Thallium Redistribution Research Articles

Effects of diphenylthiocarbazone and diethyldithiocarbamate on the excretion of thallium by rats

The effect of diphenylthiocarbazone and diethyldithiocarbamate on the excretion and distribution of thallium in rats was determined. Diphenylthiocarbazone-treated rats excreted a greater amount of thallium than control rats, the increased excretion being primarily in the feces. Diethyldithiocarbamate also enhanced the excretion of thallium, but here the effect involved the urinary and fecal routes about equally. The drugs were approximately equipotent at the dosages at which the comparison was made. That dosage represented a maximal response for diethyldithiocarbamate. Internal redistribution of thallium is not marked as a result of treatment. Diphenylthiocarbazone mobilized thallium from all organs to approximately the same degree.