Thecoma Research Articles

Theca-cell tumors of the ovary

Four additional examples of theca-cell tumors of the ovary have been reported, three being removed surgically, one having been discovered incidental to autopsy. All the tumors were benign. One very large tumor occurred in a 17-year-old girl, producing no menstrual irregularities. One tumor associated with a fibroma of the opposite ovary showed infarction due to torsion of its pedicle. Convalescence and follow-up of the three cases have been uneventful.A complete summary of the literature has been presented.

Thecoma of the Ovary with Ascites and Hydrothorax (Meigs’ Syndrome)

Thecoma of the Ovary with Ascites and Hydrothorax (Meigs’ Syndrome)

Theca cell tumor of the ovary and carcinoma of the endometrium

Theca cell tumor of the ovary and carcinoma of the endometrium

Granulosa and theca cell tumors of the ovary: With a report of thirty cases

Thirty ovarian tumors belonging to the granulosa and theca cell group of neoplasms are reported. They correspond in age incidence, clinical manifestations, and in gross and microscopic appearance with other reported cases. They differ in one major respect, that of malignancy. Only one tumor has proved to be malignant despite a follow-up record of four years or longer in 14 cases. By means of Laidlaw's silver stain granulosa-like cells were identified in all theca cell tumors and thecalike cells in a number of granulosa cell neoplasms. While our results are similar to those reported by Traut and Marchetti, we are not yet completely satisfied in regard to the recognition of these two types of cells by this method. Tumors of the theca cell group, however, had a later age incidence and presented sufficiently well-marked pathologic differences to warrant their continued recognition as a particular type of estrogen-secreting tumor. Two of the granulosa cell tumors were completely luteinized and one of these was of the unusual adenomatous type. The occurrence of 5 cases of carcinoma of the endometrium and 10 cases of uterine fibroids suggests a direct relationship between the ovarian neoplasm and the uterine tumors but does not warrant a definite conclusion in this regard.

Theca cell tumor of ovary and endometrial carcinoma

Theca cell tumor of ovary and endometrial carcinoma

Theca Cell Tumors of the Ovary

Theca Cell Tumors of the Ovary

VAGINAL ESTRUS IN IRRADIATED MICE RELATIONSHIP OF VAGINAL ESTRUS TO OVARIAN CHANGES AND PRODUCTION OF BIOLOGICALLY ACTIVE OVARIAN TUMORS AFTER ROENTGEN IRRADIATION

IN A PREVIOUS COMMUNICATION, the experimental production of biologically active ovarian tumors in mice by roentgen irradiation was reported (I). Granulosa and theca cell neoplasms with varying degrees of luteinisation were found to occur in a number of mice during periods of 10 to 15 months following irradiation. Histogenetically, these tumors appeared to have been derived from undifferentiated ovarian parenchyma. Their estrogenic hormonal activity was expressed in proliferative changes within the endometrial and vaginal mucosa. Since these tumors were comparable in structure and function to the granulosa cell neoplasm, its excessively luteinised variety, the Lecene tumor, and the theca cell tumor of the human ovary, an analogous derivation from ovarian parenchyma was postulated. In the course of this study, animals were killed at frequent intervals during the many months prior to tumor development, permitting a correlation between the histopathology of the ovary, the uterine endometrium and the vaginal m...

Theca cell tumors of the ovary: A report of ten cases

The clinical and pathologic data on 10 so-called theca cell tumors have been presented. These tumors occur most frequently following the menopause. They resemble granulosa cell tumors clinically, but pathologically possess certain distinguishing features which probably justify their consideration as an entity.

A study of the reticulum and of luteinization in granulosa and theca cell tumors of the ovary

1.1. In the Graafian follicle and corpus luteum, as well as in tumors containing theca and granulosa cells, the relationship of the reticulum furnishes a means of identifying the two types of cells. The theca cells are always individually surrounded by this connective tissue element, whereas granulosa cells and lutein cells are enclosed not at all, or as groups of cells.2.2. Granulosa and theca cell tumors are not only closely related, but in all probability, most human granulosa cell tumors contain varying proportions of both types of cells.3.3. These tumors undergo luteinization in the same manner as does the Graafian follicle. The cause of luteinization is not known, excepting that it is found in the older tumors of the mouse's ovary and may be therefore an expression of age or maturity.4.4. The phospholipid content of the tumors is low per unit of weight, as compared with that of the corpus luteum. This may, in part, be due to the greater connective tissue content and areas of degeneration.5.5. The life cycle of the granulosa cells, together with the fact that the tumor composed of them contains foci which differ widely in degrees of maturity, explains some of the clinical phenomena observed in patients harboring this type of growth.6.6. Luteinization of granulosa cell tumors in small or moderate degree is common. Seventeen instances reported in the literature have been found where the major portion of the tumor had undergone lipoid change. Complete luteinization is rare and is usually found in small tumors.7.7. If allowed to mature, one of three different terminations is thought to be the end of the life cycle of granulosa cell tumors: (a) luteinization followed by lipoid degeneration; (b) ischemic necrosis; and (c) collagenous degeneration followed by fibrosis. In tumors composed chiefly of theca elements, collagenous degeneration and fibrosis are the usual sequelae to the luteinization phase.

Experimental biologically active ovarian tumors in mice: Histogenesis and relationship to similar human ovarian tumors

X-ray irradiation of mice at puberty results in the production of two types of ovarian tumors: tubular adenomas derived from the surface epithelium and parenchymal lutein tumors.The parenchymal lutein tumors alone exhibit hormonal activity expressed in proliferative changes in the endometrium and vaginal mucosa.Histologically, these tumors are composed of granulosa and theca cells with varying degrees of luteinization. They are entirely comparable to the granulosa cell tumor and its excessively luteinized variant, the Lecène tumor, and the theca cell tumor of the human ovary.The luteinized ovarian tumors in mice are derived from the undifferentiated parenchyma. While the theca interna cells participate in the early proliferation and luteinization, the mature granulosa cells play no role in the genesis of these neoplasms.The histogenesis of the analogous human tumors may well be identical.

A case of theca-cell tumor of the ovary in a woman aged 92 years: Patterson and McCullagh: J. Obst. & Gynaec. Brit. Emp. 43: 1186, 1936

A case of theca-cell tumor of the ovary in a woman aged 92 years: Patterson and McCullagh: J. Obst. & Gynaec. Brit. Emp. 43: 1186, 1936

Theca cell tumor of the ovary

A definite case of a ruptured theca cell tumor of the ovary occurring in a young woman and characterized by a prolonged amenorrhea is hereby reported. With oophorectomy, there was a complete regression of symptoms. It is our hope to report, at a later date, the results of a biochemical assay of this tissue.

Theca cell tumors

The anatomic and histologic characteristics of theca cell tumors are described, together with their distinctive clinical and hormonal features. Descriptions are given of six cases illustrating variations from the more benign fibroma type to the highly cellular and malignant type. A correlation is made between the presence of hormonal changes and the presence of intracellular, doubly refractile fat containing cholesterol and cholesterol esters. It is suggested that some of the ovarian neoplasms previously diagnosed as fibromas or fibrosarcomas may on further investigation prove to be of theca cell origin.

Theca Cell Tumor of the Ovary

Journal Article Theca Cell Tumor of the Ovary Get access J. Marshall Neely J. Marshall Neely Lincoln General Hospital, Lincoln, Nebraska Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 7, Issue 4, 1 July 1937, Pages 293–299, https://doi.org/10.1093/ajcp/7.4.293 Published: 01 July 1937 Article history Received: 14 June 1936 Published: 01 July 1937

A study of fibromyomas of the uterus with respect to the endometrium, myometrium, symptoms, and associated pathology

A study of the uterine walls, ovaries, and endometria in a series of 100 patients having fibromyomas with a correlation between these findings and the clinical histories and symptoms, still gives us no definite basis upon which to make an absolute statement as to a single etiologic or stimulating factor in the production of fibromyomata uteri, adenomyosis externa or interna, and hyperplasia of the endometrium with resultant menorrhagia, dysmenorrhea, or sterility.Evidence in favor of Witherspoon's theory making hyperestrinism the single activator in the production of these pathologic and clinical entities, can be found in the observation of the rapid growth of fibromyomas during pregnancy and their puerperal and menopausal regression. Such facts follow very closely the estrin levels now well established, as does the discovery of hyperplasia of the endometrium associated with the presence of theca and granulosa cell tumors of the ovary in women who have passed the menopause.We have presented in our discussion factors that may tend to oppose this theory, at least in part. We must, therefore, feel with Witherspoon that hyperestrinism plays a part in the production of the changes herein studied and discussed, but we cannot be convinced that it is the sole agent because of the lack of consistency in the finding of other pathologic and symptomatologic entities in association with fibromyomas.The logical conclusion that can be derived from this study is that fibromyomata uteri, endometriosis, adenomyosis uteri, and hyperplasia of the endometrium with associated menorrhagia, dysmenorrhea, and sterility cannot be traced to a single etiologic agent but appear to be products of various and varying factors.

18. Theca cell tumors: Dr. Samuel H. Geist, New York, N. Y. (For original article, see page 480, October issue.)

18. Theca cell tumors: Dr. Samuel H. Geist, New York, N. Y. (For original article, see page 480, October issue.)

Theca cell tumors of the ovary

Certain ovarian tumors exert hormonal effects, and of the feminizing type there are two, the granulosa cell tumors and the theca cell tumors. Theca cell tumors have only recently been recognized. Two such cases are reported. They produced hyperplasia of the myometrium and endometrium, and postclimacteric bleeding. In one case the bleeding was periodic, resembling the normal menstrual cycle. The tumors are composed of cells which have the histologic characteristics of theca interna cells. Apparently these tumors secreted theelin. This conclusion is supported by much experimental and deductive evidence from the literature that the theca cells secrete the estrogenic hormone.Unfortunately, the tumors were formalin fixed before implantation experiments could be made, and no blood or urine tests for hormone were made, but perhaps future investigators may be able to do this, for diagnosis as well as for investigation. In this connection we reiterate an admonition made in a previous communication,37 namely, if in a woman past the menopause who is bleeding, nothing of an etiologic nature is found in the systemic or local examination, and curettage proves barren, one should perform a colpotomy and visualize the ovaries, in order that guilty ovarian tumors be not overlooked.