On the theoretical side, the author gives a detailed critical review of the views that interpret the essence of Graves' disease. So, he considers and consistently rejects, in view of significant shortcomings, theories; hematogenous, assuming the essence of suffering in "abnormal mixing of blood by analogy with chloranemic mixing" - neurogenic, sympathetic and bulbar, as leading to obvious contradictions or not giving undoubted results - and the theory of neuroses, as "not containing the whole truth" and leaving unknown pathogenic agent that acted on the nervous system in this direction.