BACKGROUND: Leukemia patients often face significant psychological stress due to the uncertainty of their disease’s outcome, the side effects of treatment, and the profound changes to their lives. Effective stress management interventions are crucial for improving their quality of life and psychological well-being. OBJECTIVE: This article aims to explore and evaluate the theoretical frameworks and practical interventions for managing stress perception in leukemia patients, providing an integrated view of the current methodologies and their outcomes. METHODS: We review and synthesize the literature on stress perception interventions within leukemia care, focusing on mindfulness theory, cognitive behavioral theory, and the theory of uncertainty in illness. We assess the efficacy of various interventions, including mindfulness-based stress reduction, cognitive behavioral therapy, stress inoculation training, and graded interventions, alongside the utilization of measurement tools such as the Perceived Stress Scale (PSS) and the Perceived Stress Questionnaire (PSQ). RESULTS: The reviewed interventions demonstrate significant potential in reducing stress perception among leukemia patients. Mindfulness-based approaches help patients focus on the present and reduce rumination, cognitive behavioral interventions address negative thought patterns contributing to stress, and graded interventions tailor care to individual patient needs. Furthermore, the application of stress measurement tools provides a quantitative basis for evaluating intervention efficacy. CONCLUSION: Integrative stress management interventions, grounded in comprehensive theoretical frameworks, offer significant benefits for leukemia patients, contributing to lower stress levels and improved overall well-being. Healthcare providers are encouraged to incorporate these interventions into standard leukemia care, ensuring a holistic approach to patient treatment. Future research should aim to innovate and refine these interventions, ensuring they are accessible, feasible, and effective for the diverse leukemia patient population.