Theme Issue Research Articles

Biotic interactions, evolutionary forces and the pan-plant specialized metabolism.

Plant specialized metabolism has a complex evolutionary history. Some aspects are conserved across the green lineage, but many metabolites are unique to certain lineages. The network of specialized metabolism continuously diversified, simplified or reshaped during the evolution of streptophytes. Many routes of pan-plant specialized metabolism are involved in plant defence. Biotic interactions are recalled as major drivers of lineage-specific metabolomic diversification. However, the consequences of this diversity of specialized metabolism in the context of plant terrestrialization and land plant diversification into the major lineages of bryophytes, lycophytes, ferns, gymnosperms and angiosperms remain only little explored. Overall, this hampers conclusions on the evolutionary scenarios that shaped specialized metabolism. Recent efforts have brought forth new streptophyte model systems, an increase in genetically accessible species from distinct major plant lineages, and new functional data from a diversity of land plants on specialized metabolic pathways. In this review, we will integrate the recent data on the evolution of the plant immune system with the molecular data of specialized metabolism and its recognition. Based on this we will provide a contextual framework of the pan-plant specialized metabolism, the evolutionary aspects that shape it and the impact on adaptation to the terrestrial environment.This article is part of the theme issue 'The evolution of plant metabolism'.

The evolution of plant responses underlying specialized metabolism in host-pathogen interactions.

In the course of plant evolution from aquatic to terrestrial environments, land plants (embryophytes) acquired a diverse array of specialized metabolites, including phenylpropanoids, flavonoids and cuticle components, enabling adaptation to various environmental stresses. While embryophytes and their closest algal relatives share candidate enzymes responsible for producing some of these compounds, the complete genetic network for their biosynthesis emerged in embryophytes. In this review, we analysed genomic data from chlorophytes, charophytes and embryophytes to identify genes related to phenylpropanoid, flavonoid and cuticle biosynthesis. By integrating published research, transcriptomic data and metabolite studies, we provide a comprehensive overview on how these specialized metabolic pathways have contributed to plant defence responses to pathogens in non-vascular bryophytes and vascular plants throughout evolution. The evidence suggests that these biosynthetic pathways have provided land plants with a repertoire of conserved and lineage-specific compounds, which have shaped immunity against invading pathogens. The discovery of additional enzymes and metabolites involved in bryophyte responses to pathogen infection will provide evolutionary insights into these versatile pathways and their impact on environmental terrestrial challenges.This article is part of the theme issue 'The evolution of plant metabolism'.

The evolution of flavonoid biosynthesis.

The flavonoid pathway is characteristic of land plants and a central biosynthetic component enabling life in a terrestrial environment. Flavonoids provide tolerance to both abiotic and biotic stresses and facilitate beneficial relationships, such as signalling to symbiont microorganisms, or attracting pollinators and seed dispersal agents. The biosynthetic pathway shows great diversity across species, resulting principally from repeated biosynthetic gene duplication and neofunctionalization events during evolution. Such events may reflect a selection for new flavonoid structures with novel functions that enable occupancy of varied ecological niches. However, the biochemical and genetic diversity of the pathway also likely resulted from evolution along parallel trends across land plant lineages, producing variant compounds with similar biological functions. Analyses of the wide range of whole-plant genome sequences now available, particularly for archegoniate plants, have enabled proposals on which genes were ancestral to land plants and which arose within the land plant lineages. In this review, we discuss the emerging proposals for how the flavonoid pathway may have evolved and diversified. This article is part of the theme issue 'The evolution of plant metabolism'.

Exploring Port City Porosity and Flows within Port Regions: The Case Study of Port of Malaga and Port of Beirut

The term “porosity” refers to the idea of interconnectedness between the spaces and institutions of ports, cities, and their surrounding areas. While porosity refers to the overall interconnectedness between different entities, an interface specifically refers to the point of contact and interaction between the same two entities. This paper goes beyond the idea of an interface and emphasizes a continuous network of port-related spaces and practices that shape the port cityscape. It also provides a historical perspective on the evolution of port/city boundaries. Additionally, this paper explores maps and conceptualizes port city porosity on both sea and land sides, measures, and reconsiders porosity in these regions. The thematic issue opens questions for further research such as: Can the interconnectedness between port and city areas, along with maritime pockets in the city and surrounding territory, enhance the resilience of port city activities? Does the existence of porous borders between port and city allow for easier transitions? The idea of transitions is particularly relevant in the context of the dynamic and ever-changing nature of port and city activities. As economic, social, or environmental conditions shift, there may be a need for both the port and city to adapt and evolve. The degree of porosity between them can play a role in facilitating or hindering these transitions.

Digital In- and Exclusion in Everyday Life: Practices and Literacies Across the Lifespan

In this thematic issue of <em>Media and Communication</em> titled Practices of Digital In- and Exclusion in Everyday Life, we bring together insights from around the world to offer a diverse set of perspectives on digital practices and digital literacies across the lifespan. Moreover, emphasizing the development of digital literacies as a situated social practice, this thematic issue provides insights into the social contexts through which people develop digital literacy practices, how they construct and integrate social norms around technologies, and the links between digital literacies and (digital) citizenship. As concerns about digital in- and exclusion grow, this thematic issue hosts numerous relevant studies by academics that collectively help us gain insight into the impact of digital in- and exclusion in everyday life across the lifespan, gaining insight into the role of different contextual factors, including time, place, and social, economic, and political contexts in the ways in which citizens use digital media and develop digital literacies.

Navigating Social Boundaries and Belonging: People Without Migration Background in Majority–Minority Cities

This editorial introduces the articles in this thematic issue, which revolves around the ERC Advanced research project Becoming a Minority (BaM), carried out between 2018 and 2023. The aim of the project was to understand how people without a migration background think about and live in diversity. Through this aim, the BaM project has tried to advance our thinking about the concept of integration.

Introduction to the Special Theme issue “Innovative, Interactive, and Intelligent Uses of Technology in Multilingual Classrooms”

Introduction to the Special Theme issue “Innovative, Interactive, and Intelligent Uses of Technology in Multilingual Classrooms”

The Geoeconomic Turn in International Trade, Investment, and Technology

This thematic issue brings together a set of articles that empirically map the state of the ongoing geoeconomic turn in the global political economy from an international political economy (IPE) perspective. Changes in the modus operandi of the global political economy urge the development of new conceptual and theoretical tools to grasp the new geoeconomic reality of world affairs. At the same time, the contemporary study of geoeconomics remains theory-centred and focused on its security dimension, thereby underplaying the empirical nuances and variegated aspects of these developments. We therefore make the case for an empirically grounded study of concrete cases and instances of the geoeconomic turn, which can then deliver insights for further theory-building. Likewise, many aspects of the geoeconomic turn cannot be explained by security logics only, but have political economy roots that need to be brought to the foreground. Our thematic issue excavates these dynamics across four key challenges for the global economy: the role of states and firms in a geoeconomic world; global technological competition; the green transition; and implications of the geoeconomic turn for the non-Western world. Collectively, the contributions demonstrate that the geoeconomic turn is only starting to concretely (and partially) materialize and that these transformations, in many cases, tend to replicate existing power structures that prioritize capital(ist) interests related to profit-maximisation over societal interests, ecological sustainability, or social equity. We close by delineating prospects for further IPE research into the ongoing geoeconomic turn in the global political economy.

The Ongoing Challenge of Digital Technology Innovation

This special theme issue of NEJM Catalyst Innovations in Care Delivery, guest edited by Rasu Shrestha, MD, MBA, includes articles, case studies, and research reports on digital technology adoption, the uses of artificial intelligence, in-basket workflow, telehealth-enabled nursing, and digitally enabled care.

Einleitung: Gewohnheit, Erfahrung und die ‚schreibende Frau‘

Abstract This introduction summarizes some of the main hypotheses that underly the contributions of this thematic issue of ARTES which is dedicated to the role of habit/custom and experience in the writing of some Early Modern women authors. One hypothesis is that references to habit and experience may have supported Early Modern women writers in their efforts to legitimize their arguments, knowledge and writing, the reason for this being that – due to various social restrictions and expectations – women were often denied access to other fields of knowledge, especially that of so-called book knowledge. Hence, the question arises to what extent the references to habit/custom and experience are connected to the question of female education and female strategies of (self-)empowerment. I will illustrate this using the prominent example of the medieval writer Christine de Pizan. Since the specific nature of female claims can only be assessed against the background of male writing practices, I will also make some introductory remarks on habit/custom and experience with reference to Early Modern male authors.

The function of episodic memory in animals.

The best-known example of episodic memory in animals came from food-storing birds. One of the beauties of the food-storing system was that inherent in the behaviour were the elements that (at the time) made up episodic memory: what, where and when. While there were then already plenty of data on animals' ability to put together what and where, the addition of the time element in animals' memory and its testing was one that was both new and experimentally challenging. It has, however, led to an increasing variety of examples showing that animals can put together all three informational components. If episodic memories can be described as those memories that make any one of us who we are, why should non-human animals have such memories? Here, we argue that episodic memories play a significant functional role in the lives of real animals, in particular, enabling them to make decisions about how they might or should act in their future. We support our argument with data from a range of examples, focussing on data from the field.This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

Children's mental time travel into the future: a functional perspective.

Children's episodic future-thinking is typically assessed using experimental tasks that measure whether children select an item with future utility. Although these tasks-inspired by Tulving's seminal 'spoon test' (Tulving E. 2005 Episodic memory and autonoesis: uniquely human? In The missing link in cognition: origins of self-reflective consciousness [eds HS Terrace, J Metcalfe], pp. 3-56. Oxford, UK: Oxford University Press. [doi:10.1093/acprof:oso/9780195161564.001.0001])-are passed around age 4, they tell us little about the functional significance of children's episodic future-thinking in their day-to-day lives. We highlight how a naturalistic approach can shed light on this issue, and present a small study where we recruited mothers to report on their children's (N = 12, 3- and 4-year-olds and 6- and 7-year-olds) future-thinking over a 7-day period. We used a thematic analysis to understand why children express future thoughts and derived the following themes: (1) expressing future desires and/or intentions, (2) future-oriented information-seeking, (3) connecting present actions with future outcomes, and (4) predicting future mental/physiological states. We compare these themes with recent accounts of the functional significance of future-thinking in adults and conclude that children largely express their future-thinking verbally to request information or support from their parent-likely because they do not yet possess enough control/autonomy to independently act for their own future. Our findings both complement and extend an experimental approach and further elucidate the functional significance of mental time travel in children. This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

Measuring episodic memory and mental time travel: crossing the species gap.

Mental time travel is the projection of the mind into the past or future, and relates to experiential aspects of episodic memory, and episodic future thinking. Framing episodic memory and future thinking in this way causes a challenge when studying memory in animals, where demonstration of this mental projection is prevented by the absence of language. However, there is good evidence that non-human animals pass tests of episodic memory that are based on behavioural criteria, meaning a better understanding needs to be had of the relationship between episodic memory and mental time travel. We argue that mental time travel and episodic memory are not synonymous, and that mental time travel is neither a requirement of, nor an irrelevance to, episodic memory. Mental time travel can allow improved behavioural choices based on episodic memory, and work in all species (including humans) should include careful consideration of the behavioural outputs being measured. This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

Beyond the episodic-semantic continuum: the multidimensional model of mental representations.

Tulving's concept of mental time travel (MTT), and the related distinction of episodic and semantic memory, have been highly influential contributions to memory research, resulting in a wealth of findings and a deeper understanding of the neurocognitive correlates of memory and future thinking. Many models have conceptualized episodic and semantic representations as existing on a continuum that can help to account for various hybrid forms. Nevertheless, in most theories, MTT remains distinctly associated with episodic representations. In this article, we review existing models of memory and future thinking, and critically evaluate whether episodic representations are distinct from other types of explicit representations, including whether MTT as a neurocognitive capacity is uniquely episodic. We conclude by proposing a new framework, the Multidimensional Model of Mental Representations (MMMR), which can parsimoniously account for the range of past, present and future representations the human mind is capable of creating. This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

A short natural history of mental time travels: a journey still travelled?

Tulving's introduction of episodic memory and the metaphor of mental time travel has immensely enriched our understanding of human cognition. However, his focus on human psychology, with limited consideration of evolutionary perspectives, led to the entrenched notion that mental time travel is uniquely human. We contend that adopting a phylogenetic perspective offers a deeper insight into cognition, revealing it as a continuous evolutionary process. Adherence to the uniqueness of pre-defined psychological concepts obstructs a more complete understanding. We offer a concise natural history to elucidate how events that occurred hundreds of millions of years ago have been pivotal for our ability to mentally time travel. We discuss how the human brain, utilizing parts with ancient origins in a networked manner, enables mental time travel. This underscores that episodic memories and mental time travel are not isolated mental constructs but integral to our perception and representation of the world. We conclude by examining recent evidence of neuroanatomical correlates found only in great apes, which show great variability, indicating the ongoing evolution of mental time travel in humans.This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

Episodic memory without autonoetic consciousness.

Ever since Tulving's influential 1985 article 'Memory and consciousness', it has become traditional to think of autonoetic consciousness as necessary for episodic memory. This paper questions this claim. Specifically, it argues that the construct of autonoetic consciousness lacks validity and that, even if it was valid, it would still not be necessary for episodic memory. The paper ends with a proposal to go back to a functional/computational characterization of episodic memory in which its characteristic phenomenology is a contingent feature of the retrieval process and, as a result, open to empirical scrutiny. The proposal also dovetails with recent taxonomies of memory that are independent of conscious awareness and suggests strategies to evaluate within- and between-individual variability in the conscious experience of episodic memories in human and non-human agents. This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

Schema-driven prediction effects on episodic memory across the lifespan.

The predictive processing framework posits that one of the main functions of the brain is to anticipate the incoming information. Internal models facilitate interactions with the world by predicting future states against which actual evidence is compared. The difference between predicted and actual states, the prediction error (PE), signals novel information. However, how PE affects cognitive processing downstream is not fully understood: one such aspect pertains to how PE influences episodic memories, and whether those effect on memory differ across the lifespan. We examine the relationship between PE and episodic memory in children, young and older adults. We use a novel paradigm whereby rich visual narratives are used to build action schemas that enable probing different mnemonic aspects. To create different levels of PE, we manipulate the story endings to be either expected, neutral or unexpected with respect to the unfolded action. We show that (i) expected endings are better encoded than neutral endings and (ii) unexpected endings improve the encoding of mismatching events and other aspects of the narrative. These effects are differentially modulated across the lifespan with PE-driven encoding being more prominent in children and young adults and with schema integration playing a larger role on memory encoding in older adults. These results highlight the role of predictions by enriching past experiences and informing future anticipations.This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

The history of episodic memory.

Over the course of his research, Endel Tulving offered a number of somewhat different characterizations of episodic memory. Do they indicate that he changed his mind over time as to what episodic memory is, or did his core understanding of the nature of episodic memory stay the same? In this article, we offer some support for the latter claim, and in particular for thinking that, throughout his life, Tulving took as a defining feature of episodic memory the distinctive awareness of the self in time it involves. We argue that it is easier to see the continuities rather than the discontinuities in Tulving's writings once their historical context is taken into account, where this involves both the authors who influenced his thinking, as well as the intellectual climate at the different times he was writing. We also discuss two recent bodies of work on episodic memory that take aspects of Tulving's writings as their point of departure, but try to factor out into separate ingredients what he arguably saw as a unitary phenomenon. Considering aspects of the dialectic between them and Tulving's view might shed further light on some of the motivations behind the latter.This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

Eliminating episodic memory?

In Tulving's initial characterization, episodic memory was one of multiple memory systems. It was postulated, in pursuit of explanatory depth, as displaying proprietary operations, representations and substrates such as to explain a range of cognitive, behavioural and experiential phenomena. Yet the subsequent development of this research programme has, paradoxically, introduced surprising doubts about the nature, and indeed existence, of episodic memory. On dominant versions of the 'common system' view, on which a single simulation system underlies both remembering and imagining, there are no processes unique to memory to support robust generalizations with inductive potential. Eliminativism about episodic memory seems to follow from the claim that it has no dedicated neurocognitive system of its own. After identifying this under-noticed threat, we push back against modern eliminativists by surveying recent evidence that still indicates specialized mechanisms, computations and representations that are distinctly mnemic in character. We argue that contemporary realists about episodic memory can retain lessons of the common system approach while resisting the further move to eliminativism. This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

Mental time travel in animals: the 'when' of mental time travel.

While many aspects of cognition have been shown to be shared between humans and non-human animals, there remains controversy regarding whether the capacity to mentally time travel is a uniquely human one. In this paper, we argue that there are four ways of representing when some event happened: four kinds of temporal representation. Distinguishing these four kinds of temporal representation has five benefits. First, it puts us in a position to determine the particular benefits these distinct temporal representations afford an organism. Second, it provides the conceptual resources to foster a discussion about which of these representations is necessary for an organism to count as having the capacity to mentally time travel. Third, it enables us to distinguish stricter from more liberal views of mental time travel that differ regarding which kind(s) of temporal representation is taken to be necessary for mental time travel. Fourth, it allows us to determine the benefits of taking a stricter or more liberal view of mental time travel. Finally, it ensures that disagreement about whether some species can mentally time travel is not merely the product of unrecognized disagreement about which temporal representation is necessary for mental time travel. We argue for a more liberal view, on the grounds that it allows us to view mental time travel as an evolutionarily continuous phenomenon and to recognize that differences in the ways that organisms mentally time travel might reflect different temporal representations, or combinations thereof, that they employ. Our ultimate aim, however, is to create a conceptual framework for further discussion regarding what sorts of temporal representations are required for mental time travel.This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.