The current study offers a sustainable supply chain model that can be used to identify opportunities and constraints for the future of the microalgae-based bio-diesel and bio-plastic industry. The network’s carbon emissions are restricted by an uncertain constraint that allows for flexibility in controlling emissions as needed. The social constraints of the model provides a transparent depiction of labour needs in dynamic business landscape and foster women’s empowerment through a preference coefficient. The proposed model introduces a new upside risk measures under fuzzy-stochastic setting to quantify the upward financial risk. To characterize and manage the model uncertainty, a fuzzy-stochastic distributional robust model is presented. Credibility distribution is utilized to handle fuzzy uncertainty, while box and polyhedral uncertainty sets are included to handle stochastic uncertainty. After that, tractable deterministic formulations of the uncertain model for two ambiguity sets are presented to solve the model. Finally, a number of insights are obtained by means of five test problems that are implemented in Python and resolved by one exact and five meta-heuristic algorithms. Experiments indicate that, when faced with uncertainty, two robust models have produced more stable solutions (16.23% and 19.67% higher stability, respectively) than nominal stochastic model. Further, a 4.68% decline in total cost and 3.27% increment in bio-diesel production can be achieved by increasing bio-diesel conversion rate to 10%. In addition, a 9.09% downturn in total cost and 10.44% rise in bio-plastic production can be obtained by 10% increment in bio-plastic conversion rate. Moreover, 45.38% more woman labours can be recruited by increasing the preference coefficient from −0.2 to +0.2.