Test Dataset Research Articles

Prediction of Lithium-Ion Battery Health Using GRU-BPP

Accurate prediction of lithium-ion batteries’ (LIBs) state-of-health (SOH) is crucial for the safety and maintenance of LIB-powered systems. This study addresses the variability in degradation trajectories by applying gated recurrent unit (GRU) networks alongside principal component analysis (PCA), Granger causality, and K-means clustering to analyze the relationships between operating conditions—such as temperature and load profiles—and battery performance degradation. This paper uses a publicly accessible dataset derived by aging three prismatic LIB cells under a realistic forklift operation profile. First, we identify the features that are relevant to driving variance, then we employ the winning algorithm of K-means clustering for the classification of operational states. Granger causality later investigates the inter-group relationships. Our GRU-BPP model achieves an RMSE value of 0.167 and an MAE of 0.129 for the reference performance testing (RPT) dataset and an RMSE of 0.032 with an MAE of 0.025 for the aging dataset, thus outperformed benchmark methods such as GRU, LME, and XGBoost. These results further enhance the predictiveness and robustness of this approach and yield a holistic solution to the conventional challenges in battery management and their remaining useful life (RUL) predictions.

Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology

A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained whole slide images from the largest reported cohort to date. The model showed promising performance in identifying diagnostic category, grade, mitosis-karyorrhexis index (MKI), and MYCN-amplification with validation on an external test dataset, suggesting potential for AI-assisted neuroblastoma classification.

Resolution-dependent MRI-to-CT translation for orthotopic breast cancer models using deep learning.


This study aims to investigate the feasibility of utilizing generative adversarial networks (GANs) to synthesize high-fidelity CT images from lower-resolution MR images. The goal is to reduce patient exposure to ionizing radiation while maintaining treatment accuracy and accelerating MR image acquisition. The primary focus is to determine the extent to which low-resolution MR images can be utilized to generate high-quality CT images through a systematic study of spatial resolution-dependent MRI-to-CT image conversion. 
Approach. 
Paired MRI-CT images were acquired from healthy control and tumor models, generated by injecting MDA-MB-231 and 4T1 tumor cells into the mammary fat pad of nude and BALB/c mice to ensure model diversification. To explore various MRI resolutions, we downscaled the highest-resolution MR image into three lower resolutions. Using a customized U-Net model, we automated region of interest masking for both MRI and CT modalities with precise alignment, achieved through three-dimensional affine paired MRI-CT registrations. Then our customized models, Nested U-Net Generative Adversarial Network (NUGAN) and Attention U-Net Generative Adversarial Network (AUGAN), were employed to translate low-resolution MR images into high-resolution CT images, followed by evaluation with separate testing datasets.
Main Results.
Our approach successfully generated high-quality CT images (0.142 mm²) from both lower-resolution (0.282 mm²) and higher-resolution (0.142 mm²) MR images, with no statistically significant differences between them, effectively doubling the speed of MR image acquisition. Our customized GANs successfully preserved anatomical details, addressing the typical loss issue seen in other MRI-CT translation techniques across all resolutions of MR image inputs.
 Significance. 
This study demonstrates the potential of using low-resolution MR images to generate high-quality CT images, thereby reducing radiation exposure and expediting MRI acquisition while maintaining accuracy for radiotherapy.&#xD.

Use of biomarkers of metals to improve prediction performance of cardiovascular disease mortality

BackgroundWhether including additional environmental risk factors improves cardiovascular disease (CVD) prediction is unclear. We attempted to improve CVD mortality prediction performance beyond traditional CVD risk factors by additionally using metals measured in the urine and blood and with statistical machine learning methods.MethodsOur sample included 7,085 U.S. adults aged 40 years or older from the National Health and Nutrition Examination Survey 2003–2004 through 2015–2016, linked with the National Death Index through December 31, 2019. Data were randomly split into a 50/50 training dataset used to construct CVD mortality prediction models (n = 3542) and testing dataset used as validation to assess prediction performance (n = 3543). Relative to the traditional risk factors (age, sex, race/ethnicity, smoking status, systolic blood pressure, total and high-density lipoprotein cholesterol, hypertension, and diabetes), we compared models with an additional 17 blood and urinary metal concentrations. To build the prediction models, we used Cox proportional hazards, elastic-net (ENET) penalized Cox, and random survival forest methods.Results420 participants died from CVD with 8.8 mean years of follow-up. Blood lead, cadmium, and mercury were associated (p < 0.005) with CVD mortality. Including these blood metals in a Cox model, initially containing only traditional risk factors, raised the C-index from 0.845 to 0.847. Additionally, the Net Reclassification Index showed that 23% of participants received a more accurate risk prediction. Further inclusion of urinary metals improved risk reclassification but not risk discrimination.ConclusionsIncorporating blood metals slightly improved CVD mortality risk discrimination, while blood and urinary metals enhanced risk reclassification, highlighting their potential utility in improving cardiovascular risk assessments.

DeepLigType: Predicting Ligand Types of Protein-Ligand Binding Sites Using a Deep Learning Model.

The analysis of protein-ligand binding sites plays a crucial role in the initial stages of drug discovery. Accurately predicting the ligand types that are likely to bind to protein-ligand binding sites enables more informed decision making in drug design. Our study, DeepLigType, determines protein-ligand binding sites using Fpocket and then predicts the ligand type of these pockets with the deep learning model, Convolutional Block Attention Module (CBAM) with ResNet. CBAM-ResNet has been trained to accurately predict five distinct ligand types. We classified protein-ligand binding sites into five different categories according to the type of response ligands cause when they bind to their target proteins, which are antagonist, agonist, activator, inhibitor, and others. We created a novel dataset, referred to as LigType5, from the widely recognized PDBbind and scPDB dataset for training and testing our model. While the literature mostly focuses on the specificity and characteristic analysis of protein binding sites by experimental (laboratory-based) methods, we propose a computational method with the DeepLigType architecture. DeepLigType demonstrated an accuracy of 74.30% and an AUC of 0.83 in ligand type prediction on a novel test dataset using the CBAM-ResNet deep learning model. For access to the code implementation of this research, please visit our GitHub repository at https://github.com/drorhunvural/DeepLigType.

Cone-Beam CT to CT Image Translation Using a Transformer-Based Deep Learning Model for Prostate Cancer Adaptive Radiotherapy.

Cone-beam computed tomography (CBCT) is widely utilized in image-guided radiation therapy; however, its image quality is poor compared to planning CT (pCT), thus restricting its utility for adaptive radiotherapy (ART). Our objective was to enhance CBCT image quality utilizing a transformer-based deep learning model, SwinUNETR, which we compared with a conventional convolutional neural network (CNN) model, U-net. This retrospective study involved 260 patients undergoing prostate radiotherapy, with 245 patients used for training and 15 patients reserved as an independent hold-out test dataset. Employing a CycleGAN framework, we generated synthetic CT (sCT) images from CBCT images, employing SwinUNETR and U-net as generators. We evaluated sCT image quality and assessed its dosimetric impact for photon therapy through gamma analysis and dose-volume histogram (DVH) comparisons. The mean absolute error values for the CT numbers, calculated using all voxels within the patient's body contour and taking the pCT images as a reference, were 84.07, 73.49, and 64.69 Hounsfield units for CBCT, U-net, and SwinUNETR images, respectively. Gamma analysis revealed superior agreement between the dose on the pCT images and on the SwinUNETR-based sCT plans compared to those based on U-net. DVH parameters calculated on the SwinUNETR-based sCT deviated by < 1% from those in pCT plans. Our study showed that, compared to the U-net model, SwinUNETR could proficiently generate more precise sCT images from CBCT images, facilitating more accurate dose calculations. This study demonstrates the superiority of transformer-based models over conventional CNN-based approaches for CBCT-to-CT translation, contributing to the advancement of image synthesis techniques in ART.

Optimal design of neural network-based fuzzy predictive control model for recommending educational resources in the context of information technology

Abstract As the information technology develops, educational resource recommendation system has become an indispensable part of the education field. At the same time, people’s demand for personalised educational resources is also growing; therefore, how to accurately predict user demand and provide personalised recommendations has become an important issue. In this study, a fuzzy predictive control model on the grounds of neural network is proposed to optimise the design of educational resource recommendation in the context of information technology. After experimental testing, the model recommendation fit reached 95.16 and 92.91% on the two test datasets, which are significantly higher than the control model. The average F1 values of the proposed model also reached 95.21 and 88.77%, which are higher than the control model. In other control experiments, the proposed model of this study also has a better performance. The relevant outcomes showcase that the predictive performance and recommendation effect of the model can be further enhanced by improving the structure of the neural network and the parameter optimisation method. Meanwhile, the proposed model has high performance in information overload and personalised demand, which offers a useful reference for the optimal design of educational resource recommendation system.

Deep learning-based alpha particles spectroscopy with solid-state nuclear track detector CR-39

A novel approach for alpha particles energy spectroscopy utilizing a sophisticated deep learning machine learning algorithm is introduced. The approach we employ classifies the alpha particles trajectories on a CR-39 detector into six discrete energy levels: 0.5 MeV, 1.5 MeV, 2.5 MeV, 3.5 MeV, 4.5 MeV, and 5.4 MeV. Some 57 different CR-39 detectors were exposed to alpha particles of the stated energy levels using a241Am source. The dosimeters were then subjected to etching and imaging utilizing a Landauer Neutrak© system. A self-developed computer vision method was used to separate the energy-tagged alpha tracks from the CR-39 images. These tracks images were then inputted into an artificial neural network (ANN) algorithm for training. After completing the training, a test dataset was run to assess the algorithm's performance. An average accuracy rate exceeding 98% was attained across the six energy levels.This algorithm has the potential to enhance the precision of alpha particle dosimetry. Furthermore, once generalized to a continuous energy spectrum, as well as for other types of particles such as protons, this algorithm is anticipated to prove highly beneficial for analyzing the outcomes of various laser-driven high-energy particle experiments in general, and specifically for fusion experiments.

Compare three deep learning-based artificial intelligence models for classification of calcified lumbar disc herniation: a multicenter diagnostic study

ObjectiveTo develop and validate an artificial intelligence diagnostic model for identifying calcified lumbar disc herniation based on lateral lumbar magnetic resonance imaging(MRI).MethodsDuring the period from January 2019 to March 2024, patients meeting the inclusion criteria were collected. All patients had undergone both lumbar spine MRI and computed tomography(CT) examinations, with regions of interest (ROI) clearly marked on the lumbar sagittal MRI images. The participants were then divided into separate sets for training, testing, and external validation. Ultimately, we developed a deep learning model using the ResNet-34 algorithm model and evaluated its diagnostic efficacy.ResultsA total of 1,224 eligible patients were included in this study, consisting of 610 males and 614 females, with an average age of 53.34 ± 10.61 years. Notably, the test datasets displayed an impressive classification accuracy rate of 91.67%, whereas the external validation datasets achieved a classification accuracy rate of 88.76%. Among the test datasets, the ResNet34 model outperformed other models, yielding the highest area under the curve (AUC) of 0.96 (95% CI: 0.93, 0.99). Additionally, the ResNet34 model also exhibited superior performance in the external validation datasets, exhibiting an AUC of 0.88 (95% CI: 0.80, 0.93).ConclusionIn this study, we established a deep learning model with excellent performance in identifying calcified intervertebral discs, thereby offering a valuable and efficient diagnostic tool for clinical surgeons.

BreCML: identifying breast cancer cell state in scRNA-seq via machine learning

Breast cancer is a prevalent malignancy and one of the leading causes of cancer-related mortality among women worldwide. This disease typically manifests through the abnormal proliferation and dissemination of malignant cells within breast tissue. Current diagnostic and therapeutic strategies face significant challenges in accurately identifying and localizing specific subtypes of breast cancer. In this study, we developed a novel machine learning-based predictor, BreCML, designed to accurately classify subpopulations of breast cancer cells and their associated marker genes. BreCML exhibits outstanding predictive performance, achieving an accuracy of 98.92% on the training dataset. Utilizing the XGBoost algorithm, BreCML demonstrates superior accuracy (98.67%), precision (99.15%), recall (99.49%), and F1-score (99.79%) on the test dataset. Through the application of machine learning and feature selection techniques, BreCML successfully identified new key genes. This predictor not only serves as a powerful tool for assessing breast cancer cellular status but also offers a rapid and efficient means to uncover potential biomarkers, providing critical insights for precision medicine and therapeutic strategies.

Estimating the health of turbine engine based on the relationship between torque margin and density altitude

We present an anomaly detection method developed for the PHM North America 2024 Conference Data Challenge. This competition is aimed at estimating the health of helicopter turbine engines (PHM Society, 2024). The task includes the estimation of the torque margin (regression) and the health state (binary classification) of turbine engines. We developed an estimation model using a hybrid algorithm that combines data-based machine learning and domain knowledge-based processing. Our method achieved scores over 0.99 for both the testing and validation datasets. based on the calculation rules provided by PHM Society. These results were ranked first among all the participating teams.

Automated detection of bone lesions using CT and MRI: a systematic review.

The aim of this study was to systematically review the use of automated detection systems for identifying bone lesions based on CT and MRI, focusing on advancements in artificial intelligence (AI) applications. A literature search was conducted on PubMed and MEDLINE. Data were extracted and grouped into three main categories, namely baseline study characteristics, model validation strategies, and the type of AI algorithms. A total of 10 studies were selected and analyzed, including 2,768 patients overall with a median of 187 per study. These studies utilized various AI algorithms, predominantly deep learning models (6 studies) such as Convolutional Neural Networks. Among machine learning validation strategies, K-fold cross-validation was the mostly used (5 studies). Clinical validation was performed using data from the same institution (internal testing) in 8 studies and from both the same and different (external testing) institutions in 1 study, respectively. AI, particularly deep learning, holds significant promise in enhancing diagnostic accuracy and efficiency. However, the review highlights several limitations, such as the lack of standardized validation methods and the limited use of external datasets for testing. Future research should address these gaps to ensure the reliability and applicability of AI-based detection systems in clinical settings.

Enhanced predictability and interpretability of COVID-19 severity based on SARS-CoV-2 genomic diversity: a comprehensive study encompassing four years of data.

Despite the end of the global Coronavirus Disease 2019 (COVID-19) pandemic, the risk factors for COVID-19 severity continue to be a pivotal area of research. Specifically, studying the impact of the genomic diversity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on COVID-19 severity is crucial for predicting severe outcomes. Therefore, this study aimed to investigate the impact of the SARS-CoV-2 genome sequence, genotype, patient age, gender, and vaccination status on the severity of COVID-19, and to develop accurate and robust prediction models. The training set (n = 12,038), primary testing set (n = 4,006), and secondary testing set (n = 2,845) consist of SARS-CoV-2 genome sequences with patient information, which were obtained from Global Initiative on Sharing all Individual Data (GISAID) spanning over four years. Four machine learning methods were employed to construct prediction models. By extracting SARS-CoV-2 genomic features, optimizing model parameters, and integrating models, this study improved the prediction accuracy. Furthermore, Shapley Additive exPlanes (SHAP) was applied to analyze the interpretability of the model and to identify risk factors, providing insights for the management of severe cases. The proposed ensemble model achieved an F-score of 88.842% and an Area Under the Curve (AUC) of 0.956 on the global testing dataset. In addition to factors such as patient age, gender, and vaccination status, over 40 amino acid site mutation characteristics were identified to have a significant impact on the severity of COVID-19. This work has the potential to facilitate the early identification of COVID-19 patients with high risks of severe illness, thus effectively reducing the rates of severe cases and mortality.

Application of CT-based foundational AI and radiomics models for prediction of outcome for non-small-cell lung cancer patients treated on the NRG/RTOG 0617 clinical trial

Abstract Objectives To apply CT-based foundational artificial intelligence (AI) and radiomics models for predicting overall survival (OS) for patients with locally advanced non-small cell lung cancer (NSCLC). Methods Data for 449 patients retrospectively treated on the NRG Oncology/Radiation Therapy Oncology Group (RTOG) 0617 clinical trial were analyzed. Foundational AI, radiomics and clinical features were evaluated using univariate cox regression and correlational analyses to determine independent predictors of survival. Several models were fit using these predictors and model performance was evaluated using nested cross-validation and unseen independent test datasets via area under receiver-operator-characteristic curves, AUC’s. Results For all patients, the combined foundational AI and clinical models achieved AUCs of 0.67 for the Random Forest (RF) model. The combined radiomics and clinical models achieved RF AUCs of 0.66. In the low-dose arm, foundational AI alone achieved AUC of 0.67, while AUC for the ensemble radiomics and clinical models was 0.65 for the support vector machine (SVM). In the high-dose arm, AUC values were 0.67 for combined radiomics and clinical models and 0.66 for the foundational AI model. Conclusions This study demonstrated encouraging results for application of foundational AI and radiomics models for prediction of outcomes. More research is warranted to understand the value of ensemble models toward improving performance via complementary information. Advances in knowledge Using foundational AI and radiomics-based models we were able to identify significant signatures of outcomes for NSCLC patients retrospectively treated on a national cooperative group clinical trial. Associated models will be important for application toward prospective patients.

Prediction of Dry Mouth Condition Using Radiomics Features from Tongue Diagnosis Image

Xerostomia, commonly known as dry mouth, is characterized by reduced salivary secretion, which can lead to various oral health issues and discomfort. In this paper, we propose a novel, non-invasive method for predicting xerostomia through the analysis of tongue images. To predict salivary gland secretion from tongue images, we collected images from patients who visited the hospital with complaints of dry mouth and measured their saliva secretion. Features were extracted from these tongue images, and correlation analysis was performed using machine learning techniques to assess the relationship between the extracted features and measured saliva secretion. We obtained tongue images and saliva secretion measurements from 176 patients. Images were cropped to 100 × 100 pixels, resulting in 462 features. The dataset was divided into training and test sets, consisting of 160 and 16 samples, respectively. The correlation coefficients for the training and test datasets were 0.9496 and 0.9415, respectively, while the correlation coefficient for the entire dataset was 0.9482. The estimated linear equation was y = 0.9244x + 2.1664. This study aimed to predict salivary gland secretion based on tongue images. By extracting features from color images and employing a neural network machine learning model, we estimated salivary gland secretion. With a sufficiently large dataset of tongue images, further advancements in regression analysis using deep learning techniques could enhance the accuracy of these predictions.

Temporal Convolutional Network-based Approach for Forecasting Fluctuations Differential Pressure in Reverse Osmosis Systems

Providing forecasts of pressure fluctuations and changes will aid in selecting appropriate maintenance strategies to optimize efficiency and costs. This paper presents a deep-learning-based model to forecast the degradation evolution of membrane biological fouling in RO (Reverse Osmosis) systems. Although applying deep learning in forecasting still faces many challenges, applying convolutional operations in convolution 1D has yielded promising results for sequential data, particularly time series data. Thus, in this paper we study and develop the 1D convolution operation-based Temporal Convolutional Network (TCN) model to predict pressure dynamics at both ends of the RO vessel. In addition, since the deep learning technique has yet to be widely explored in this field, thus we also need to pre-process the data collected from the Carlsbad Desalination Plant in California, such as the proposed model can identify complex relationships between timestamps and pressure features. The experiment results were evaluated and compared with other existing models, such as LSTM, CNN &amp; LSTM, and GRU. The obtain results show that the TCN-based prediction model had the slightest error in the test dataset.

Development of an automated artificial intelligence-based system for urogenital schistosomiasis diagnosis using digital image analysis techniques and a robotized microscope.

Urogenital schistosomiasis is considered a Neglected Tropical Disease (NTD) by the World Health Organization (WHO). It is estimated to affect 150 million people worldwide, with a high relevance in resource-poor settings of the African continent. The gold-standard diagnosis is still direct observation of Schistosoma haematobium eggs in urine samples by optical microscopy. Novel diagnostic techniques based on digital image analysis by Artificial Intelligence (AI) tools are a suitable alternative for schistosomiasis diagnosis. Digital images of 24 urine sediment samples were acquired in non-endemic settings. S. haematobium eggs were manually labeled in digital images by laboratory professionals and used for training YOLOv5 and YOLOv8 models, which would achieve automatic detection and localization of the eggs. Urine sediment images were also employed to perform binary classification of images to detect erythrocytes/leukocytes with the MobileNetv3Large, EfficientNetv2, and NasNetLarge models. A robotized microscope system was employed to automatically move the slide through the X-Y axis and to auto-focus the sample. A total number of 1189 labels were annotated in 1017 digital images from urine sediment samples. YOLOv5x training demonstrated a 99.3% precision, 99.4% recall, 99.3% F-score, and 99.4% mAP0.5 for S. haematobium detection. NasNetLarge has an 85.6% accuracy for erythrocyte/leukocyte detection with the test dataset. Convolutional neural network training and comparison demonstrated that YOLOv5x for the detection of eggs and NasNetLarge for the binary image classification to detect erythrocytes/leukocytes were the best options for our digital image database. The development of low-cost novel diagnostic techniques based on the detection and identification of S. haematobium eggs in urine by AI tools would be a suitable alternative to conventional microscopy in non-endemic settings. This technical proof-of-principle study allows laying the basis for improving the system, and optimizing its implementation in the laboratories.

Developing a 10-Layer Retinal Segmentation for MacTel Using Semi-Supervised Learning.

Automated segmentation software in optical coherence tomography (OCT) devices is usually developed for and primarily tested on common diseases. Therefore segmentation accuracy of automated software can be limited in eyes with rare pathologies. We sought to develop a semisupervised deep learning segmentation model that segments 10 retinal layers and four retinal features in eyes with Macular Telangiectasia Type II (MacTel) using a small labeled dataset by leveraging unlabeled images. We compared our model against popular supervised and semisupervised models, as well as conducted ablation studies on the model itself. Our model significantly outperformed all other models in terms of intersection over union on the 10 retinal layers and two retinal features in the test dataset. For the remaining two features, the pre-retinal space above the internal limiting membrane and the background below the retinal pigment epithelium, all of the models performed similarly. Furthermore, we showed that using more unlabeled images improved the performance of our semisupervised model. Our model improves segmentation performance over supervised models by leveraging unlabeled data. This approach has the potential to improve segmentation performance for other diseases, where labeled data is limited but unlabeled data abundant. Improving automated segmentation of MacTel pathology on OCT imaging by leveraging unlabeled data may enable more accurate assessment of disease progression, and this approach may be useful for improving feature identification and location on OCT in other rare diseases as well.

Comparing Feature and Trajectory-Based Remaining Useful Life Modeling of Electrical Resistance Heating Wires

Industrial heating significantly contributes to global greenhouse gas emissions, accounting for a substantial portion of annual emissions. The transition to fossil-free operations in the heating industry is closely linked to advancements in industrial electrical heating systems, especially those using resistance heating wires. In this context, Prognostics and Health Management is crucial for enhancing system reliability and sustainability through predictive maintenance strategies. The integration of machine learning technologies into Prognostics and Health Management has significantly improved the precision and applicability of Remaining Useful Life modeling. This improvement enables more accurate predictions of component lifespans, optimizes maintenance schedules, and enhances operational efficiency in industrial heating applications. These developments are essential for reducing greenhouse gas emissions in the sector. This paper serves as a guide for conducting Remaining Useful Life modeling for industrial batch processes. It evaluates and compares two methodologies: deep learning-based approaches using full time-series data, such as recurrent neural networks and their variants, and feature-engineering-based methods, including random forest regression and support vector machines. Our results show that the feature-oriented approach performs better overall in terms of predictive accuracy and computational efficiency. The study includes a detailed sensitivity analysis and hyperparameter estimation for each method, providing valuable insights into developing robust and transparent Prognostics and Health Management systems. These systems are crucial in supporting the heating industry’s move towards more sustainable and emission-free operations. The findings reveal that feature-oriented methods are both performant and robust, particularly excelling in handling outliers. The random forest regression model, in particular, demonstrated the highest performance on the test dataset according to the chosen evaluation metrics. Conversely, trajectory-oriented methods exhibited less bias across varying levels of degradation, a helpful characteristic for Prognostics and Health Management systems. While feature-oriented methods tend to systematically underestimate Remaining Useful Life at high true values and overestimate it at low actual values, this issue is less pronounced in trajectory-oriented models. Overall, these insights highlight the strengths and limitations of each approach, guiding the development of more effective and reliable predictive maintenance strategies.

Digital twin for decision support system of industrial utility management

Manufacturing and industrial operations rely heavily on energy that is generated mostly from fossil fuels, such as coal, oil, and natural gas, which harm the environment and contribute to climate change. Thus, renewable energy is being integrated into industrial processes to lessen environmental effects and reduce fossil fuel usage. However, the renewable source performance process can be greatly affected by disturbances and constraints, such as ambient air temperature and relative humidity, minimum utility consumption, and the total energy required, making effective control difficult. This study proposes a digital twin built with machine learning regression techniques for load demand forecasting as a decision-support system for industrial utility management. From the results, the ensemble tree (ET) model produced the highest accuracy, based on validation and test dataset root mean squared error values of 23.164 and 27.558, respectively, and R2 values of 0.96 and 0.95, respectively. The digital twin and load demand forecasting approaches effectively created an efficient operating schedule for industrial utility management. The ET model had a total error of 23.86%, substantially lower than the average load demand's total error of 65.29%. Therefore, the ET model with weather conditions in four scenarios could be recommended to optimize energy utilization when creating the operating schedule.