cell therapy facilities to optimize staffing, reduce costs and increase efficiencies, thereby increasing production capacity and patient clinical trial enrollment.

Analysis by Monte Carlo methods of the response of an extended-range Bonner Sphere Spectrometer

High-energy neutrons up to 230 MeV are generated as a consequence of (p,n) nuclear reactions in proton therapy facilities. The aim of this work is to evaluate the potential extension of the UPM Bonner Sphere Spectrometer (BSS) through the use of spallation materials, for its future application to determine neutron fluence spectra in such facilities. Monte Carlo methods have been used to model the response of the actual and modified spheres with the introduction of a spallation material layer, lead or copper, analyzing their response functions. An analysis is also made of the neutron fluence spectra over the 6LiI(Eu) scintillator volume and the uncertainty that can be associated to the response functions at high energies as a consequence of the different physics models that can be applied for their analysis.

Bubble Formation in the Electrolyte Triggers Voltage Instability in CO2 Electrolyzers.

SummaryThe electrochemical reduction of CO2 is promising for mitigating anthropogenic greenhouse gas emissions; however, voltage instabilities currently inhibit reaching high current densities that are prerequisite for commercialization. Here, for the first time, we elucidate that product gaseous bubble accumulation on the electrode/electrolyte interface is the direct cause of the voltage instability in CO2 electrolyzers. Although bubble formation in water electrolyzers has been extensively studied, we identified that voltage instability caused by bubble formation is unique to CO2 electrolyzers. The appearance of syngas bubbles within the electrolyte at the gas diffusion electrode (GDE)-electrolyte chamber interface (i.e. ∼10% bubble coverage of the GDE surface) was accompanied by voltage oscillations of 60 mV. The presence of syngas in the electrolyte chamber physically inhibited two-phase reaction interfaces, thereby resulting in unstable cell performance. The strategic incorporation of our insights on bubble growth behavior and voltage instability is vital for designing commercially relevant CO2 electrolyzers.

Practice Considerations for Proton Beam Radiation Therapy of Uveal Melanoma During the Coronavirus Disease Pandemic: Particle Therapy Co-Operative Group Ocular Experience

Uveal melanoma (UM) is a rare but life-threatening cancer of the eye. In light of the coronavirus disease (COVID-19) pandemic, hospitals and proton eye therapy facilities must analyze several factors to ensure appropriate treatment protocols for patients and provider teams. Practice considerations to limit COVID-19 transmission in the proton ocular treatment setting for UM are necessary. The Particle Therapy Co-Operative Group is the largest international community of particle/proton therapy providers. Participating experts have current or former affiliation with the member institutions of the Particle Therapy Co-Operative Group Ocular subcommittee with long-standing high-volume proton ocular programs. The practices reviewed in this document must be taken in conjunction with local hospital procedures, multidisciplinary recommendations, and regional/national guidelines, as each community may have its unique needs, supplies, and protocols. Importantly, as the pandemic evolves, so will the strategies and recommendations. Given the unique circumstances for UM patients, along with indications of potential ophthalmologic transmission as a result of health care providers working in close proximity to patients and intrinsic infectious risk from eyelashes, tears, and hair, practice strategies may be adapted to reduce the risk of viral transmission. Certainly, providers and health care systems will continue to examine and provide as safe and effective care as possible for patients in the current environment.

Structural Optimization of Fast Scanning Magnets for Proton Therapy Device

A new proton therapy facility is under construction in Huazhong University of Science and Technology. Scanning magnets play an important role in this device. They can form an arbitrary two-dimensional radiation shape conformal with the tumor. In the pencil beam scanning system, the magnetic fields are excited by time-varying currents and the maximum repetition is up to 50 Hz. Therefore, the temperature rises of two magnets caused by eddy currents should be considered. In this paper, the coupling analysis of Multiphysics was carried out by COMSOL electromagnetic thermal module to optimize the magnetic pole structure of the scanning magnet. The tapered air gap of the downstream magnet X was designed to match the deflection envelope of the proton beam after the upstream magnet Y. The pole of the magnet SMX was optimized to meet the requirement of the local and integral fields. The module of natural convection and surface heat radiation were used to replace the empirical heat transfer coefficient in the thermal analysis so that the simulation agrees better with reality. The results show that the accuracy of the heat transfer coefficient should be further validated by comparison with the simulation that is more realistic.

Patient satisfaction with the CMC controller: A cohort study

Study DesignCohort study. IntroductionThe evidence specific to understanding patient satisfaction, preference and the effects on occupational performance using a CMC orthosis is sparse. Purpose of the StudyThe main purpose of this study was to determine patient satisfaction, aspects of the orthotic preference, and the effect on pain and function of the CMC Controller Plus neoprene orthotic device. MethodsThis research was conducted at two outpatient clinics located in Pennsylvania and Florida during 2019. The subjects of this study included any individuals referred to one of two participating hand therapy facilities with either a primary or secondary diagnosis of thumb CMC joint arthritis or present with this diagnosis as a comorbidity. The CMC Controller Plus orthosis (Hely & Weber) was provided to each patient by the treating therapist at no cost to the patient after the patient agreed to take part in the study. None of the patients received hand therapy treatment for the CMC pain; the only intervention provided was the CMC Controller Plus. ResultsThe CMC Controller Plus orthosis improved the patients' functional status and reduced their pain. The effect size for the change in function was large (1.29) compared to the effect size for the reduction in pain which approached moderate at 0.49. DiscussionThe CMC Controller Plus orthosis improved the patient's functional status by 52% and reduced their pain by 29%. ConclusionThe results were both statistically and clinically significant.

Design and Test of the Power Supply for a Fast Kicker Magnet

To perform fast beam switch during spot scanning and energy modulation procedure, a fast kicker magnet system is adopted in HUST-PTF (Huazhong University of Science and Technology Proton Therapy Facility). The rising/falling time is expected to be less than 100 μs, and the maximum repetition rate should be up to 500 Hz. To meet the specifications on dynamic response of the power supply, a solution with two separate DC link scheme is present in this paper. Since the Kicker is closed to other sensitive equipment, an output filter is installed to prevent electromagnetic disturbances from propagating along the cables. The optimized design of the output filter and comparison measurement results of the power supply are introduced as well. Here, a trade-off between the voltage oscillation, dynamic performance and engineering implementation has been made.