Tetrabromo Derivatives Research Articles

Chemistry of pongamol. Part II

Pongamol, which is the second important crystalline component of the pongamia oil, has the molecular formula C18H14O4 and contains a methoxyl group. It has also a phenolic or enolic hydroxyl group. Demethylation with aluminium chloride yields nor-pongamol whereas treatment with hydriodic acid gives rise to a product which is probably isomeric but does not possess phenolic properties. Treatment with bromine produces a tetrabromo derivative which on boiling with acetone yields a tribromo compound. Oxidation with potassium permanganate or decomposition with alkali yields benzoic acid. From these properties and from colour reactions it is suggested that pongamol is a flavone derivative containing a hydroxyl, a methoxyl and an ethylene double bond.

STUDIES ON THE EFFECT OF NUCLEIC ACID UPON THE SYNTHESIS OF OXYGEN STABLE STREPTOLYSIN BY CERTAIN STRAINS OF STREPTOCOCCUS PYOGENES

In the previous work, we ascertained the fact that the washed hemolytic streptococci, when suspended in nucleic acid solution, are able to produce streptolysin very luxuriantly.As the continuation of our research work, we recently were able to demonstrate a remarkable inhibitory effect of O: O'-dihydroxyazobenzene and its tetrabromo derivative on the streptolysin production of hemolytic streptococci.The present communication records the results of such experiments in brief.

Cholecystography: Pheniodol as a Medium for the Graham-Cole Test

The capacity of an element to absorb X rays and hence the degree of its radio-opacity depends on extra-nuclear field. The higher the atomic number of an element, i.e., the greater the number of electrons surrounding the nucleus, the greater its opacity. The contrast media now used for excretion by the kidney or liver are usually compounds of iodine, an element having an atomic number of 53. The use of a halogen compound for excretion by the liver and biliary passages to render the gall bladder opaque was introduced by Graham's Test is often used as synonymous with cholecystography, whatever chemical compound is used. They employed first the tetrachloro and later tetrabromo derivatives of phenolphthalein. Whitaker and Milliken (1924) showed that the corresponding iodine compound was superior, and since then it has been universally employed. Iodophthalein (B.P.) is the di-sodium salt of tetraiodophenolphthalein—C20H8O4I4Na22H2O. It is usually given by mouth, generally in the form of freshly precipitated tet...

Chemistry of pongamol. Part I

Pongamol, which is the second important crystalline component of the pongamia oil, has the molecular formula C18H14O4 and contains a methoxyl group. It has also a phenolic or enolic hydroxyl group. Demethylation with aluminium chloride yields nor-pongamol whereas treatment with hydriodic acid gives rise to a product which is probably isomeric but does not possess phenolic properties. Treatment with bromine produces a tetrabromo derivative which on boiling with acetone yields a tribromo compound. Oxidation with potassium permanganate or decomposition with alkali yields benzoic acid. From these properties and from colour reactions it is suggested that pongamol is a flavone derivative containing a hydroxyl, a methoxyl and an ethylene double bond.