This article explores the formation and development of transregional relations of territorial communities of France with Eastern countries and regions. It examines the interplay of centrifugal and centripetal tendencies in the “center-regions” relationship of the French Republic. The analysis focuses on the normative framework of international and foreign policy activities of French territorial communities based on national constitution and legislation. Traditional close ties of French regions with partners from European countries are discussed, with a special emphasis on collaborations with countries in Eastern and Southern Mediterranean, as well as North Africa. Partnership with distant Eastern territories is separately examined. The study is based on a comprehensive methodology incorporating principles of historicism, objectivity, comprehensiveness, historical-systemic and historical-comparative approaches, as well as theoretical foundations of multilevel governance theory. It includes an examination of the activities of various administrative units in France: regions, departments, municipalities, cities, and metropolises. The conclusion drawn is that the international activities of French regions are currently less active than those of regions in other European Union countries; however, in the 21st century, they have significantly intensified compared to previous periods.