A theoretical research program is outlined that seeks to use the Modern Synthesis in explaining human evolution, but also recognizes its limitations in explaining the evolution of socio-cultural systems. The universe, from a human perspective, is composed of physical, biological, and socio-cultural dimensions, each revealing unique properties and dynamics. In the case of the socio-cultural universe, modern evolutionary theory is relevant for some explanations, but not to the degree assumed by socio-biology, evolutionary psychology, and even co-evolutionary models. The program proposed is built around social network theory, cladistic analysis, and comparative neuro-anatomy, and outlines where biological analysis is appropriate and useful. An understanding of the biological basis of human behavior will allow sociologists to develop theoretical approaches to explaining the emergent properties of the socio-cultural universe. The strategy outlined will allow us to see what a mature evolutionary sociology can do: develop abstract theoretical laws about the dynamics of selection on socio-cultural formations in human societies.