Heterogenization of a partially β-brominated cobalt(II) tetraphenylporphyrin complex (CoIITPPBr4) within the cavities of an UiO-66 (UiO stands for Universitetet i Oslo) metal-organic framework (MOF) using bottle-around-ship (BAS) strategy resulted in the formation of highly selective recoverable biomimetic catalyst (CoIITPPBr4@UiO-66). Integrating partial β-bromination with entrapment within the MOF host improved the porphyrin complex's stability and efficiency while preventing its deactivation owing to self-destruction. Under the influence of a heterogenized catalyst with a low active component loading, the selective oxidation of thioanisole (PhSMe) to methyl phenyl sulfoxide (PhSOMe) by hydrogen peroxide (H2O2) in acetonitrile (MeCN) solvent in the presence of imidazole (ImH) co-catalyst and acetic anhydride (Ac2O) activator was expedited significantly with an outstanding conversion (96.01%) and selectivity (100%). Also, the utilization of diverse analysis techniques verified the efficacious fabrication, as well as the stability and recyclability of the catalyst after four catalytic cycles.