Psychological Tests Research Articles

Spirituality, religion, and personal beliefs in Brazilian adults with epilepsy.

To evaluate the relationship between S/R, demographic data, and clinical variables of Brazilian adult patients with epilepsy (PWE). The scores of the WHO Quality of Life for Assessment of Spirituality, Religion, and Personal Beliefs (WHOQOL-SRPB) were related to demographic and clinical aspects, the Spirituality Self-Rating Scale (SSRS), and the Spiritual/Religious Coping Scale (SRC) of 60 PWE. The mean age was 42.8y and 35 (58.3%) patients reported regular religious practice. In the WHOQOL-SRPB, greater inner peace and harmony were observed in women, greater wholeness and integration, hope and optimism in married patients, and greater spiritual connection in patients with religious practice. The use of polytherapy with antiseizure medication (ASM) was associated with lower spiritual connection, wholeness, integration, and S/N in the WHOQOL-SRPB. The higher seizure frequency was associated with lower spiritual connection. Facet scores and total scores of the WHOQOL-SRPB were significantly correlated with positive and negative coping and a greater perception of spiritual guidance. In the PWE, the use of S/R differed according to gender, marital status, and religious practice. Clinical variables influenced the perception of S/R, which differed according to the use of ASM, frequency, and type of epileptic seizures. The greater use of coping and spiritual guidance was associated with different facets of S/R and personal beliefs.

Readiness for self-directed learning among undergraduate medical students in Khyber Pakhtunkhwa during COVID-19, Pakistan.

The field of medical sciences has continuously been changing and evolving rapidly pertaining to the newly introduced practices and guidelines according to the principles of evidence-based medicine. Therefore, it is of utmost importance for the healthcare practitioners to keep themselves updated and regulated through self-directed learning. A cross-sectional survey was conducted to assess the readiness of self-directed learning among undergraduate medical students. A total of 824 students participated both from public and private medical colleges of KPK. A self-reported validated SRSSDL scale was used to obtain data. The perception of public and private medical colleges students was compared and analyzedusing SPSS version 24. Differences in SDL mean scores of student groups were analyzed through independent sample t-test for groups having two categories (e.g. gender, medical college setting etc.). Mean scores of all the five academic years were compared using one-way Analysis of Variance (ANOVA). The levels of SDL readiness (e.g. good, average, poor) were cross tabulated with gender, medical college setting and academic years categories by using Chi-squaretest. the p - value was set at 0.05. The self-rated scale for SDL readiness among undergraduate medical students showed a mean score of 226.91 ± 30.074 (Minimum score = 81, Maximum score = 300) with a range of 219. On the whole, among 824 students, 61.3% of students reported good readiness for self-directed learning, 38.2% average readiness.Students enrolled in private medical colleges were more likely to report good readiness for SDL (58.4%) compared to those enrolled in public sector medical colleges (41.6%). The findings of this vast survey suggest that overall undergraduate medical students are ready for self-directed learning in their prevailing circumstances at undergraduate medical education. It also finds that students enrolled in private medical colleges are more likely to be ready for self-directed learning than those studying in public medical colleges.However, further research with qualitative analysis and longitudnal designs is recomended to explore factors promoting or preventing self directed learning.

The impact of locus of control on somatic and psychological profiles of patients with irritable bowel syndrome engaging in aerobic exercise

Irritable bowel syndrome (IBS) is a chronic and recurrent disorder characterized by gastrointestinal (GI) symptoms and psychological disorders. Individuals with an external locus of control (LoC), a personality trait influencing one’s actions and outcomes, are more vulnerable to IBS. Physical activity can deal with GI symptoms, preserving mental and physical health. In this context, our study aimed to investigate differences in symptom and psychological profiles among IBS patients classified by internal or external LoC when patients engaged in an aerobic exercise program (AEP). Each IBS patient was administered the International Physical Activity Questionnaire—Short Form (IPAQ-SF) before treatment, and the Physical Capacity Assessment Tests were applied before and after treatment. Participants filled out a GI symptom questionnaire before and after the intervention and some validated psychological tests to evaluate the changes induced by AEP. The AEP consisted of 180 min of moderate-intensity aerobic walking activity a week. Fifty-four IBS patients completed the 12-week study; 37 belonged to the internal LoC group and 17 to the external one. The internal LoC subgroup had a higher percentage of physically active subjects and a better physical capacity at baseline than those with external LoC. Only patients with an internal LoC achieved a statistically significant increase in physical capacity as the effect of the AEP. However, there was no statistically significant difference when Delta was considered. The somatic and psychological health status of IBS patients in the external LoC group was poorer than that of the internal LoC group at the baseline, particularly abdominal pain, psychosocial functioning, and emotional distress. After AEP, patients showed significant improvement in scores on the IBS-related and psychological scales, regardless of whether they belonged to the external or internal LoC. The present study confirmed the importance of considering both the GI symptoms and the psychological profile when dealing with IBS. AEP organized in walking groups has shown significant improvements for all IBS patients. Since external LoC was associated with poorer health status, individually tailored interventions should be planned to increase patients’ self-motivation to treatment.Trial registration: registration number NCT05453084. First Posted Date 12/07/2022.

Clinical value analysis of integrated care model in reducing bleeding and complications during Da Vinci robot-assisted urology.

This study aims to explore the effect of integrated care mode on patients in Da Vinci robot-assisted urology surgery and provide a new nursing scheme for clinic. A total of 93 patients from August 2022 to March 2024 were selected and divided into intervention group (43 cases) and control group (50 cases). The operation time, blood loss, first postoperative exhaust time, time to get out of bed, pain score (visual analog scale), psychological status (self-rating anxiety scale and self-rating depression scale), quality of life score (36-Item Short Form Survey), catheter retention time, patient satisfaction, incision healing, incidence of urinary system infection, nutritional status, and complication rate were compared between the 2 groups. There were no significant differences in baseline data and operative time between the 2 groups (P > .05), but the amount of intraoperative blood loss in the intervention group (250.32 ± 50.23) mL was less than that in the control group (320.56 ± 65.34) mL (P < .05). The first postoperative exhaust time and getting out of bed time in the intervention group were shorter than those in the control group (P < .05), and the pain visual analog scale score was lower than that in the control group (P < .05). The scores of self-rating anxiety scale and self-rating depression scale of mental state were better than those of the control group (P < .05), and the scores of quality of life were higher (P < .05). The retention time of catheter was shorter than that of the control group (P < .05), the patient satisfaction was 93.02% higher than that of the control group 78.00% (P < .05), and the grade A incision healing rate was 90.70% higher than that of the control group 76.00% (P < .05). The incidence of urinary system infection (4.65%) was lower than that of the control group (16.00%) (P < .05), the changes of serum albumin level and body weight were lower than that of the control group (P < .05), and the complication rate of 6.98% was lower than that of the control group (22.00%) (P < .05). Although the integrated medical care model did not significantly shorten the operation time, it was beneficial to the postoperative recovery of patients in many aspects.

Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study.

Meta-analyses of observational studies on the effect of dairy on cognitive function have yielded inconclusive results, potentially due to unmeasured confounding. To avoid the no-unmeasured confounding assumption, we used lactase persistence genetic variant as an instrumental variable, for which the CC genotype is associated with lower lactase production and, consequently, lower dairy consumption. We used it to assess the effect of long-term consumption of total and non-fermented dairy on cognitive function. We included 43,836 individuals over 55 years old with genotyping, dietary data, and cognitive function measurements from three population-based studies: CoLaus|PsyCoLaus (Switzerland), the Rotterdam Study (the Netherlands) and the Canadian Longitudinal Study on Aging (CLSA - Canada). We performed a one-sample Mendelian randomization using two-stage least-squares regression. First, we estimated total and non-fermented dairy consumption by T-allele frequency. Second, we used the estimated dairy consumption in linear regression models on general cognition, assessed by the Mini-Mental State Examination (MMSE) and the Mental Alternation Test, executive function, verbal fluency, verbal learning, and memory. Per T-allele, total dairy intake and non-fermented was 24.8 and 15.3g/day higher in PsyCoLaus, 57.9 and 49.8g/day in the Rotterdam Study, and 0.31 and 0.29 times/day in CLSA, respectively. We found no association between the genetically predicted difference and the MMSE in PsyCoLaus and the Rotterdam Study. However, lactase persistent individuals scored 3.4 (95% CI2.1- 4.7) and 3.5 (95% CI 2.3-4.7) points more in the Mental Alternation Test for total and fermented dairy, respectively, in CLSA. Similarly, lactase persistent participants in CLSA had higher verbal fluency, verbal learning and executive function, but no differences were found in the other cohorts. Such inconsistencies might stem from different FFQs across cohorts and consumption ranges. Nonetheless, the generally small magnitude of effect sizes may suggest that there is no real effect between total or non-fermented dairy intake and cognitive function. The evidence for a causal effect of dairy consumption on general cognitive function is weak, consistent with previous results from classic analysis from observational studies. Interventions targeting dairy are unlikely to have a relevant effect on cognitive function.

The efficacy of auricular acupressure combined with emotional freedom techniques on the postoperative pain and anxiety state of patients with lower limb fractures: A randomized clinical controlled trial.

Lower limb fractures cause local pain, swelling, ecchymosis, and dysfunction. Clinically, incision and reduction surgery are often employed to treat lower limb fractures. However, postoperative pain can be intense, leading to adverse emotions that hinder subsequent recovery. A total of 99 postoperative patients with lower limb fractures were randomly divided into 3 groups: the control group (routine care, 33 patients), the auricular acupressure group (routine care plus auricular acupressure, 33 patients), and the combined group (routine care, auricular acupressure, and emotional freedom techniques [EFT], 33 patients). Pain levels were measured using the visual analog scale (VAS), and anxiety levels were measured using the self-rating anxiety scale (SAS) at various time points post-intervention. Patient satisfaction with nursing care was also evaluated at the end of the intervention. The VAS scores in the combined group were significantly lower than those in the auricular acupressure and control groups at 4, 12, 24, and 48 hours post-intervention (P < .05). Additionally, the SAS scores in the combined group were significantly lower than those in the auricular acupressure and control groups at 72 hours post-intervention (P < .05). The combined group also reported significantly higher satisfaction with nursing care compared to the other 2 groups at the end of the intervention (P < .05). Auricular acupressure combined with EFT effectively reduces pain levels, alleviates anxiety, and increases patient satisfaction with nursing care in postoperative patients with lower limb fractures.

Measuring adaptive expertise and adaptive performance in (becoming) healthcare professionals: a scoping review of measurement instruments.

Professional work in healthcare is increasingly disruptive, requiring professionals to be flexible and adaptable. Research on adaptive expertise and adaptive performance in healthcare has grown, and operationalisation and measurement of these concepts are crucial to meet professionals' evolving needs. This study provides an overview of measurement instruments for adaptive expertise and adaptive performance in (becoming) healthcare professionals, including an evaluation of their operationalisations and the amount of evidence supporting their quality. A scoping review was conducted, including an analysis of operationalisations and the amount of evidence supporting the quality of instruments, based on the criteria outlined in the Standards for Educational and Psychological Testing (2014). Seventeen articles were included, comprising nineteen measurement instruments, three of which were specifically developed for the healthcare domain. The instruments, categorized into six types, varied in the nature and volume of evidence supporting their quality. Analysis of the operationalisations led to a clearer understanding of the concepts, with themes emerging around adaptive expertise and adaptive performance. The study reveals a dominance of self-evaluation and job requirement instruments, while other methods, such as design scenarios, mixed-methods instruments, and collegial verbalization, are underrepresented. Instruments developed specifically for healthcare need further validation and reliability testing. The categorization of subscales into 13 themes provides further clarification of the concepts and suggestions for future research. Instruments to measure adaptive expertise and adaptive performance are limited and vary in conceptualisation, operationalisation and quality. Further research is needed to improve the validity and reliability of healthcare-specific instruments.

Protective factors contributing to the health status of construction industry migrant workers in Chinese mainland.

Construction industry migrant workers (CIMWs) face high-intensity labor and harsh working environments, experiencing significant health issues. Studying these health issues can help to protect workers' rights, improve labor efficiency, and promote sustainable development in the construction industry. The objective of this study is to analyze the relationships among health status, social support, and marital adjustment in construction migrant workers. Data were collected from 446 migrant workers who completed the Self-rated Health Measurement Scale (SRHMS), Marital Adjustment Test (MAT), and Social Support Rating Scale (SSRS). The results showed that (1) CIMWs were in poor social health, with low social support but good marital adjustment. (2) The higher the education level and monthly income, the better the social health. (3) The scores on the SRHMS had a significant positive correlation with the scores on the MAT and SSRS, and there were significant differences in SRHMS scores among the different levels of marital adjustment. (4) Education level, subjective social support, utilization of support, and marital adjustment significantly predicted overall health status. (5) Marital adjustment directly predicted mental health and social health, and also had an indirect relationship through social support. Education level had direct and indirect predictive effects via social support on social health. Social support fully mediated the association between education level and mental health. (6) Education level, marital adjustment, and social support were all protective factors contributing to the health status of CIMWs.

Clinical characteristics and potential pathology of Moyamoya disease combined with psychiatric disorders in Chinese population - A cross-sectional study.

This study aims to identify the clinical characteristics of Moyamoya disease (MMD) combined with psychiatric disorders and explore the potential pathogenesis. Psychiatric disorders between 88 MMD patients and 72 health controls were investigated using psychological testing scales. We subsequently analyzed the clinical features of 72 MMD patients with psychiatric comorbidities retrospectively. Finally, neurotransmitters analysis was conducted to further explore the pathogenesis. Results of self-testing scales revealed a significantly higher susceptibility of psychiatric disorders in MMD patients. Compared with MMD group, clinical features of combined group demonstrated significant differences in age (51.3 ± 9.6 vs. 40.9 ± 10.4, p = 0.000), gender of female (68.1 % vs. 51.3 %, p = 0.018), duration time (33.3 ± 44.6mon vs. 8.1 ± 15.3mon, p = 0.000), cerebral infarction (55.2 % vs. 70.8 %, p = 0.025), initial type, Suzuki stage and mRS scores (p < 0.05). The perfusion results revealed significantly decreased time to peak in frontal parietal lobe (1854.14 ± 238.62 vs. 1242.79 ± 115.99, p = 0.025), temporal occipital lobe (1721.55 ± 245.15 vs. 1165.71 ± 111.55, p = 0.040), lateral ventricle (1840.03 ± 256.88 vs. 1221.95 ± 115.53, p = 0.028), and the cerebral blood volume of temporal occipital lobe was found significantly decreased (300.36 ± 34.93 vs. 403.23 ± 19.70, p = 0.026), and remarkable lower incidence of hyperperfusion syndrome and subdural effusion were demonstrated. Differential neurotransmitters of decreased 3-htdroxybutyric acid expression and increased sarcosine, tyrosine, betaine aldehyde chloride, kynurenic acid, glycine, succinic acid and lysine were identified in combined group. Patients of MMD combined with psychiatric disorders presented unique clinical characteristics. Neurotransmitters disorder may be involved in the pathogenesis. These results provided novel clinical management evidence and new insights in pathologic mechanism of MMD combined with psychiatric disorders.

Heart rate variability versus visual analog scale for objective and subjective mental fatigue detection: A randomized controlled trial

Fatigue is a multidimensional phenomenon. Although psychological tests can be used to evaluate subjective fatigue, an objective measurement of fatigue is needed to evaluate mental, physical, and occupational health and inform appropriate interventions. Heart rate variability (HRV) has emerged as a potential candidate for assessing objective mental fatigue; however, its effectiveness and safety remain inconclusive. To address these, we conducted a single-center, randomized trial to compare the efficacy and safety of HRV with subjective psychological tests for evaluating mental fatigue. Participants aged 20 to 65 years who had received annual health check-ups and had been found to have no health concerns were included in this study. We compared HRV indexes after performing a calculation task with a control group that rested. The primary outcomes were HRV indexes as recorded by wearable electrocardiography after an intervention consisting of a calculation task. Subjective measures (visual analog scale [VAS] for fatigue and Profile of Mood States 2nd Edition [POMS2]) were evaluated as secondary outcomes. One hundred forty participants were randomized into a calculation task and control groups. Participants who performed the calculation task had a lower square root of the mean squared differences between successive RR intervals (RMSSD), absolute power in the high-frequency band, and standard deviation of Poincaré plot. In psychological tests, participants who performed the calculation task demonstrated significantly higher scores on the VAS for fatigue and POMS2. Multiple comparisons of RMSSD from HRV indexes, VAS for fatigue, and total mood disturbance from POMS2 revealed that RMSSD and VAS for fatigue were significant indicators associated with the calculation task. On the other hand, the vectors of HRV indexes and psychological tests differed based on primary component analysis. We identified RMSSD, an objective index, and VAS for fatigue, a subjective index, as significantly related to mental fatigue.

Neuroanatomical Insights: Convergence and Divergence of Tinnitus with Normal or Mild Hearing Loss

Objectives: To explore the neuroanatomical abnormalities in idiopathic tinnitus patients by voxel-based morphometry (VBM) and surface-based morphometry (SBM) techniques. To elucidate the central plasticity in tinnitus patients with normal or mild hearing loss from the neuroanatomical insights. Methods: A total of 74 patients with idiopathic tinnitus (43 with normal hearing and 31 with mild hearing loss) and 98 healthy subjects were enrolled. VBM and SBM were employed to analyze neuroimaging data and identify neuroanatomical differences. Results: Our analysis revealed a reduction in gray matter volume and a distinctive pattern of changes in cortical surface features in patients with idiopathic tinnitus, especially in brain regions closely related to the limbic system, such as the bilateral parahippocampal gyrus, bilateral entorhinal cortex, and insula. Tinnitus patients with mild hearing loss have more extensive gray matter volume reduction, and more complex changes in cortical surface features compared to tinnitus patients with normal hearing. In addition, we also found a significant correlation between the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale (SDS), and Montreal Cognitive Assessment (MoCA) scores of patients with idiopathic tinnitus and cortical characteristic parameters in the above brain regions. Conclusions: There are extensive neuroanatomical alterations in tinnitus patients. Mild hearing loss may aggravate the reduction of gray matter volume and change the surface characteristics of the cortex. Anxiety, depression, and cognitive impairment in patients with idiopathic tinnitus may be related to neuroanatomical alterations in specific brain regions.

Validation of the Singing Voice Handicap Index in Greek Singers: Normal and Voice-Disordered Participants.

The Singing Voice Handicap Index (SVHI) was culturally adapted and validated in Greek to examine the impacts of voice problems on a singer's everyday life. The translated version was administered to 120 singers in total, along with the translated version of the Voice Handicap Index (VHI), a sort voice history questionnaire, two Self-Rating Dysphonia Severity Scales (SRDSSs), and two visual analog scales. A week after the original completion of the Greek version of SVHI, a second copy of the SVHI was administered to 50% of the participants. The results showed high test-retest reliability (Pearson correlation coefficient (PCC): 0.859, P=0.000) and excellent internal consistency (Cronbach's Alpha=0.960). A significant difference between healthy and voice disordered singers emerged (18.01±13.213, 43.26±20.196; K-W: P=0.000; ROC: Area=0.863, Std.= 0.041, P=0.000). Also, high concurrent (Spearman's rho 0.55, P= 0.000) and face (Spearman's rho: SRDSS1 0.481, P=0.000; SRDSS2 0.504, P =0.000) validity scores were observed. Regarding the relation of the demographic variables or habits that could relate to voice disorders, only the years of experience (PCC: -0.240, P=0.008) and singing lessons (Spearman's rho: -0.286, P=0.002) had a strong correlation with SVHI. In conclusion, the Greek version of the SVHI questionnaire was validated successfully as a reliable tool with proper internal consistency. It will serve as a suitable and valuable instrument for self-evaluation of a vocal difficulty's effects on a singer's day-to-day life.

An interventional study on the application of heart-collateral-based enlightenment words intervention in anxiety and depression of patients after percutaneous coronary intervention

ObjectiveTo study the effect of heart-collateral-based enlightenment words intervention on anxiety and depression in patients following percutaneous coronary intervention (PCI).MethodsIn this class experimental study, one hundred patients who were hospitalized after PCI from May 2020 to October 2021, were included in this interventional study. They were divided into the test group (n = 50) and the control group (n = 50) based on the random number table. The heart-collateral-based enlightenment words intervention was used in the test group versus routine nursing in the control group. Data was collected using a self-rating anxiety scale (SAS), self-rating depression scale (SDS), and an independently developed satisfaction questionnaire. Psychological indicators and satisfaction were compared between the two groups before and after the intervention.ResultsAfter 3 months of intervention, the test group scored significantly lower in SDS and SAS than the control group (SDS score: [55.06 ± 8.63] vs. [62.90 ± 9.52]; SAS score: [46.83 ± 10.24] vs. [56.02 ± 8.92]) (P < 0.05 for both SDS and SAS difference). The satisfaction rate of the test group vs. control group was 96% vs. 82% after the intervention, with a statistically significant difference (P < 0.05).ConclusionHeart-collateral-based enlightenment words intervention can effectively alleviate anxiety and depression in patients after PCI and increase their satisfaction with nursing services. To develop the theory and guide clinical practice, future research in different treatment area with larger sample size should be conducted.

Impact of care guilt on the health status of female medical staff: a cross-sectional study

BackgroundIn this study, we explored changes to female medical staff’s health status under the influence of care guilt in the process of balancing work and family care responsibilities. The mediating role of time pressure within this nexus was examined, and an ideal concept derived from the Confucian cultural context, “Zhong-yong,” was investigated as a moderator of the impact of care guilt on health status.MethodA questionnaire survey of 407 full-time female medical staff with family care needs, recruited using convenience sampling from eight hospitals in China, was conducted. The survey tools comprised the Relationship Guilt Scale, Dapkus’ time pressure scale, Zhong-yong scale, and Self-rated health status scale. A moderated mediation model was established to test the hypotheses.ResultsCare guilt had a significant negative impact on health condition after controlling for variables such as age, educational level, and professional position. Time pressure mediated the association between care guilt and health status. Zhong-yong levels moderated the effects of care guilt on time pressure and had a direct effect on health condition. Care guilt weakened health condition, partly through the experience of time pressure. However, low levels of Zhong-yong predicted a greater negative impact of care guilt on health condition.ConclusionFemale medical staff require a comprehensive approach to balancing their work and family responsibilities to mitigate their experience of guilt and poor health.

The mediating effect of self-efficacy and physical activity with the moderating effect of social support on the relationship between negative body image and depression among Chinese college students: a cross-sectional study

BackgroundFitness to maintain an ideal body shape is becoming increasingly popular among college students. However, it also leads to many mental health issues. This study explores the pathways through which negative body image affects depression in college students. It also examines possible means of implementing depression interventions in college populations through the mediating roles of self-efficacy and physical activity, and the moderating role of social support.MethodThe present study employed a convenience sampling method to collect data from 600 university students using the Body Image Scale, Self-Efficacy Scale, Physical Activity Scale, General Social Support Scale and Depression Self-Rating Scale. Data analysis and structural equation modeling were conducted using SPSS, M-plus and R software.ResultThe result indicate that negative body image is positively correlated with depression. Self-efficacy and physical exercise play a chain mediating role between body image and depression. Additionally, social support moderates the effects of self-efficacy by predicting the pathway through which physical activity effects depression.ConclusionThe study suggest that individuals with a negative body image are more prone to depression and that physical exercise can help alleviate their depressive symptoms. Self-efficacy is an important mediator, and social support moderates adherence to physical exercise. Therefore, attention should be paid to the mental health issues of college students with negative body images.

Sleep quality during pregnancy following assisted reproductive technology and natural conceiving: a prospective birth cohort study

PurposeTo investigate the association of sleep quality during pregnancy on in vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI) and natural conceiving (NC), as well as anxiety, depression, and perceived stress.MethodsThis prospective cohort study includes 500 infertile pregnant women undergoing IVF/ICSI and 678 NC women in a Sichuan birth cohort. Data on sleep, anxiety, depression, and stress was collected in the first trimester (T1), second trimester (T2), and third trimester (T3) using integrated questionnaires. Sleep quality is quantified by the Pittsburgh Sleep Quality Index (PSQI) with a cut-point of 5 indicating poor sleep. The Self-rating Anxiety Scale (SAS), the Center for Epidemiologic Study of Depression scale (CES-D), and the Perceived Stress scale (PSS) were used for assessing anxiety, depression, and perceived stress symptoms. Additionally, the matched husbands are surveyed. Multivariable logistic regression models with adjustments for influencing factors were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations of sleep quality.ResultsIn the IVF/ICSI group, 61.1%, 55.5%, and 66.5% of participants in T1, T2, and T3 reported poorer sleep quality compared to the NC group, which had 43.2%, 37.4%, and 46.4% throughout the same trimesters. Additionally, the IVF/ICSI group exhibited higher levels of negative psychological factors as measured by the CES-D and PSS during T1 and T2, showing statistical significance in T1 (P = 0.008, P &amp;lt; 0.001) and T2 (P = 0.038, P &amp;lt; 0.001), except at T3 (P = 0.107, P = 0.253). In addition to psychological factors and IVF/ICSI treatment, poor sleep quality was also associated with advanced age. However, there was no significant difference in sleep quality between the husbands of the IVF/ICSI and NC groups.ConclusionThe study reveals that women receiving IVF/ICSI treatment are at a higher risk of experiencing sleep disturbances throughout their pregnancy compared with women with natural conception. While partners typically do not report major sleep problems, they do exhibit increased anxiety levels. These findings underscore the necessity for screening and addressing sleep issues in women pregnant through assisted IVF/ICSI treatment, to promote their well-being during this critical period.

DOP008 High clinical and endoscopic remission rate with Vedolizumab in early CD patients: the 2nd interim analysis from a prospective multicenter interventional Study (EARLY CD)

Abstract Background Early treatment with advanced therapy prior to the development of complications such as stricture and fistula, is associated with better disease prognosis in patients (pts) with Crohn’s disease (CD). This study (EARLY CD) aims to evaluate the efficacy and safety of Vedolizumab (VDZ) as first line therapy in pts with early CD. Methods EARLY CD is a prospective, single-arm, multicenter, interventional study (ChiCTR2200063233). Target enrollment was 172 pts and all pts will receive up to 50 weeks of VDZ treatment with dose optimization (additional dose at week 10 if no clinical response, and switch to Q4W if secondary loss of response at maintenance). Main inclusion criteria for early CD are disease duration less than 18 months, no previous use of immunosuppressive agents and advanced treatment, no complications such as fistula or stricture (except for inactive perianal fistula). Primary endpoint was clinical and endoscopic remission at week 52, together with several secondary endpoints including clinical and endoscopic response, transmural healing assessed by MRE, and improvements in both PRO and QoL. This second interim analysis was conducted when all 172 enrollments were completed. Results 172 pts were recruited with a median follow-up of 7.1 months (IQR 3.3-11.7). Mean age was 30.9 years, 73.8% were male. Mean CDAI score at baseline was 245.97 and SES-CD score was 9.7 (table). Clinical and endoscopic remission rates reached 83.8% and 48.7% at week 14, with further increase to 92.1% and 71.1% at week 52 (figure). Early clinical improvement was observed, with both abdominal pain score (APS) and loose stool frequency score (LSFS) started to decline from week 1, APS decreased by 50.6% (from 44.9 to 22.2), LSFS decreased by 56.1% (from 32.5 to 14.26). From week 1 to week 52, IBDQ improved from 157.8 to 185.9, self-rated health status EQ visual analogue scale increased from 72.3 to 85.4, and self-reported fatigue score assessed by FACIT improved from 38.1 to 43.9. Twenty pts have completed MRE evaluation both at baseline and week 52, with MaRIA score showing a decline from 23.9 to 20.3. Adverse events occurred among 20 pts (11.6%), including exacerbation of perianal disease that required surgical drainage (n=6), arthralgia (n=4), infection (n=7), GI bleeding (n=1), acute appendicitis (n=1), and elevated transaminase (n=1). Conclusion This is the first study worldwide to prospectively evaluate the efficacy of VDZ as first-line therapy among bio-naïve pts with early CD. Interim analysis showed promising results including high clinical and endoscopic remission rates through week 52, together with early PRO response and improvement in quality of life.

Age effect analysis of different gender groups in spatial ability test based on virtual reality technology

PurposeThe objective of the present study was to examine the impact of age and cognitive autonomy across various gender categories. Moreover, this research seeks to delve into the dissociation of diverse spatial aptitude assessments, with the aim of elucidating the intricate mechanism underpinning spatial capability.MethodBased on virtual reality technology, this study conducted spatial ability tests on 312 volunteers, aged from 18 to 90 years old, including R-letter rotation test, S-M mental rotation, surface development test and maze test.ResultsThe analysis revealed that the spatial ability of men decreases with age, but the spatial ability of women between 28 and 37 years old is better than that of other age groups. Males outperformed females in most visual ability tests, but there was no significant difference in some age groups. There was no significant correlation between the R-letter rotation test and the S-M mental rotation test, and the two tests were independent. The relationship between visual ability and orientation ability is different in different spatial test indicators.ConclusionThis investigation further elucidates the dissimilarities in the age-related characteristics of spatial aptitude among diverse gender cohorts, as well as the autonomy of various spatial aptitude assessments. Such distinctions are instrumental in occupational preference for disparate groups, calling for comprehensive and meticulous inquiries into the maturation of spatial proficiency by researchers.

The Occupational Stress Questionnaire for Law Enforcement Services

Aim: Motivation is an important management tool, especially in organisations where people's skills and abilities are crucial to effective performance. An example of such an organisation is the Police, which is still people-centred despite information technology modernisation. Motivation is therefore essential not only in leadership, but also in the psychological selection process, and its components and characteristics are examined. Methodology: For each member of the law enforcement services is a must, based on the legal obligation, to have the proper health, psychic and physical condition. The psychological test can facilitate police recruit selection, which includes, among others, an Occupational Stress Questionnaire for Law Enforcement Services (OSQLES), which has been used for decades in Hungary. Findings: In according to Herzberg's two-factor theory, I review and analyse the OSQLES' relevance and suitability for law enforcement services. Value: I will answer two questions. Firstly, whether the OSQLES is a suitable method to obtain the right information through questions and scales and secondly, whether it is suitable to identify the factors of the Herzberg's theory.

The efficacy and safety of patient-controlled intravenous analgesia with esketamine after total hip arthroplasty: a randomized controlled trial

PurposeTo evaluate the efficacy and safety of esketamine-based patient-controlled intravenous analgesia following total hip arthroplasty.MethodsA total of 135 total hip arthroplasty patients were randomly assigned to one of the three treatment groups: esketamine, sufentanil or continuous fascia iliaca compartment block (FICB) group. The primary endpoint was the postoperative visual analogue scale (VAS) pain scores at rest and on movement. Secondary endpoints included preoperative 1-day and postoperative 7-day Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores, the satisfaction of patients and surgeons, postoperative 1-month and 3-month Harris function scores, the incidence of adverse reactions.ResultsAt 48 h post-surgery, the VAS pain scores in the esketamine and FICB groups at rest and on movement were significantly lower than those in the sufentanil group (P < 0.05). The satisfaction of patients in the esketamine group was higher than that in the sufentanil and FICB groups (P = 0.014). The satisfaction of surgeons in the esketamine and FICB groups was higher than that in the sufentanil group (P = 0.002). At postoperative day 7, the SAS scores and SDS scores in the esketamine group were significantly lower than those in the sufentanil and FICB groups (P < 0.05). Compared with the sufentanil group, the postoperative nausea and vomiting, dizziness and total adverse reactions in the esketamine group and FICB group were lower (P < 0.05).ConclusionPatient-controlled intravenous analgesia with esketamine has the potential to provide good postoperative analgesia for total hip arthroplasty patients, reduce the incidence of adverse reactions after the operation, improve the satisfaction of patients and surgeons, and significantly improve patients’ postoperative mood.Trial registration: ChiCTR2300069632 (https://www.chictr.org.cn/) (March 22th, 2023).