Damage to devices installed in electric substations, which have shown vulnerable behaviour under strong earthquakes in the last decades, may endanger power delivery in the emergency phases during and after an earthquake. Within seismic risk assessment of power networks, the definition of the fragility functions of electric equipment is paramount. However, in the current literature the availability of such fragility models for some specific electric substation components, including instrument transformers, is relatively limited, this being the reason behind the deployment of the current experimental and numerical research endeavour. Two voltage transformers and two current transformers having different system voltage levels (respectively in the high voltage HV and extra-high voltage EHV ranges) were subjected to shake table tests, and the experimental results were used to calibrate the corresponding 3D numerical models developed in OpenSees. A number of nonlinear dynamic analyses carried out within a multiple-stripe analysis (MSA) framework allowed the derivation of 16 fragility curves for the four transformers in both stand-alone and elevated/supported configurations, considering also two different soil types. Based on the derived curves, one of the voltage transformers is expected to experience light or negligible damage due to earthquake shaking, owing to its high resonance frequencies (and hence stiffness), whilst the remaining three devices may suffer moderate damage under medium to strong shaking intensities; however, their seismic risk is in effect mitigated by the presence of the typically employed supporting column. Comparison against models available in the literature lent valuable reassurance on the adequacy of the employed methodology and the reliability of the derived fragility curves.