We reviewed our experience with retroperitoneal lymphadenectomy (rPLa) after multiple cisplatin-based chemotherapy regimens in nonseminomatous testicular tumors (NsTT) patients and specifically evaluated clinicopathologic and treatment trend in addition to potential predictors of survival. Fort-one patients with NsTT underwent their rPLa between 1982 and 2005 after ≥ 2 regimens of chemotherapy. Thirteen patients (32%) necessitate redo-rPLa, combined with nephrectomy in 6 patients. 13 extra-rP (ErP) resections were performed in 11 patients (27%), including pulmonary (7), neck (4) and liver (2) sites. Thirty patients (73%) are rendered free of disease and 26 (63%) obtained serologic remission. Nine patients who relapse, necessitated new salvage chemotherapy+surgery (3 teratoma, 6 vital carcinoma [VC]). Four of 9 relapsing patients (44%) are currently free of disease with redorPLa. alive, free of disease are 19 pts (46%) at median follow-up of 131 months. study of rP pathology demonstrated the presence of fibrosis in 15%, teratoma in 39% and VC in 46%, with survival in 67%, 56% and 32%, respectively. different histology occurred in 38% at redo-rPLa and in 64% at ErP resection in comparison to previous rP pathology. Univariate analysis of clinicopathologic parameters associated with VC at rPLa included rP masses ≥ 5 cm (p<0.05), elevated aFP (p<0.001) or HCG (p<0.05) and ErP resection (p<0.04). On univariate analysis survival was worse in patients with rP masses ≥ 5 cm (p<0.04), elevated aFP (p<0.05) or HCG (p<0.007), ErP resection (p<0.01) and VC (p<0.004). On multivariable analysis, a rP masses ≥ 5 cm (p<0.03) and VC (p<0.005) predicted a worse Patoloski nalaz i klinicki tok kod pacijenata sa metastazama neseminomskih testikularnih tumora kod kojih je primenjena retroperitonealna limfadenektomija posle multiplih hemoterapija Đordje M. argirovic1,3, aleksandar Đ. argirovic2 1Uroloska klinika, Klinicki Centar srbije “, Beograd 2Uroloska služba, Klinicko Bolnicki Centar Zemun, Beograd 3Poliklinika “argirovic, Beograd