Predestination, good and evil, human responsibility, and mission. The background of this article is the challenge that Paul deals with in Romans, namely predestination and the reference to good and evil in theology. It seems as if God ordained good and evil. God is, however, holy and totally good. Sources by Augustine, Calvin, Weaver, Van de Beek and others highlight the questions in this regard. The central implications of the cross of Jesus, as well as the issue of human responsibility are extremely relevant in this regard. The objectives are to give a sound theological evaluation of the question of good and evil from the perspective of reformed theology in interaction with Scripture. Interaction with Scripture and theologians leads to a literature study and thereafter exegetical, hermeneutical and systematic theology issues are addressed. The results established that different positions are taken, but God is just and not the author of sin. This implicates a clear view on mission: reject sin and turn to God. The conclusions are: God is holy, but all mankind should reject evil and accept that God is the fountian of good. Mission is the act of the Triune God (missio Dei) in Jesus Christ, through the Holy Spirit, to lead sinners from darkness to God. The good in Jesus Christ, by his death on the cross and in his resurrection, overcame evil.Contribution: The article illuminates the issue of good and evil in a new way and offers insight into its significance for the mission. This has significance for the current missiological engagement.