Basic Research Research Articles

Features of distribution of electric field strength and current density in the reactor during treatment of liquid media with high-voltage pulse discharges

Purpose. Development and use of a mathematical model of the stages of formation of high-voltage pulse discharges in gas bubbles in the discharge gap «rod-plane» to identify the features of the electric field intensity distribution in the reactor and determine the current density in the load during disinfection and purification of liquid media by high-voltage pulse discharges and find the most rational treatment. Methodology. To achieve this goal, we used computer modeling using the finite element method as a method of numerical analysis. An experimental reactor model was created that takes into account the dynamics of discharges in gas bubbles in water. The equations describing the system include the generalized Ampere equation, the Poisson equation and the electric displacement equation, taking into account the corresponding initial and boundary conditions, as well as the properties of materials. The dependence of the potential of a high-voltage electrode on time has the form of a damped sinusoid, and the specific electrical conductivity in a gas bubble is a function of time. Processes occurring at the front of the voltage pulse from 0 to 20 ns are considered. Results. It is shown that with an increase in conductivity and high-voltage potential to amplitude values in a gas bubble, the electric field strength in the water layer in the reactor reaches 70 kV/cm, and it is in the water layer that there is a strong electric field. The calculations show that already by 19th ns the density of conduction currents in water prevails over that of displacement currents. At the same time, additional inclusions in the water significantly affect the distribution of electric field strength and current density, creating a significant difference in their values at the boundaries of the interface between the bubble, conductive element and water. Originality. A simulation of the dynamics of transient discharge processes in a gas bubble and a layer of water with impurities was carried out, including an analysis of the distribution of the electric field strength and current density in a system with rod-plane electrodes in the phase transition section of a gas bubble-water. This approach allows us to reveal the features of processes in reactors and to investigate the influence of phase transitions on the distribution of electrophysical quantities. Practical value. Computer simulations confirm the prospect of using nanosecond discharges generated in gas bubbles within a volume of water for widespread industrial use and are of great interest for further experimental and theoretical research. References 25, figures 9.

Phylogeny and bioprospecting: The diversity of medicinal plants used in cancer management

Societal Impact StatementAs the second‐leading cause of mortality worldwide, cancer is a major focus of drug discovery research. Traditional plant knowledge can guide the search for undiscovered compounds, but the efficacy of this approach for cancer, a highly complex disease affecting diverse tissues, is unknown. We investigated the patterns underlying plant selection for cancer treatment globally, finding certain lineages are repeatedly targeted. While this indicates therapeutic value, their relatedness with plants used for unrelated ethnobotanical uses suggests that plants are probably selected to treat cancer‐associated symptoms, rather than addressing tumour growth. Careful re‐examination and scoring of ethnobotanical reports may make the prediction of lineages for drug discovery more informative.Summary Cancer is a highly diverse disease and as the second‐leading cause of death worldwide is a focus of drug discovery research. Natural products have been shown to be a useful source of novel molecules for treating cancer. It is likely there are many plants with undiscovered molecules of therapeutic value, however identifying new leads from the vast diversity of plants is very challenging. Traditional knowledge might inform bioprospecting by predicting lineages of plants rich in therapeutically useful molecules. We characterise the phylogenetic diversity of plants used in traditional cancer management using a comprehensive genus‐level phylogeny of angiosperms, and a list of 597 genera used globally to treat different cancers. We phylogenetically predict which lineages may have elevated potential for drug discovery and assess the quality of the prediction. We demonstrate the independent and repeated targeting of specific lineages of plants by different peoples in different parts of the world. However, the lineages we report here as rich in plants used in traditional cancer management coincide with those for other ethnobotanical applications and contain few plants with proven anti‐cancer activity. That the same lineages are used to treat different cancers is suggestive of independent discovery of therapeutic value. However, it is likely that the traditional knowledge explored here is shaped by the selection of plants conferring milder effects for treating wider symptoms, such as tiredness or nausea, rather than for halting tumour growth. Accurate prediction of useful plant lineages for cancer management requires more nuanced information than is commonly provided in ethnobotanical records.

Deep-blue electroluminescence with orthogonal donor-acceptor structure: The role of charge-transfer excited state component in hybrid local and charge-transfer (HLCT) excited state

In this work, three orthogonally bonded phenanthroimidazole based donor-acceptor (D-A) structured blue-emissive materials N-SBPMCN, N-ABPMCN and N-TBPMCN with different donor moieties are designed synthesized. Theoretical combined experimental researches proved that the involving of weak donor (spiro-fluorene and anthracene) and strong donor triphenylamine can form different locally-emissive (LE) dominated hybrid local and charge-transfer (HLCT) excited state, which can contribute to their high photoluminescent quantum yield (PLQY), satisfied electroluminescence performance and blue purity. Specifically, N-TBPMCN with strong donor triphenylamine that possesses more CT excited state components demonstrates the best electroluminescence performance and blue purity among the three materials, revealing that the molecular design of orthogonal D-A structure is of great potential in blue-emissive functional materials. Additionally, we also discovered that intermolecular CT state can also contribute to high exciton utilization.

Spatial transcriptomic revealed intratumor heterogeneity and cancer stem cell enrichment in colorectal cancer metastasis

Metastasis is the main cause of mortality in colorectal cancer (CRC) patients. Exploring the mechanisms of metastasis is of great importance in both clinical and fundamental CRC research. CRC is a highly heterogeneous disease with variable therapeutic outcomes of treatment. In this study, we applied spatial transcriptomics (ST) to generate a tissue-wide transcriptome from two primary colorectal cancer tissues and their matched liver metastatic tissues. Spatial RNA information showed intratumoral heterogeneity (ITH) of both primary and metastatic tissues. The comparison of gene expressions across tissues revealed an apparent enrichment of cancer stem cells (CSCs) in metastatic tissues and identified FOXD1 as a novel metastatic CSC marker. Trajectory and pseudo-time analyses revealed distinct evolutionary trajectories and a dedifferentiation-differentiation process during metastasis. CellphoneDB analysis suggested a dominant interaction of CD74-MIF with tumor cells in metastatic tissues. Further analysis confirmed FOXD1 as a maker of CSCs and the predictor of patient survival, especially in metastatic diseases. Our study found ITH of primary and metastatic tissues and provides novel insights into the cellular mechanisms underlying liver metastasis of CRC and foundations for therapeutic strategies for CRC metastasis.

Configuration synthesis and screening method for multiple closed-loop unit tandem mechanisms

To broaden the methods of configuration synthesis, this study proposes a new method for configuration synthesis and screening of multiple closed-loop unit tandem mechanisms. Firstly, some closed-loop configurations are taken as basic units, and the closed-loop basic units are synthesized in series under the condition of considering the basic unit types, contacts, and input and output relationships. Secondly, the connectivity of the mechanism is obtained by weighting the adjacency matrix, and the entropy weight method is used for the first time to establish a comprehensive evaluation index coefficient to assess the quality of the mechanism. Then, an improved simulated annealing-greedy algorithm is proposed and an algorithm software screening platform is built to screen mechanisms. Finally, the multi-fingered grasper is used as design case to verify the practicality of the proposed configuration synthesis and screening method. This study can provide a reference for theoretical research on the configuration synthesis and screening methods of multiple closed-loop unit tandem mechanisms.

Stress Suppression Design for Radiofrequency Microelectromechanical System Switch Based on a Flexible Substrate.

A novel stress suppression design for flexible RF MEMS switches has been presented and demonstrated through theoretical and experimental research to isolate the stress caused by substrate bending. An RF MEMS switch with an S-shaped microspring structure was fabricated by the two-step etching process as a developmental step toward miniaturization and high reliability. The RF MEMS switches with an S-shaped microspring exhibited superior microwave performance and stable driving voltage under different substrate curvatures compared to the conventional non-microspring switches, demonstrating that the bending stress is successfully suppressed by the S-shaped microspring and the island structure. Furthermore, this innovative design could be easily extended to other flexible devices.

Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish.

Zebrafish and their mutant lines have been extensively used in biomedical investigations, cardiovascular studies, and drug screening. In the current study, the commercial version of the novel system, Zebra II, is presented. The protocol demonstrates electrocardiogram (ECG) acquisition and analysis from multiple zebrafish within controllable working environments. The device is composed of an external and independent perfusion system, a 4-point electrode, temperature sensors, and an embedded electronic system. In previous studies, the device prototype underwent validation against the established iWORX system through several tests, demonstrating similar data quality and ECG response to drug interventions. Following this, the study delved into examining the impact of anesthetic drugs and temperature fluctuations on zebrafish ECG, necessitating instant data evaluation. Thanks to the apparatus's capacity for consistent delivery of anesthetics and drugs, it was possible to extend ECG data collection up to 1 h, markedly longer than the 5 min duration supported by current systems. This paper introduces a pioneering, cloud-based, automated analysis utilizing data from four zebrafish, offering an efficient method for conducting combination experiments and significantly reducing time and effort. The system proved effective in capturing and analyzing ECG, especially in detecting drug-induced arrhythmias in wild-type zebrafish. Additionally, the capability to gather data across multiple channels facilitated the execution of randomized controlled trials with zebrafish models. The developed ECG system overcomes existing limitations, showing the potential to greatly expedite drug discovery and cardiovascular research involving zebrafish.

High Throughput Characterization of Organic Thin Film Transistors.

Automation is vital to accelerating research. In recent years,the application of self-driving labs to materials discovery and device optimization has highlighted many benefits and challenges inherent to these new technologies. Successful automated workflows offer tangible benefits to fundamental science and industrial scale-up by significantly increasing productivity and reproducibility all while enabling entirely new types of experiments. However, it's implemtation is often time-consuming and cost-prohibitive and necessitates establishing multidisciplinary teams that bring together domain-specific knowledge with specific skillsets in computer science and engineering. This perspective article provides a comprehensive overview of how the research group has adopted "hybrid automation" over the last 8 years by using simple automatic electrical testers (autotesters) as a tool to increase productivity and enhance reproducibility in organic thin film transistor (OTFT) research. From wearable and stretchable electronics to next-generation sensors and displays, OTFTs have the potential to be a key technology that will enable new applications from health to aerospace. The combination of materials chemistry, device manufacturing, thin film characterization and electrical engineering makes OTFT research challenging due to the large parameter space created by both diverse material roles and device architectures. Consequently, this research stands to benefit enormously from automation. By leveraging the multidisciplinary team and taking a user-centered design approach in the design and continued improvement of the autotesters, the group has meaningfully increased productivity, explored research avenues impossible with traditional workflows, and developed as scientists and engineers capable of effectively designing and leveraging automation to build the future of their fields to encourage this approach, the files for replicating the infrastructure are included, and questions and potential collaborations are welcomed.

Phase velocity shifts of shear surface waves in flexoelectric wave-guide clamped on piezomagnetic base

Surface acoustic wave devices featuring periodic layers of piezomagnetic and piezoelectric-flexoelectric layers are subject to intense investigation. In miniaturized devices, large strain gradients are possible that produce significant flexoelectric fields in piezoelectric components. In the present theoretical research, surface acoustic wave transference has been manifested in a flexoelectric waveguide clamped over a piezomagnetic base. This endeavor involves the formulation and solution of coupled magneto-electro-elastic field equations governing the structure’s behavior. Coupled magneto-electro-elastic field equations for the structure have been derived and solved utilizing analytical techniques. By accounting for pertinent boundary conditions, the dispersion relations characterizing the velocity of surface waves, both in scenarios with and without electrodes have been obtained. Based on proper numerical examples, the frequency and phase velocity spectrum have been plotted offering insights into key parameters i.e. modal frequency, phase velocity, and wave attenuation. The outcomes of the theoretical study may be helpful in providing insights into mechanical wave propagation in coupled piezoelectric/piezomagnetic structures.

Approaches for Targeting Naegleria fowleri Using Nanoparticles and Artificial Peptides.

Naegleria fowleri is a free-living amoeba which causes primary amoebic meningoencephalitis (PAM). Although PAM is rare, the fatality rate is staggering at over 97%. So, the importance of finding an effective treatment and cure for PAM caused by N. fowleri is a crucial area of research. Existing research on developing novel therapeutic strategies to counter N. fowleri infection is limited. Since the blood-brain barrier (BBB) presents an obstacle to delivering drugs to the site of infection, it is important to employ strategies that can effectively direct the therapeutics to the brain. In this regard, our review focuses on understanding the physiology and mechanisms by which molecules pass through the BBB, the current treatment options available for PAM, and the recent research conducted in the decade of 2012 to 2022 on the use of nanomaterials to enhance drug delivery. In addition, we compile research findings from other central nervous system (CNS) diseases that use shuttle peptides which allow for transport of molecules through the BBB. The approach of utilizing BBB shuttles to administer drugs through the BBB may open up new areas of drug discovery research in the field of N. fowleri infection.

Amphibious Hybrid Laser Tweezers for Fluid and Solid Domains.

Optical trapping is a potent tool for achieving precise and noninvasive manipulation of small objects in a vacuum and liquids. However, due to the substantial disparity between optical forces and interfacial adhesion, target objects should be suspended in fluid environments, rendering solid contact surfaces a restricted area for conventional optical tweezers. In this work, by relying on a single continuous wave (CW) laser, we demonstrate an optical manipulation system applicable for both fluid and solid domains, namely, amphibious hybrid laser tweezers. The key to our system lies in modulating the intensity of the CW laser with duration shorter than the dynamic thermal equilibrium time within objects, wherein strong thermal gradient forces with ∼6 orders of magnitude higher than the forces in optical tweezers are produced, enabling moving and trapping micro/nano-objects on solid interfaces. Thereby, CW laser-based optical tweezers and pulsed laser-based photothermal shock tweezers are seamlessly fused with the advantages of cost-effectiveness and simplicity. Our concept breaks the stereotype that CW lasers are limited to generating tiny forces and instead achieve ultrawide force generation spanning from femto-newtons (10-15 N) to (10-6 N). Our work expands the horizon of optical manipulation by seamlessly bridging its applications in fluid and solid environments and holds promise for inspiring optical manipulation techniques to perform more challenging tasks, which may unearth application scenarios in diverse fields such as fundamental physical research, nanofabrication, micro/nanorobotics, biomedicine, and cytology.

사회정서학습 연구에 대한 메타분석

Objectives The main limitations and characteristics of the times in domestic academic journal papers on social emotional learning are analyzed from a meta-analytical perspective, and research directions and implications for the development and revitalization of research in the field are presented. Methods This is a research based on systematic literature review, analysis criteria domestic academic journal papers. Results First, the number of publications showed a high rate of increase from the early period to the middle period, and research has decreased over the past three years. Second, the research purpose is a high proportion of empirical studies aimed at program development and effectiveness verification. The gap between study sections did not show much difference in the beginning, but rapidly increased in the middle section. Third, the research subjects were identified in the following order: learners, research products, instructors, and others. Research on learners and instructors is mainly conducted in the mid to late period. Fourth, in terms of school level, the elementary school level study showed the highest figure, and excluding others, it was confirmed to be middle school, high school, university, and infant school in that order. Fifth, research methods were focused on specific research methods, with quantitative research accounting for 44%, in that order: quantitative research, literature research, qualitative research, and mixed research. Conclusions First, social-emotional learning research is expected to become active, and this positive trend should continue. Second, the imbalance between theoretical and empirical research must be improved. Third, following research targeting learners who are consumers of education, research conducted from the perspective of instructors should be expanded. Fourth, there is a need to expand research to various school levels, including preschool levels, by utilizing the results of elementary school level research. Fifth, as with the research purpose, the focus on research methods must be overcome.

Assessing residential sustainable energy autonomous buildings for hot climate applications

This paper introduces an innovative solution for clean energy autonomous building (AB) sustainability, offering a 5Z concept—zero-carbon, zero-energy, zero grid connections, zero energy bills, and zero emission mobility. This paper focuses on fundamental research to design sustainable, energy-ABs striving for self-sufficiency in arid climates, using Kuwait as a case study. The study highlights the importance of stringent engineering AB modeling, renewable technology integration, and clean energy storage. The technical approaches include characterizing non-thermal and thermal demands, achieving net-zero energy generation, and custom sizing renewable energy and energy storage systems (ESS) for electric vehicle (EV) charging points. The research methodology involves local construction with yearly weather and energy profile data to simulate the actual system using ESP-r building model. The study's findings reveal the need for a large-scale energy system, energy demand reduction (EDR) inclusive of heating, cooling, appliances, and EV, with the corresponding changes in local energy production system size, battery capacity, and the number of photovoltaics (PVs). The results show varying EDR levels ranging from base case to 10% and to 50% leading to proportional changes in energy system size, size of battery from 3415 kWh to 1710 kWh and the number of PVs from 362 to 181, which means EDR not only optimizes space but also proves cost-effective. The significant implication of this study, not only bridging the knowledge gap and the lack of how-know, but also making a significant advancement and forward thinking in sustainable green electric home modernization and environmentally friendly transportation. This approach transforms energy management practices for more sustainable cities and societies, reducing emissions in both urban infrastructure and transportation.

From darkness to light, from subject erasure to validation: personal writing by childhood victims of sexual abuse and sharing in therapeutic writing communities

ABSTRACT The article reviews the current theoretical research on writing in the aftermath of childhood sexual trauma and the role of writing and of sharing in therapeutic online writing communities. This paper presents a qualitative narrative study that included analysis of 54 texts written and shared on the internet. The paper suggests that personal writing by childhood victims of sexual abuse and online sharing of their texts facilitate testimony and rehabilitation of the abused and erased self. In the discussion of the research findings, I focus on the role of writing in revealing the truth, and the possibility of existing in a dialectics of trauma. The paper demonstrates this through the salient theme of silence and speech. The theoretical contribution of the study to the fields of bibliotherapy and poetry therapy is in understanding the role and meanings of writing and of sharing in therapeutic writing communities.

Research on the Driving Effect of Smart City Construction on Regional Economic Development

As a new model of modern urban development, smart cities are promoting the sustainable development of regional economies through the deep integration of information technology and urban construction. This study, titled "Research on the Driving Effect of Smart City Construction on Regional Economic Development," systematically analyzes the theoretical foundation, current implementation status, and impact mechanisms of smart city construction on regional economic development. By comparing successful cases domestically and internationally, the study reveals the specific effects of smart city construction on optimizing resource allocation, upgrading industrial structures, and driving innovation. Using econometric models to analyze empirical data on smart city construction, the results indicate that smart city construction significantly promotes the coordinated development and competitiveness of regional economies. The study concludes with policy recommendations to further smart city construction and regional economic development, including strengthening government guidance, promoting corporate innovation, and optimizing public services, providing scientific guidance and references for smart city construction. The findings not only enrich the theoretical research in the fields of smart city and regional economic development but also offer valuable insights for practical policy-making.

A Theoretical Study on the Influence of Five- and Six-Membered N-Heterocyclic Ring Side Chains of the N-Donor Extractants on Am(III)/Eu(III) Extraction and Separation.

According to the green development requirements of carbon neutrality and carbon peaking, the effective separation of lanthanides and actinides is one of the key factors for nuclear energy to become a sustainable energy source. In recent years, o-phenanthroline-based ligands have been proven to be effective in the separation of lanthanides and actinides. In this work, based on 5,9b-dihydro-4aH-cyclopenta[1,2-b:5,4-b']dipyridines, we designed six N-heterocyclic ring ligands and theoretically studied their extraction capacity and separation selectivity for the Am(III) and Eu(III) ions. Various theoretical methods were used to analyze the properties of the ligands and study the bonding nature of the ligands with the metal ions. Thermodynamic parameters were calculated to measure the extraction ability of the ligands to the metal ions and to explore the separation capacity of the ligand for the Am(III) and Eu(III) ions. The calculated results show that the five- and six-membered N-heterocyclic ring side chains of the ligands and the distribution of the N atoms on the side chain rings have obvious effects on the bonding of the ligands to metal ions and on the extraction and separation properties of the ligands for the metal ions. It was found that the extractants with six-membered ring side chains possess an extraction ability slightly better than that of the ligands with five-membered ring side chains and that the ligands with a pair of adjacent N atoms on the side chains have a stronger separation selectivity for the Am(III)/Eu(III) ions. The theoretical research in this work will help to understand the details of binding and extraction properties of similar ligands and provide insights for the future design of five- and six-membered heterocyclic ligands.

Exciton-harvesting enabled efficient charged particle detection in zero-dimensional halides

Materials for radiation detection are critically important and urgently demanded in diverse fields, starting from fundamental scientific research to medical diagnostics, homeland security, and environmental monitoring. Low-dimensional halides (LDHs) exhibiting efficient self-trapped exciton (STE) emission with high photoluminescence quantum yield (PLQY) have recently shown a great potential as scintillators. However, an overlooked issue of exciton-exciton interaction in LDHs under ionizing radiation hinders the broadening of its radiation detection applications. Here, we demonstrate an exceptional enhancement of exciton-harvesting efficiency in zero-dimensional (0D) Cs3Cu2I5:Tl halide single crystals by forming strongly localized Tl-bound excitons. Because of the suppression of non-radiative exciton-exciton interaction, an excellent α/β pulse-shape-discrimination (PSD) figure-of-merit (FoM) factor of 2.64, a superior rejection ratio of 10−9, and a high scintillation yield of 26 000 photons MeV−1 under 5.49 MeV α-ray are achieved in Cs3Cu2I5:Tl single crystals, outperforming the commercial ZnS:Ag/PVT composites for charged particle detection applications. Furthermore, a radiation detector prototype based on Cs3Cu2I5:Tl single crystal demonstrates the capability of identifying radioactive 220Rn gas for environmental radiation monitoring applications. We believe that the exciton-harvesting strategy proposed here can greatly boost the applications of LDHs materials.

Determining the coordinates of unmanned aerial vehicles

The purpose of the work was to develop a method for determining unmanned aerial vehicles’ (UAVs) coordinates, trajectory and parameters of their spatial movements by means of kinematic projection. The paper analyses the use of technologies for determining coordinates and spatial movements of aircraft trajectories. The principle of the kinematic scheme of fixing moving objects by means of orthogonal and kinematic design has been developed. The principle scheme of determining UAV coordinates by kinematic projection was studied. The theoretical mathematical dependencies of the determination and calculations of the coordinates of spatial movements of unmanned aerial vehicles have been practically verified. The main object of research in this work was the theory of kinematic design as a means of graphically displaying the patterns of spatial movements of objects. The subject of the study was the specific features of searching and recording the trajectories of spatial movements of unmanned aerial vehicles in order to determine the coordinates of their instantaneous location in space. In the process of conducting theoretical and experimental research, methods and techniques of physical and mathematical modelling of fast-moving processes and mathematical statistics of analysis and classification of their results were used. The basis of the experimental study was the theory of mapping coordinates and trajectories of spatial movements of moving objects by means of graphic geometry when combining classical orthogonal design with dynamic features of kinematic design. For an objective assessment of the results of the theoretical and experimental study of the dynamics of objects moving in space, the classical theory of research planning with a mathematical apparatus for processing their results was used. Graphical models of UAV coordinate fixation were made with the use of computer technology and the AutoCAD graphic editor software.

Perbuatan Kelalaian Oleh Konsultan Pengawas Konstruksi Atas Bangunan Yang Menyebabkan Kerugian Negara

Construction supervision consultants are essential for infrastructure and construction projects that involve public funds. Construction supervision consultants are responsible for ensuring that projects run according to standards, comply with regulations, and reduce the risk of failure or accidents. Negligence committed by construction supervision consultants includes lack of supervision of project implementation to the point of not complying with established quality and safety standards. This study utilizes normative research methods, also known as legal research methods, positive legal research methods, doctrinal legal research methods, and pure legal research methods. During a construction project, the supervising consultant ensures that all work is carried out in accordance with the established technical specifications and quality standards. Ensuring that all projects are executed with professionalism and regulatory compliance, the consultant is responsible for reporting and documenting all important aspects of the project as well as managing changes that may occur during the construction process. The concept of negligence includes various types of non-compliance with technical standards, inaccurate planning, negligence in supervision and monitoring, corruption, and opacity in the construction process. The negligence of construction supervision consultants can negatively impact the success of the construction project itself.

Evaluation of wear and friction properties of graphite modified Lubri polylactic acid with various infill fabricated by additive manufacturing techniques

AbstractThree‐dimension (3D) printing technology, also known as additive manufacturing, is a manufacturing technology that creates three‐dimensional objects by depositing material layer by layer, as opposed to subtractive manufacturing methods. However, the newness of the technology brings with it many unknowns. In particular, the raw materials used are constantly increasing. For this reason, testing each raw material used in many aspects and to determine the optimum production conditions is important for the wide use of 3D printing technology. These optimal conditions may be the parameters used to produce a material, and sometimes they can appear as a new material. In addition, the production of new materials with varying production parameters is fundamental research topic that requires comprehensive study. For all these purposes, in this study, a new material type known as Lubri PLA (LPLA) was selected and produced in different filling types and subjected to a series of friction and wear tests. Thus, it is aimed to determine the tribological properties of the material. Additionally, samples were produced in ten different infill types (grid, lines, triangels, hexagon, cubic, octal, zigzag, diagonal, diagonal 3D and gyroid) to show the effect of filler type on friction and wear behavior. These filler types were used for both PLA and Lubri PLA materials and a total of twenty samples were produced. Thereby, it is aimed to conduct a comprehensive study showing the effect of both material difference and filling type on friction‐wear behavior. Diameter deviations, hardness deviations, friction coefficient, temperature, specific wear rates (SWr), and vibration were selected as output parameters. According to the analysis of the test results, the best result in terms of material structure was given by Lubri PLA, while the best result in terms of filling type was obtained with Diagonal 3D filling type. In addition, the lowest vibration level was obtained in the LP‐Diagonal 3D sample with 0.041 mm/s2, while the highest vibration level was obtained in the P‐Grid sample with 1.756 mm/s2.Highlights LPLA closed to nominal value in diameter and hardness deviations Addition of graphite nanoparticle increased the dimensional accuracy Diagonal 3D infill type Lubri PLA composites showed the superior performance Graphite modified Lubri PLA composites demonstrated superior performance