The paper discusses the analytical stability and numerical stability of differential equations with piecewise constant arguments with matrix coefficients. Firstly, the Runge-Kutta method is applied to the equation and the recurrence relationship of the numerical solution of the equation is obtained. Secondly, it is proved that the Runge-Kutta method can preserve the convergence order. Thirdly, the stability conditions of the numerical solution under different matrix coefficients are given by Pad$\acute{e}$ approximation and order star theory. Finally, the conclusions are verified by several numerical experiments.
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