Adult Thalamus Research Articles

Intracytoplasmic neuronal inclusions in the human thalamus. Light-microscopic, histochemical, and ultrastructural observations.

Intracytoplasmic eosinophilic inclusions were found by light microscopy in the thalamic neurons of 35 consecutive normal adult brains and in a case of myotonic dystrophy, but not in six newborn children, including one with myotonic dystrophy. Histochemical tests suggested a protein composition. Ultrastructurally, the inclusions were composed of stacks of parallel alternating dark and light rectilinear profiles not surrounded by a limiting membrane. Such inclusions are a virtually constant finding in the adult human thalamus and probably represent sites of neuronal protein storage.

Mercury levels in human brain, skeletal muscle and body fluids

Neutron activation analysis was employed to quantitate the levels of mercury (Hg) in human tissue and body fluids. Statistical analysis revealed: 1. a. No significant differences (P > .05) in Hg levels among the members of each of the following groupings: (i) adult (15–91 years) and sub-adult (neonate through 14 years) frontal and cerebellar cortex, medulla, pons, midbrain, and adult thalamus. (ii) sub-adult thalamus, adult and sub-adult callosal white matter and angular and supramarginal gyri. (iii) the RBCs, plasma and urine obtained from apparently healthy volunteers. Also, there was no correlation among the Hg levels of the RBCs, plasma and urine of any single individual. 2. b. A significantly higher (P < .001) Hg level in the tissues listed in a.i. above compared to the tissues/ body fluids of a.ii and a.iii. 3. c. A significantly higher (P < .001) Hg level in the tissues listed in a.ii compared to the tissues/body fluids of a.iii. 4. d. A significantly higher Hg level in the adult gastrocnemius muscle and corpus striatum compared to the tissue/body fluids listed in a.ii (P < .01) and a.iii (P < .001); but a significantly lower Hg level (P < .01) in muscle and striatum compared to the tissues listed in a.i. 5. e. A significant positive effect of age on thalamic Hg levels (adult > sub-adult: P < .001); but, in general, no influence of age, weight, height, sex, race, national origin, occupation, regligion, cause of death and tissue handling parameters on Hg levels.

Human thalamus; an anatomical, developmental and pathological study. I. Division of the human adult thalamus into nuclei by use of the cyto-myelo-architectonic method.

Human thalamus; an anatomical, developmental and pathological study. I. Division of the human adult thalamus into nuclei by use of the cyto-myelo-architectonic method.