Nickel matrix composites (NMCs) have received much attention as they show excellent high temperature performances, which could meet the demand for hot-end components in severe environments. In this study, the duplex in-situ nanoscale carbides and oxides reinforcing IN718 were fabricated by laser powder bed fusion (LPBF) and addition of submicron WC particles. The microstructural features and mechanical properties were investigated with variations of WC content (0, 0.5, 2, and 4 wt%). The columnar dendrites with strong <001> texture that boundary distributed continuous Laves phase were found in the LPBF-processed IN718. Incorporating WC led to higher laser absorption and processability, whereas it also decreased the anisotropy of the matrix featured by weak texture index. With an optimized content of 2 wt%, the WC was dissolved into W and C atoms under laser irradiation, which promoted the homogeneous precipitation of intergranular cubic (Nb, Ti)C (∼50 nm) and intragranular spherical Al2O3 (∼20 nm). These precipitates would for heterogenous nucleation to refine grains (∼12.6 μm) and bring about high-density dislocations. The yield strength (YS) and ultimate tensile strength (UTS) increased by 28.8% and 26.5%, respectively, while maintaining high elongation compared with reported NMCs, demonstrating a favorable strength-ductility combination. Finally, the mechanism of microstructure evolution and strengthening was elucidated.