Thailand National Health Research Articles

Epidemiology, Seasonal Variability, and Factors Associated with Increased Mortality in Patients with Acute Appendicitis in Thailand: A Study Using Data from the National Health Security Office

Objective: The study aimed to study the spatiotemporal distribution of acute appendicitis in Thailand, using a reimbursement dataset from the National Health Security Office, and also analyze for mortality and factors associated with mortality after an appendectomy.Material and Methods: The study used data mining to analyze a reimbursement data set from the Thailand National Health Security Office (NHSO), focusing on the diagnosis of acute appendicitis (K35.2-K35.9). The analysis looked for the incidence trend and seasonal variation of the incidence. The study also analyzed mortality and factors associated with the mortality. A prediction model for mortality was constructed using a decision tree. Results: During the 4 fiscal years of the study period, from October 2016 - September 2020, a total of 287,449 individuals were diagnosed with acute appendicitis, and 272,850 appendectomies were performed, which gave an annual incidence (AI) of 10.8/10,000 person-years. The peak age incidence was in the second decade of life, which had an age-specific AI of 28.4/10,000 person-years. Using a multiplicative model of time series detrending and a decomposition model and a seasonal variation of acute appendicitis, with the highest incidence from May to October, linear regression showed a significant correlation between the incidence of appendicitis and precipitation (r2=0.28, p-value<0.001). The AI of appendicitis was declining and showed an especially large decline in the year 2020, when the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic began. The overall mortality was 2.3%. A significantly higher mortality rate was found in cases with extreme age (pediatric or geriatric), those with co-morbidities (diabetes, hypertension, dyslipidemia, chronic pulmonary disease, chronic kidney disease), and those with complications, especially generalized peritonitis, sepsis, and acute kidney injury. A decision-tree prediction model suggested that sepsis and renal complication were key nodes determining mortality risk in pediatric and geriatric appendicitis. Conclusion: A mortality risk from appendicitis remains in Thai patients, especially the elderly with co-morbidities and those with generalized peritonitis, sepsis, or renal complications. Early diagnosis and improvement in perioperative care in the extreme age groups might improve the mortality figure.

Prevalence of osteoporosis, sarcopenia, and high falls risk in healthy community-dwelling Thai older adults: a nationwide cross-sectional study.

Thailand has transitioned from an aging society to an aged society, which implies that the prevalence of age-related disorders will increase; however, epidemiological data specific to the prevalence of age-related degenerative musculoskeletal disorders among Thai older adults remain limited. Accordingly, the aim of this study was to investigate the prevalence of age-related musculoskeletal diseases, including osteoporosis, sarcopenia, and high falls risk among healthy community-dwelling Thai older adults. This cross-sectional nationwide study enrolled Thai adults aged ≥60yr from 2 randomly selected provinces from each of the 6 regions of Thailand via stratified multistage sampling during March 2021 to August 2022. All enrolled participants were evaluated for BMD, skeletal muscle mass, grip strength, and gait speed. Osteoporosis was diagnosed according to the World Health Organization definition, and sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Falls risk was determined using the self-rated Fall Risk Questionnaire. A total of 2991 eligible participants were recruited. The mean age of participants was 69.2 ± 6.5yr (range: 60-107), and 63.1% were female. The prevalence of osteoporosis, sarcopenia, and high falls risk was 29.7%, 18.1%, and 38.5%, respectively. Approximately one-fifth of subjects (19.1%) had at least 2 of 3 risk factors (ie, osteoporosis, sarcopenia, and high falls risk) for sustaining a fragility fracture, and 3.4% had all 3 risk factors. In conclusion, the results of this study revealed a high and increasing prevalence of osteoporosis, sarcopenia, and high falls risk in healthy community-dwelling Thai older adults. Since these conditions are all major risk factors for fragility fracture, modification of Thailand's national health care policy is urgently needed to address the increasing prevalence of these conditions among healthy community-dwelling older adults living in Thailand.

Procedural fairness inbenefit package design: inclusion ofpre-exposure prophylaxis ofHIV inUniversal Coverage Scheme inThailand.

Since 2002, Thailand's Universal Coverage Scheme (UCS) has adopted a comprehensive benefits package with few exclusions. A positive-list approach has gradually been applied, with pre-exposure prophylaxis (PrEP) of HIV recently being included. Disagreements resulting from competing values and diverging interests necessitate an emphasis on procedural fairness when making any decisions. This qualitative study analyses agenda setting, policy formulation and early implementation of PrEP from a procedural fairness lens. Literature reviews and in-depth interviews with 13 key stakeholders involved in PrEP policy processes were conducted. Civil society organizations (CSOs) and academia piloted PrEP service models and co-produced evidence on programmatic feasibility and outcomes. Through a broad stakeholder representation process, the Department of Disease Control proposed PrEP for inclusion in UCS benefits package in 2017. PrEP was shown to be cost-effective and affordable through rigorous health technology assessment, peer review, use of up-to-date evidence and safe-guards against conflicts of interest. In 2021, Thailand's National Health Security Board decided to include PrEP as a prevention and promotion package, free of charge, for the populations at risk. Favourable conditions for procedural fairness were created by Thailand's legislative provisions that enable responsive governance, notably inclusiveness, transparency, safeguarding public interest and accountable budgetallocations; longstanding institutional capacity to generate local evidence; and implementation capacity for realisation of procedural fairness criteria. Multiple stakeholders including CSOs, academia and the government deliberated in the policy process through working groups and sub-committees. However, a key lesson from Thailand's deliberative process concerns a possible 'over interpretation' of conflicts of interest, intended to promote impartial decision-making, which inadvertently limited the voices of key populations represented in the decision processes. Finally, this case study underscores the value of examining the full policy cycle when assessing procedural fairness, since some stages of the process may be more amenable to certain procedural criteria than others.

Factors affecting completeness of anaesthetic record: a cross-sectional study.

Anaesthesia Information Management Systems (AIMS) are of critical importance for ensuring the comprehensive recording of anaesthesia data. This study aimed to investigate the factors influencing the completeness of anaesthetic records created by various healthcare professionals including anesthesiologists, nurse anaesthetists, residents/fellows, and anaesthetic nurse trainees. Employing an online Google Forms questionnaire, this descriptive research focused on understanding the factors contributing to the completeness of anaesthetic records. The survey was distributed to all anaesthesia personnel in the department, comprising a total of 165 participants. The questionnaire encompassed three primary aspects:(1) personal information, (2) knowledge related to recording anaesthetic records, and (3) concerns related to achieving high-quality record-keeping. To assess completeness, anaesthetic record forms were evaluated based on the 2020 Medical Record Audit Guideline of Thailand's National Health Security Office, with a completeness rate exceeding 80% deemed acceptable. Spearman's rank correlation was employed to analyze the connections between the associated factors and completeness of anaesthetic records. From August to October 2021, 165 records were examined, indicating a completeness rate of 89.7%. Several factors exhibited significant correlations with the completeness of anaesthetic records. These included age (r = -0.223; P=0.004), job position (r = 0.44; P<0.001), years of anaesthesia experience (r = -0.208; P=0.007), experience in anaesthetic record training/teaching (r = 0.181; P=0.02), and attitude emphasizing high-quality record-keeping (r = 0.167; P=0.032). While personal attributes emerged as pivotal factors influencing record completeness, continuous training and a collaborative attitude were identified as critical for maintaining sustainability and achieving record-keeping goals.

The impact of rotavirus vaccination on acute diarrhea in Thai children under 5 years of age in the first year of universal implementation of rotavirus vaccines in the National Immunization Program (NIP) in Thailand: a 6-year analysis

BackgroundTwo types of rotavirus vaccines (RVs), Rotarix (RV1) and RotaTeq (RV5), were licensed as optional vaccines in 2012 and became part of the National Immunization Program (NIP) in the fiscal year 2020 in Thailand. The main objective was to evaluate the impact of rotavirus vaccines on the burden of acute diarrheal severity ranging from outpatient visits, diarrheal-related admission or deaths in the pre-NIP period (fiscal year 2015–2019) and in the fiscal year 2020. The minor objectives were assessed on the monthly admission rate, rotavirus vaccine coverage rate and rotavirus vaccine completed dose (RotaC).MethodsData regarding OPD, admission, and death cases under the Thailand National Health Coverage (NHC) from fiscal year 2015–2020, which were recorded as International Classification of Diseases and Related Health Problem 10th (ICD-10), were analyzed.ResultsThe burden of diarrheal-related disease diminished after the rotavirus vaccine was introduced in the fiscal year 2020 when compared to the previous 5 fiscal years.The OPD visit rate decreased from 10.1 to 8.3 visits per 100 person-years (P < 0.001), or a 17.8% reduction (incidence rate ratio (IRR) = 0.82; 95% confidence interval (CI): 0.81 to 0.82). The admission rate significantly declined from 31.4 to 30.5 cases per 1,000 person-years, (P < 0.001), or a 2.9% reduction (IRR = 0.97; 95% CI: 0.96 to 0.98). The diarrheal-related mortality rate also subsided from 10.2 to 8.1 cases per 100,000 person-years (P 0.3), or a 20.0% reduction (IRR = 0.88; 95% CI: 0.50 to 1.22). The major population in both admissions and deaths was infants under 1 year of age (P < 0.001). Seasonality was seen as a constant bimodal pattern, with a significant decrease in monthly admissions after 6 months of rotavirus vaccine introduction to NIP (P < 0.001). RotaC was 37.4% in the first year of NIP.ConclusionsThe rotavirus vaccine had a potential benefit for reducing the diarrheal disease burden, especially in infants under one year of age. Seasonality outbreaks of acute diarrhea subsided after the rotavirus vaccine was introduced. The RotaC was fairly low in the first year of the NIP. The quality of the rotavirus vaccine should be warranted.Trial registrationNumber TCTR20220120003, date of registration: 20/01/2022, site: Thai Clinical Trials Registry.

Association between electronic cigarette use and depression among Thai adolescents: The Thailand National Health Examination Survey 2019-2020.

Depression and e-cigarette use among adolescents are two health burdens. However, the association between these dual problems have been less studied, especially in low- and middle-income countries. This study examined the association between depression and e-cigarette use among adolescents in Thailand. This cross-sectional study used the sub-sample of the sixth Thai National Health Examination Survey conducted between 2019 and 2020. A total of 4237 adolescents aged 10-19 years were included. Self-reported depression was captured using the 20-item Centre for Epidemiologic Studies Depression Scale (CES-D). We applied a complex survey multiple logistic regression to assess whether e-cigarette use was associated with depression. The mean age of the participants was 14.6 years, 5.3% were ever e-cigarette users, and 2.9% were current e-cigarette users. 37.8% of the participants were categorized at risk for depression. Among e-cigarette users, 51.6% of ever e-cigarette users and 52.9% of current e-cigarette users were at risk for depression. Multiple logistic regression revealed that ever e-cigarette users were at higher risk for depression (AOR=1.66; 95% CI: 1.02-2.71; p=0.042) than never e-cigarette users. Current e-cigarette was not associated with a higher risk for depression (AOR=1.37; 95% CI: 0.77-2.45; p=0.263). E-cigarette use and depression among adolescents are global public health concerns. There is also a need for effective screening, prevention, and intervention to reduce adverse outcomes of e-cigarette use and depression. In addition, the government should strengthen current policies and close legal loopholes to prevent the tobacco industry tactics and keep e-cigarettes away from adolescents.

Using real world evidence to generate cost-effectiveness analysis of fibrinolytic therapy in patients with ST-segment elevation myocardial infarction in Thailand

SummaryBackgroundDue to limited access to primary percutaneous coronary intervention for the management of ST-segment elevation myocardial infarction (STEMI) in low-to-middle-income countries (LMICs), fibrinolysis serves as a vital alternative reperfusion therapy. Among fibrinolytic agents, the cost-effectiveness of tenecteplase (TNK) in LMICs as compared to streptokinase (SK) for STEMI management remains unknown.MethodsCost-effectiveness was analyzed using a hybrid model consisting of short-term analysis (30-days decision tree model) and long-term analysis (Markov model). Both health care provider and societal perspectives over a lifetime horizon with 3% discount rate were considered. Input parameters were obtained from Thailand's national health database, a network meta-analysis and literature review. Outcome measure was an incremental cost-effectiveness ratio (ICER) determined by an incremental cost per quality-adjusted life years (QALY) gain. An ICER of less than $5,590 per QALY gain is considered cost-effective. Series of sensitivity analyses were also performed.FindingsFrom the societal perspective, TNK increases cost by $827 and increases QALY by 0·173. Thus, the ICER is $4,777 per QALY gained. Similarly, the ICER from health care provider perspective is $4,664 per QALY gained. In the probabilistic sensitivity analysis, using 5,590 USD per QALY as threshold, the probability of TNK being cost-effective was 83% from both perspectives. The most influential parameters were risk ratio of death for treatment with TNK compared to SK and drug cost of TNK.InterpretationIn a resource-limited country like Thailand, tenecteplase is a cost-effective fibrinolytic drug for treatment of STEMI compared to streptokinase.FundingNone.

Burden and pattern of acute diarrhea in Thai children under 5 years of age: a 5-year descriptive analysis based on Thailand National Health Coverage (NHC) data

BackgroundThe incidence of acute diarrhea in Thai children under five years of age has increased over the last three decades. Even though mortality has significantly declined, the burden and cost of medical treatment are still high. Our objectives are to describe the burden and pattern of acute diarrhea cases that required admissions by Thai children under five years of age from 2015 to 2019.MethodsData regarding the admission of acute diarrhea cases of Thai children with Thailand National Health Coverage (NHC) under five years of age from 2015 to 2019, recorded as International Statistical Classification of Diseases and Related Health Problems, tenth Revision, Thai Modification (ICD-10-TM), were analyzed.ResultsThe incidence trend of yearly acute diarrhea in children 0–5 years of age slightly increased from 33.36 cases per 1,000 population in 2010 to an average of 33.79 cases per 1,000 population/ year from 2015 to 2019 or approximately 0.43 cases per 1,000 population over the last decade while diarrhea-related mortality had a low, constant rate of 0.71 to 1.16 per 100,000 population per year. Two thirds of the mortality rate was observed in children under 1 year of age or 4.1 cases per 100,000 person-years in 5-year period (P < 0.01). The high cost of performing the medical treatment of approximately four hundred million baht per year. Seasonal variations demonstrated consistency with similar patterns during the cold and rainy seasons throughout the 5-year period. Regional distribution of the causative agent was also observed in Cholera, Typhoid, and Amoebiasis cases. A08: viral and other specified intestinal infections and A09: other gastroenteritis and colitis of infectious and unspecified origin were the two most common causes of diarrheal diseases.ConclusionsThe incidence rate of acute diarrhea in Thai children under five years of age was higher while the mortality rate of acute diarrhea was lower than those in the past decade. A similar seasonal outbreak of acute diarrhea was seen during each examined year. The causative agent was not significant and was mainly unspecific.Trial registrationNumber TCTR20220117002, date of registration: 17/01/2022, site: Thai Clinical Trials Registry, URL http://www.thaiclinicaltrials.org/show/TCTR20220117002

Thai Universal Health Care Coverage scheme promotes the accessibility to cleft lip/palate treatment: the result of cleft care provision assessment using modified Geographic Information System

BackgroundThis study assessed the cleft lip/palate (CL/P) healthcare provision using data from the Thailand National Health Security Office from fiscal years 2012–2016.MethodsFour national databases of Thailand comprising 1) admitted patient visit, 2) non-admitted patient visit, 3) birth defects registry and 4) civil registration databases were analyzed. All duplicate records were removed by a matching process using national identity number and date of birth prior to data extraction. Modified Geographic Information System was also used to compare each provincial patients with CL/P of Thailand to the number of provincial live births with CL/P.ResultsThe results showed that the number of live births with CL/P during this period was 7,775 cases (1,555 cases/fiscal year). While the number of cases with CL/P registered under the Universal Health Care Coverage with hospital stay was 6,715 (86.37%), 927 cases (11.92%) visited hospitals without a stay, and the remaining 133 cases (1.71%) never visited any hospital. Modified Geographic Information System result showed that the provincial CL/P healthcare was relatively well-balanced with the provincial live births with CL/P (r = 0.92, p < 0.05). Moreover, provinces with CL/P tertiary care centers attracted more patients from the surrounding provinces.ConclusionThis study showed that the percentage of patients with CL/P receiving hospital treatment was 98. The Thai Universal Health Care Coverage scheme has promoted the accessibility to CL/P treatment. In order to achieve the best possible comprehensive cleft care coverage, periodical assessment and improvement of the function and accuracy of the national database registry are recommended.

Combined quality of life and survival for estimation of long-term health outcome of patients with stroke

BackgroundAdvanced medical technologies can prolong life of stroke survivors. Dynamic change of health outcomes provides essential information to manage stroke. Mathematical models, to extrapolate health status over a lifetime from cross-sectional data, can be used to investigate long term health outcomes among stroke survivors. This study aimed to estimate the health outcomes of ischemic stroke (IS) and intracerebral hemorrhage (ICH) at each survival time point.MethodsThe cohort of 5391 patients with IS and ICH stroke, registered at Ramathibodi Hospital from 2005 to 2013, were followed up regarding survival status until 2016 with the National Mortality Registry. Survival functions were extrapolated over 50 years to age- and sex-matched referents simulated from the national data of the Thailand National Health Statistic Office. From July to December 2016, the EuroQoL 5-dimension questionnaire was used to measure quality of life (QoL) among 300 consecutive, cross-sectional subsamples. The survival functions were then adjusted by the utility values of QoL for the stroke cohort to estimate quality adjusted life expectancy (QALE).ResultsThe average health utility values were lower in the initial months, then slowly increased to stable levels. However, male stroke survivors presented higher health utility than females. Throughout lifetime estimation, patients with IS stroke exhibit better health outcomes than those with ICH [10.27 vs. 7.74 quality-adjusted life years (QALYs)]. Patients with ICH presented a significantly decreased QoL than patients with IS (16.15 and 8.41 QALYs).ConclusionPreventing stroke can save people from reduced years and QoL, which can be quantified by loss-of-QALE in QALY units to compare health benefits from prevention, clinical diagnosis and direct treatment.

Registry-Based Study of Prevalence of Cleft Lip/Palate in Thailand from 2012 to 2015.

Two main objectives were established. First objective was to determine the prevalence of the cleft lip and/or cleft palate (CL/P) in Thailand from 2012 to 2015 using the orofacial clefts (OFCs) registry and civil registration. Second objective was to conduct a quality control of this OFC registry especially for the Birth Defects Registration (BDR). Registry-based survey. Analyzing data from the Thailand National Health Security Office. Registered patients with CL/P in Thailand from 2012 to 2015. None. Duplicated records were verified using National Identity Number (Thai ID#) and date of birth. The prevalence of CL/P and specific phenotypes was then calculated. From this prevalence estimate method, quality assurance of the OFCs registry was possible. For the main outcome, the population-weighted pool prevalence of CL/P was 2.14 per 1000 live births (95% confidence interval of 2.08-2.20). Thai ID# and expense reimbursement systems were the main factors driving this cases capturing. However, this OFCs registration still requires active case finding with clinical verification, improvement of staff training and databases networking. This study reported a very high CL/P prevalence of Thailand. Strengths and limitations of these OFCs registry and BDR were described.

Performance of Thailand's universal health coverage scheme: Evaluating the effectiveness of annual public hearings.

BackgroundLegislative provisions in Thailand's National Health Security Act 2002 mandate annual public hearings for providers, beneficiaries and other stakeholders in order to improve the performance of the Universal Health Coverage Scheme (UCS).ObjectiveThis study aims to explore the annual public hearing process, evaluate its effectiveness and propose recommendations for improvement.MethodIn‐depth interviews were conducted with 29 key informants from various stakeholder groups involved in annual public hearings.ResultsThe evaluation showed that the public hearings fully met the criteria of influence over policy decision and partially met the criteria of appropriate participation approach and social learning. However, there are rooms for improvement on public hearing's inclusiveness and representativeness of participants, adequacy of information and transparency.ConclusionsThree recommendations were proposed a) informing stakeholders in advance of the agenda and hearing process to enable their active participation; b) identifying experienced facilitators to navigate the discussions across stakeholders with different or conflicting interests, in order to reach consensus and prioritize recommendations; and c) communicating policy and management responses as a result of public hearings to all stakeholders in a timely manner.

Epidemiological Situation of Necrotizing Fasciitis and Factors in Thailand and Factors Associated with Its Morbidity and Mortality, 2014-2018.

IntroductionNecrotizing fasciitis (NF) is a rare skin and soft-tissue bacterial infection with high morbidity and mortality. Knowledge about the prevalence and incidence of NF in Thailand is quite sparse. The objective of this study was to determine the prevalence of NF in Thailand and factors that may be potentially associated with NF morbidity and mortality.MethodsA cross-sectional study using secondary data from Thailand’s national health databases between 2014 and 2018 was conducted. Descriptive statistics using median and percentage formats were used. This was complemented by multivariable logistic regression to determine the association between various factors (such as age and underlying diseases) with NF morbidity and mortality. Univariate spatial data analysis was exercised to identify the geographical hot spots in which the disease appeared.ResultsDuring 2014–2018, we found 90,683 NF cases. About 4.86% of the cases died. The median age for all cases was 59.39 years old. The annual incidence of NF demonstrated an upward trend (from 26.08 per 100,000 population in 2014 to 32.64 per 100,000 population in 2018). The monthly incidence was highest between May and August. A high incidence cluster (as indicated by local Moran’s I) was found in the north-eastern region of Thailand. The most infected sites were on the ankles and feet (43.18%) with an amputation rate of 7.99% in all cases. Multivariable logistic regression indicated that the significant risk factor for amputation was a presence of underlying diseases, namely diabetes (OR 7.94, 95% CI 7.34–8.61). Risk factors for mortality included being elderly (OR 1.82, 95% CI 1.68–1.98) and a presence of underlying hypertension (OR 1.16, 95% CI 1.07–1.27), cirrhosis (OR 4.67, 95% CI 4.17–5.21), and malignancy (OR 1.88, 95% CI 1.55–2.26).Discussion and ConclusionAs the elderly and those with chronic underlying diseases are likely to face non-preferable health outcomes from NF, healthcare providers should pay great attention to these groups of patients. Early and intensive treatment might be considered in these groups of patients. Further studies that aim to validate the volume of actual NF cases and reported NF cases are recommended.

Give the community the tools and they will help finish the job: key population-led health services for ending AIDS in Thailand.

Give the community the tools and they will help finish the job: key population-led health services for ending AIDS in Thailand.

Population Engagement and Consultation at the Local Level: Thailand Experience.

The World Health Organization handbook on Strategizing National Health in the 21st Century has emphasized the importance of the process of population consultation on needs and expectations. According to Thailand National Health Act 2007, three innovative social tools for participatory healthy public policy process were proposed, i.e., health assembly, health impact assessment and health system statute (charter). In practice, population consultation process is required in the process of the tools implementation. Therefore, this paper aims to illustrate how local health statute implementation supports population participation and consultation at the local level. The first local health statute owned by Cha-lae sub-district in Songkla Province had been introduced in 2009. So far, there are above 500 sub-districts or "Tambon" having their own health system statutes. Tambon Administrative Organization (TAO), health and non-health sectors, community leaders and civil society seemed to be key actors or a mechanism for the local health statute. This demonstrated three crucial elements or sectors for policy development, i.e., policy maker, evidence support and society. Contents of the local health statute are wide ranged, including social determinants, risks and diseases, life style, health services, health fund, to mental and social health in regard to the local problem and context. Therefore, it needs the process of discussion and consultation to seek their common interest and expectation. Local health statute in Thailand is an example of engagement and consultation of the population for health policy. This confirmed the process of population consultation on their needs and expectation that can be implemented both at national and local levels. This is also the strategy to improve the accountability of policy makers for health impacts at all levels of policy making. The challenges of local health statute include the mechanism to maintain and ensure the engagement and ownership for sustainable implementation. Lastly, the local government's continued commitment toward providing funding support through the implementation process and the self-assessment framework of implementation is needed.

Thailand's health ambitions pay off.

Q: Thailand has a long tradition of investing in health, why? A: Over the last decades, we have built and maintained leadership among health professionals with a strong sense of commitment. At medical and health schools in our country, we learn the teachings of Prince Mahidol. His Royal Highness, the father of our King, is considered the father of modern medicine and health in He taught us to interests first and self-interest second. He said: don't want you to be only a doctor, I also want you to be a man. Health professionals learn his teachings by heart. Every seven years we have a national medical education conference and in 1982 it adopted a resolution that medical gradates should be four things: skilled clinicians so that they can more or less alone in rural hospitals; good teachers as they must train community health workers and volunteers; good managers as they must manage district hospitals; and good supporters of primary health care. Q: Thailand is one of the first developing countries to make major progress towards universal health coverage. Why did it pursue this goal in the midst of economic crises? A: The drive towards universal health coverage came hand-in-hand with democracy. After the student revolt against the military government in 1973 and our first democratic elections in 1975, the new government made health services available free of charge to the poor. We then started to improve health insurance coverage for people with low-incomes, the formally employed, children and the elderly. It took us from 1975 to the year 2000, to move from zero to 71% of the population covered by health insurance. Then, in the 2000 election, one of the parties promised to move from 71% to 100%--full coverage--if elected. Within a year of their victory, we closed the 29% gap and on 1 January 2002 the whole population was covered. This was largely thanks to the late Dr Sanguan Nitayaramphong, the first secretary-general of Thailand's National Health Security Office, who worked tirelessly to persuade politicians and the to embrace universal health coverage. He is considered the Father of universal health coverage in Thailand. Q: How did Thailand achieve 71 % coverage in spite of the financial crises of the 1980s and 1990s? A: When the government started to provide free health care to the poor in 1975, we soon found that service access was poor because there weren't enough rural health facilities. In the spirit of the times--of primary health care and health for all--our government started to construct more district hospitals in rural areas. In 1981, annual GDP was about US$ 390 per capita, we were a low-income country facing economic downturn. We had to negotiate an International Monetary Fund loan and had a zero growth budget for five years. Despite this, our government took the courageous decision to continue expanding the rural health infrastructure. Q: How? A: The government froze all new capital investment in urban hospitals from 1982 to 1986 and invested these funds in building rural district hospitals and health centres as well as mass training and employment of doctors and community health workers. Before this, the health ministry budget for these districts was lower than in urban provinces. After 1982, it was higher, and this trend continues today. We established a compulsory public work placement of three years for medical graduates and four years for nursing graduates. We strengthened primary health care by recruiting and training volunteers in villages across the country. Today, we have about one million volunteers. So our government put us on the path to universal health coverage by investing in the rural health infrastructure. Q: Why was health policy a vote winner in the 2000 general election? A: People wanted to have access to essential health services of good quality without facing financial ruin. …

Low vegetable intake is strongly associated with venous thromboembolism in Thai population

Recent studies have demonstrated a much higher incidence of venous thromboembolism (VTE) among Asian patients compared with previous studies. This study aims to determine dietary and behavioral factors that may have contributed to this increase. A case-control study was conducted. Cases were objectively confirmed VTE between 2006 and 2009 at King Chulalongkorn Memorial Hospital. Patients with underlying cancer, antiphospholipid syndrome and arterial thrombosis were excluded. Controls were age and sex-matched healthy volunteers. Food consumption was assessed using a food frequency questionnaire modified from the Thailand National Health Examination Survey III previously validated in the Thai population. There were 97 cases and 195 controls. The mean age was 54.6 years and 70% were women. VTE patients consumed significantly less vegetable, fish and spicy food compared with normal individuals with an odds ratio (OR) for venous thrombosis of 3.74 [95% confidence interval (CI) 2.24-6.26, P < 0.001], 2.05 (95% CI 1.24-3.41, P = 0.005) and 2.30 (95% CI 1.29-4.11, P = 0.01), respectively. Additionally, thrombosis was associated with overweight (OR 2.1, 95% CI 1.21-3.62, P = 0.002), obesity (OR 3.1, 95% CI 1.46-6.74, P = 0.001) and estrogen uses (OR 3.7, 95% CI 1.05-13.2, P = 0.02), but not with smoking or lack of exercise. A multivariate analysis showed that low vegetable consumption (OR 3.74, 95% CI 1.85-7.55, P < 0.001), female hormones (OR 5.80, 95% CI 1.51-22.22, P = 0.011) and body mass index (BMI, P = 0.048) were independently associated with VTE. Low vegetable intake, hormonal use and high BMI are the risk factors for noncancer-related VTE in Thai population.

Diet, Lifestyle and Venous Thromboembolism (VTE) in Thai Population.

Abstract 1414Poster Board I-437 Introduction:Previous studies demonstrated that the incidence of venous thromboembolism (VTE) was very low among Thais (Lancet. 1975; 1: 1357-8, Arch Intern Med. 1988; 148: 1349-53). However, recent investigations in Asian countries strongly indicated that VTE is currently much more common, approaching rates in the western countries. Meanwhile, the latest National Health Surveys showed the inadequate vegetable and fruit intakes, as well as an obvious rise in prevalence of obesity in Thai population. Therefore, changing diet and behaviors are suspected to contribute to this marked increase in the VTE incidence. Patients and MethodsThe case-control study was conducted. Cases were objectively confirmed venous thromboembolism. Patients with underlying cancer, antiphospholipid syndrome and arterial thrombosis were excluded. Controls are age- and sex-matched healthy volunteers. Body mass indices, history of alcohol intake, smoking and exercise were obtained. Food consumptions were interviewed using a food frequency questionnaire modified from the Thailand National Health Examination Survey III previously validated in Thai population. Results:There were 97 cases and 195 controls. The mean age was 54.6 yr, ranging from 17-93 yr, and 70% were female. VTE was significantly associated with low vegetable intakes (below 3.5 standard servings per day) compared with controls (Odd ratio [OR] 2.5, 95% confidence interval [CI] 1.37-4.67), while there was no difference in fruit consumption (p values =0.53). Notably, low fish intakes (below 0.1 serving per day, OR 3.9, 95%CI 1.58-9.71) and having spicy food less than once a week (OR 1.9, 95%CI 1.15-3.18) also increased the risk. The meat, fat, carbohydrate, fast food or alcohol consumptions were similar. In addition, VTE was associated with overweight (OR 2.1, 95%CI 1.21-3.62) and obesity (OR 3.1, 95%CI 1.46-6.74, p values = 0.002 and 0.001, respectively). Furthermore, estrogen uses also increased the risk of VTE (OR 3.7, 95% CI 1.05-13.20, p=0.02), while smoking and lack of exercise did not. Conclusions:Low vegetable, fish and spicy food intakes, as well as obesity and hormonal uses, are the risk factors for VTE in Thai population. Disclosures:No relevant conflicts of interest to declare.

Fruit and vegetable consumption and its recommended intake associated with sociodemographic factors: Thailand National Health Examination Survey III

To examine the fruit and vegetable consumption in Thailand, the percentage of Thais meeting recommended intakes and the association with sociodemographic factors. Cross-sectional survey with a stratified, three-stage, cluster probability sampling design. Community-dwelling men and women participating in the Thailand National Health Examination Survey III. A total of 39 290 individuals aged >or=15 years were interviewed using a questionnaire to obtain information on sociodemographic characteristics and fruit and vegetable consumption. Daily fruit and vegetable consumption was estimated through the use of a short semi-qualitative FFQ. Overall, participants had average frequencies of fruit and vegetable consumption equal to 4.56 and 5.97 d/week, respectively. Average daily number of servings of fruit, vegetables and fruit plus vegetables were 1.46, 1.78 and 3.24, respectively. Intake amounts of fruit, vegetables and fruit plus vegetables varied by marital status and region, and were lower among males (except for vegetable intake), those of older age, those with low educational attainment, those with low monthly household income and those living in a rural area. Only 1/3, 1/4 and 1/4 of the population consumed the recommended >or=2, >or=3 and >or=5 servings/d for fruit, vegetables and fruit plus vegetables. Sociodemographic factors related to meeting the recommended intake of >or=5 servings/d for fruit plus vegetables included being female (OR = 1.13) and household income >or=50,000 Baht/month (OR = 1.66). The amounts of fruit and vegetables consumed by Thai participants were far below the level of current recommendations. Public education and campaigns on adequate consumption of fruits and vegetables should be targeted more towards low socio-economic groups.