TF Group Research Articles

Utilization of N-acetyl-L-tryptophan given intravenously to unrestrained adult rats.

The nutritional value of N-acetyl-L-tryptophan (NALT) given intravenously was examined in unrestrained adult rats. They were given solutions of 4% Vuj pattern amino acids, 24.5% glucose, vitamins and electrolytes intravenously for 10 days. They were divided into three groups; one group was then injected intravenously with complete amino acid solution (T group), one with tryptophan-free amino acid solution (TF group) and one group with complete amino acid solution but with NALT instead of tryptophan (NALT). The biological value of the NALT group was 49.6; this value corresponded to 90% of that of the T group. Excretion of injected amino acids totalled about 2.0 to 3.0% in this experiment. The effects of NALT on carcass composition, certain blood constituents and tryptophan pyrrolase activity in the liver were also examined.

Spatial velocity electrocardiogram of the P wave in atrial overload.

The SVECG was recorded in grand total of 119 cases with mitral stenosis in 35 cases, atrial septal defect in 51 cases, tetralogy of Fallot in 22 cases and pulmonary stenosis in 11 cases, and the correlation with hemodynamic data in 107 cases and operation findings in 78 cases was investigated. The atrial SVECG in atrial overloadings is composed of 3 types as seen in normal subjects: two-peaked, three-peaked and four-peaked patterns. In the atrial SVECG of left atrial overloading, the first peak was considered to reflect the activation of right atrium and did not increase significantly in amplitude compared with normal subjects. The spatial velocity and time interval of the third and/or fourth peaks, which were considered to reflect mainly the depolarization of the left atrium, increased significantly. The P3/P1 and P4/P1 ratios had positive correlates with the mitral valvular area ascertained at surgical operation. The atrial SVECG represents the right atrial overloading as a two-peaked pattern. Its incidence was high as in ASD group (65%) as in TF (73%) and PS (73%) groups in spite of significantly lower right ventricular systolic pressure in ASD group than in TF and PS groups (P<0.01 and P<0.01 respectively). In TF group the right ventricular systolic pressure was significantly higher in the two-peaked subgroup than in the three-peaked one (P<0.05).