We have carried out an analysis of longterm results of using aldosterone antagonists (spironolactone and eplerenone) in a holiatry of patients with myocardial infacrtion and heart failure. The functional condition of the myocardium has been investigated by means of electrocardiography, the level of the neurohumoral messengers – aldosterone, angiotensin-converting enzym, atrial natriuretic peptide, Willebrand`s factor has been determined. It has been demonstrated that with the use of eplerenone there exists a higher probability of restoring the functional state of the myocardium in patients – an increase of the ejection fraction by 16,1 %, the stroke volume by 23,2 %. According to the theory of chances it has been established that, while using eplerenone, the likelihood of achieving the mass of the myocardium of the left ventricle less than 180,24±15,24 g is sighnificantly higher than the use of spironolactone (t=2,10, р<0,05). While analyzing the concentration of the blood plasma aldosterone it was establishes that in a year its content essentially decreased in both groups, although it was more marked in persons who took eplerenone (р<0,01).