Attention Test Research Articles

Patient-Reported Outcome Screens for Cognitive Dysfunction and Predicts Admissions in Cirrhosis

IntroductionHepatic encephalopathy (HE) is a frequent complication of cirrhosis, leading to preventable hospitalizations and increased mortality. Despite the availability of validated neuro-psychometric tests to diagnose HE, only 10% of clinicians regularly screen for HE due to lack of time, equipment, and trained personnel. Materials and MethodsWe studied the association between patient-reported cognitive function and the National Institutes of Health Toolbox Cognition Battery (a validated measure of HE) in patients with cirrhosis. A single-center prospective study of adult patients undergoing liver transplantation evaluation was performed from 10/2020 to 12/2021. Cognition was assessed using the National Institutes of Health Toolbox Cognition Battery and a brief Patient-Reported Outcomes Measurement Information System (PROMIS) survey. ResultsTwenty-three liver transplantation candidates were enrolled; the mean age was 56.4 (±9.7) years, 39% were female and the most common etiologies of cirrhosis were primary biliary cirrhosis/primary sclerosing cholangitis/overlap syndrome (30%), hepatitis C (22%) and alcohol-associated liver disease (22%). The mean MELD-Na was 14.9 (±6.4). The mean PROMIS Cognitive Function T-score (PROMISCF) was 49.2 (±9.6). The mean T-scores for the List Sort Working Memory test, Flanker Inhibitory Control and Attention test, and Pattern Comparison Processing Speed test were 46.4 (±9.9), 37.8 (±6.2), and 50.22 (±16.4), respectively. PROMISCF correlated with the List Sort Working Memory test (r = 0.45, P = .03). The mean hospitalization rate was 1.6 days admitted per month. On adjusted multivariate analysis, PROMISCF predicted total hospitalization days (P < .001), hospital admissions (P = .01), and hospitalization rate (P < .001). ConclusionsA brief survey can screen for HE and predict hospitalizations in patients with cirrhosis.

The Effect of Developmental Bottom-up Approach Through Perceptual-motor Interventions on Performance of Children With Mild Intellectual Disability

Background and Aims Intellectual disability manifests through defects in cognitive, motor, and perceptual skills as elements affecting learning and acquiring individual skills. Efforts to improve these skills are essential in these children. This study investigated the durable effects of perceptual-motor process-oriented interventions with the Ramon and Johnston protocol on the motor, cognitive, and perceptual performance of children with mild intellectual disability. Methods In this quasi-experimental research, 21 children with mild intellectual disability aged 7 to 12 years were selected using the available sampling method and according to the inclusion criteria. Then, they were assigned to an experimental group of 10 students (10 weeks of perceptual-motor intervention according to the Johnstone and Ramon protocol, two sessions per week) and a control group of 11 students (no intervention) using a simple random method. The participants were evaluated before and 2 months after the intervention with movement assessment battery for children 2nd Edition, Conners’ continuous performance test-II, the working memory test of Wechsler intelligence scale for children fourth edition, and the test of visual perception skills revised. Univariate covariance test was used for data analysis. Results The findings showed a significant difference between the intervention and control groups in general motor performance, aiming and catching, the correct answer in the attention test, visual sequential memory, and visual figure-ground in the delayed post-test stage (P&lt;0.05). Also, no significant difference was seen in other subtests (P&gt;0.05). Conclusion Bottom-up approach interventions through Ramon and Johnston’s comprehensive perceptual-motor training can significantly help improve general and ball motor skills, sustained attention, visual sequential memory, and visual figure-ground in children with mild intellectual disability.

Altered Functional Connectivity of the Thalamus Subregions Associated with Impaired Attention After Sleep Deprivation.

The thalamus plays a critical role in attentional maintenance. Previous studies have revealed the dysfunction of the thalamus in attention decline after acute sleep deprivation (SD). However, the functional connectivity (FC) between the thalamus subregions and cortical regions underlying attentional impairment after acute SD remains unclear. Here, we aimed to probe the relationship between attentional function and the altered thalamocortical FC after acute SD. In this study, 25 healthy participants with regular sleep conducted an attentional network test and received a resting-state fMRI scan before and after 24 hours of SD. Then, we analyzed the FC between the thalamus and cerebrum and relationships with attentional function in the enrolled subjects. Our results showed that the participants showed a significantly lower alerting effect, a higher executive effect, and lower accuracy after acute SD. Compared to the rested wakefulness state, we observed decreased FCs between the "somatosensory" thalamic seed and left frontal pole, right frontal pole, left middle temporal gyrus (posterior division), and right middle temporal gyrus (posterior division). Furthermore, the reduced FC between the right middle temporal gyrus and "somatosensory" thalamic seed was negatively associated with the change in orienting effect of the participants. Our findings reveal that the disrupted FC between thalamus subregions and cortical regions may contribute to impaired attention after SD.

Effect of Pitch Discrimination-Based Rehabilitation on Diagnostic Indices of Dichotic Digit Test, monaural Selective Auditory Attention Test, and Pitch Pattern Test in Children Suspected of Auditory Processing Disorder with Pitch Discrimination Deficits

Effect of Pitch Discrimination-Based Rehabilitation on Diagnostic Indices of Dichotic Digit Test, monaural Selective Auditory Attention Test, and Pitch Pattern Test in Children Suspected of Auditory Processing Disorder with Pitch Discrimination Deficits

Body composition, cardiovascular fitness and attention of school-aged male children practicing sports club activities: A cross-sectional.

The positive effects of physical activity on physical fitness, bone health, academic achievement, cognitive functions, mental health, and reduced obesity have been proven. This study aims to investigate the relationship between sports club activities, physical activity selected health-related fitness, and the d2 attention test. A cross-sectional study was conducted in different sports clubs. A total of 78 male students aged 10-13 years participating in various branches of sports clubs were included in the study, 42 of whom were assigned to the sports group and 36 to the control group. Questionnaires were administered to assess sports club participation and attention levels, while physical health profiles were tested with body composition and Yo-Yo IR1C performance measures. Data were analyzed according to sports participation and the five most frequently reported sports. The means and standard deviation of each study value were calculated for the total subjects and by participating in sports activity using the IBM SPSS (version 23) analysis program. Data normality was checked and confirmed by the Skewness and Kurtosis Tests. The results showed that boys enrolled in a sports activity had lower body mass (-17.9%, P < 0.05 d = 0.72), body mass index (-13.4%, P < 0.05, d = 0.87), and body fat (%) (-54.1%, P < 0.05, d = 1.38) and higher VO2max 32.3% (P < 0.05, d = 3.67), than the non-active group. The boys active in sports clubs also had better results in the total number of items processed (11%, P < 0.05 d = 0.50) and in concentration performance (17.7%, P < 0.05 d = 0.56) than the non-active group. In correlation analyses, VO2max was negatively associated with body mass, body mass index, and body fat (P = 0.011; P = 0.001 and P = 0.00, respectively) and positively related to the total number of items processed and concentration performance (P = 0.003 and P = 0.015, respectively). In the Pearson Correlation analyses, body fat showed a lower negative correlation with TN (r = 0.33; P = 0.003) and CP (r = 0.28; P = 0.015). Boys participating in regular sports have lower body mass, BMI, and BF values. In addition, boys who participated in sports showed higher imaginary fitness and selective attention and concentration capacity results, as expected, for any sports part compared to their body peers. Another attempt from this study is that body mass and body fat percentage recovery are negatively associated with fitness. Considering the increasing prevalence of obesity in children and adolescents due to sedentary living, which has become a worldwide epidemic, it is recommended that pedagogical and public health strategies and policies be developed based on the physical fitness level of children.

Frontal cortex neurometabolites and mobility in older adults: a preliminary study.

The frontal cortex, relevant to global cognition and motor function, is recruited to compensate for mobility dysfunction in older adults. However, the in vivo neurophysiological (e.g., neurometabolites) underpinnings of the frontal cortex compensation for mobility dysfunction remain poorly understood. The purpose of this study was to investigate the relationships among frontal cortex neurophysiology, mobility, and cognition in healthy older adults. Magnetic Resonance Spectroscopy (MRS) quantified N-acetylasparate (tNAA) and total choline (tCho) concentrations and ratios in the frontal cortex in 21 older adults. Four inertial sensors recorded the Timed Up & Go (TUG) test. Cognition was assessed using the Flanker Inhibitory Control and Attention Test which requires conflict resolution because of response interference from flanking distractors during incongruent trials. Congruent trials require no conflict resolution. tNAA concentration significantly related to the standing (p = 0.04) and sitting (p = 0.03) lean angles. tCho concentration (p = 0.04) and tCho ratio (p = 0.02) significantly related to TUG duration. tCho concentration significantly related to incongruent response time (p = 0.01). tCho ratio significantly related to both congruent (p = 0.009) and incongruent (p < 0.001) response times. Congruent (p = 0.02) and incongruent (p = 0.02) Flanker response times significantly related to TUG duration. Altered levels of frontal cortex neurometabolites are associated with both mobility and cognitive abilities in healthy older adults. Identifying neurometabolites associated with frontal cortex compensation of mobility dysfunction could improve targeted therapies aimed at improving mobility in older adults.

A novel approach to assessing the joint effects of mercury and fish consumption on neurodevelopment in the New Bedford Cohort

Abstract Understanding health risks from methylmercury (MeHg) exposure is complicated by its link to fish consumption, which may confound or modify toxicities. One solution is to include fish intake and a biomarker of MeHg exposure in the same analytical model, but resulting estimates do not reflect the independent impact of accumulated MeHg or fish exposure. In fish-eating populations, this can be addressed by separating MeHg exposure into fish intake and average mercury content of the consumed fish. We assessed the joint association of prenatal MeHg exposure (maternal hair mercury level) and fish intake (among fish-eating mothers) with neurodevelopment in 361 children aged 8 years from the New Bedford Cohort (New Bedford, Massachusetts; born in 1993-1998). Neurodevelopmental assessments used standardized tests of IQ, language, memory, and attention. Covariate-adjusted regression assessed the association of maternal fish consumption, stratified by tertile of estimated average fish mercury level, with neurodevelopment. Associations between maternal fish intake and child outcomes were generally beneficial for those in the lowest average fish mercury tertile but detrimental in the highest average fish mercury tertile, where, for example, each serving of fish was associated with 1.3 fewer correct responses (95% CI, −2.2 to −0.4) on the Boston Naming Test. Standard analyses showed no outcome associations with hair mercury level or fish intake. This article is part of a Special Collection on Environmental Epidemiology.

Towards an Objective Measurement Tool for ADHD-like Traits in Family Dogs: A Comprehensive Test Battery.

Family dogs exhibit neuropsychological deficits similar to attention-deficit/hyperactivity disorder (ADHD) symptoms in humans. Questionnaire methods have mostly been used to assess ADHD-like behaviours in dogs. In addition to our validated questionnaire (Dog ADHD and Functionality Rating Scale-DAFRS; 2024), we developed a simple behavioural test battery covering the ADHD symptom domains (i.e., inattention, hyperactivity, and impulsivity) in dogs. Our main aim was (i) to provide a final external validation step to the DAFRS by examining its associations with the test variables (N = 59); and (ii) to compare owner- and trainer-rated factor scores' associations with the test variables (n = 38). We developed four tests covering the ADHD symptom domains: the attention test (inattention), the plush dog test (impulsivity), the leash test, and the sit test (hyperactivity). All four behavioural variables correlated with their respective questionnaire scores, i.e., the strongest for hyperactivity, and the least strong for inattention. Both owner- and trainer-rated scores (n = 38) correlated with the relevant test variables in an expected direction. Dogs' training status was linked only to the sit test results. Test-retest analyses (n = 34) indicated moderate-to-excellent agreement across all behavioural variables. Our findings support the validity of our novel human-analogue questionnaire for dogs as the behavioural tests strongly correlate with the relevant questionnaire scores, indicating that the two constructs together can effectively assess inattention, hyperactivity, and impulsivity in dogs.

QOL-26. SYTHESIS OF THE LITERATURE REVIEW ON PHYSICAL ACTIVITY IN PEDIATRIC NEURO-ONCOLOGY

Abstract BACKGROUND Physical Activity plays a vital role in physical, social, phychological wellbeing of pediatric neuro-oncologic group. However, the researches investigating the effects of physical activity on this group have been sparse. The purpose of this study was to identify studies conducted about the effects of physical activity on this population. METHODS PRISMA statement conduct review was followed in electronic database of Journal of Neuro-oncology. Two authors (SY, MT) independently conducted systematic literature searches February 2024. Keywords/Mesh terms: “physical activity’’. Randomized controlled English clinical trials are included; Studies that were published as “review”, “protocol”, “books”, “news”, not reach full text and not related to physical activity excluded. After articles had been reached, used QUADAS-2 checklist for methodological quality. RESULTS 29 articles were identified from 1721 articles, and 2 of them (published 2014-2023) were about pediatric age group. One of them was assessment (50%), while the other one was interventional study (50%). Assessment study was measured by using Bruininks-Osteretsky Test of Motor Performance, Second Edition (BOT-2) and online surveys. Interventional study analyzed the effects of aerobic exercises of three 90-minute sessions per week for 12 consecutive weeks primarily on cortical thickness, white matter, hippocampal volume and secondarily reaction time, accuracy across tests of attention, processing speed, and short term memory. CONCLUSION This abstract provides an initial scoping review of physical activity in pediatric neuro-oncology group. It demonstrates limited range of assessments, and interventions which highlights the lack of clinical evidence in this specific area. The results raise the need for further research in this field to help the development of physical activity guidelines for evaluation and physical activity methods in children with ataxia, and tumours expecially posterior fossa brain tumors. Investigation of different physical activity methods in a group of neuro-oncology children in need of support is major importance.

Effects of Cognitive and Physical Exercise on Soccer Penalty Kicking

Abstract: This exploratory study examined the effects of previous exercise on goal-side selection in soccer penalty kicking. Two types of 30-min exercise were tested and compared with a control group in an off-center paradigm. The cognitive-exercise group performed the d2 test of attention and the physical-exercise group rode on a fitness bicycle. In the off-center paradigm, participants viewed images of a goalkeeper in a soccer goal, who stood either in the middle of the goal or slightly displaced to the left or right. During the experiment, all participants selected the greater goal side for kicking when they perceived the goalkeeper’s position in the middle of the goal (i. e., off-center effect). However, only participants of the cognitive-exercise group demonstrated a strong bias for the right goal side, indicating visual–spatial pseudoneglect for the goalkeeper position. Therefore, only previous cognitive and not physical exercise appears to affect perception and decision-making in soccer penalty kicking.

The accuracy of bedside attention tests for delirium detection in older outpatients with cognitive impairment

BackgroundTo determine the test accuracy of four observations, three explorations and four short tests commonly used in psychiatric examinations to detect attention disorders related to delirium in older outpatients. MethodWe performed a test accuracy study among 86 older patients referred for cognitive screening to an outpatient clinic of a psychiatric institution. Eleven index tests were applied without knowledge of the reference standard. A geriatrician or psychiatrist blinded to the results of the index tests determined the reference diagnosis with DSM-IV-TR criteria. Observations were lack of adequate/ regular eye-contact, dozing off during conversation, dozing off when not stimulated, and losing the point of story. Explored was lack of concentration during activities, difficulty following conversation, and being easily distracted. Serial 7s, WORLD spelled backward, months of the year backward (MOTYB) and counting back from 20 to 0 were applied. Test accuracy was calculated for the single tests and combinations. ResultsDozing off during conversation scored high specificity (97.9 %) as did dozing off when not stimulated (97.9 %), but both had low sensitivity (< 27.9 %). Test accuracy of the exploration questions was low. Serial 7s and WORLD spelled backwards had high sensitivity (92.7 %, respectively 80.5 %) but low specificity (< 51.1 % %). The best combination was MOTYB with WORLD spelled backward (sensitivity of 63.4 %, specificity of 77.8 %). ConclusionsNo single observation, exploration or short test of attention was found to have both high sensitivity and specificity. Probably, attention deficits in delirium are best detected with a combination of observations and short tests as part of a comprehensive psychiatric examination.

Assessing neural markers of attention during exposure to construction noise using machine learning classification of electroencephalogram data

Construction noise is one of the leading causes of attention impairment both for workers within construction sites and individuals in their direct vicinity. Distraction caused by construction noise can significantly affect productivity of people in the surrounding area. In addition, lack of adequate attention by workers in construction sites can increase the risk of mistakes potentially increasing work-related accidents. This study highlights the feasibility of using electroencephalogram (EEG) data for detecting distractions caused by construction noise. EEG data were collected from 23 participants while they completed a standard attention test (Go-NoGo) during exposure to construction noise. Both frequency-based features and non-linear features were extracted from the EEG signal and subject-independent machine learning models were applied. The results showed that channel FC5, with an F1 score of 68.41 % and an accuracy score of 70.28 % presented the best performance among all channels and the defined channel clusters. These findings will help inform the best features and channels to select for developing new purpose-built EEG devices with a smaller number of channels that are suited for distraction detection due to noise exposure in construction sites.

Neurocognitive and Neuropsychiatric Sequelae in Long COVID-19 Infection.

Objective: To characterize the cognitive profile of long COVID-19 subjects and its possible association with clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: We performed a single-center cross-sectional cohort study. Subjects between 20 and 60 years old with confirmed COVID-19 infection were included. The assessment was performed 6 months following hospital or ambulatory discharge. Excluded were those with prior neurocognitive impairment and severe neurological/neuropsychiatric disorders. Demographic and laboratory data were extracted from medical records. Results: Altogether, 108 participants were included, 64 were male (59.25%), and the mean age was 49.10 years. The patients were classified into four groups: non-hospitalized (NH, n = 10), hospitalized without Intensive Care Unit (ICU) or oxygen therapy (HOSPI, n = 21), hospitalized without ICU but with oxygen therapy (OXY, n = 56), and ICU (ICU, n = 21) patients. In total, 38 (35.18%) reported Subjective Cognitive Complaints (SCC). No differences were found considering illness severity between groups. Females had more persistent clinical symptoms and SCC than males. Persistent dyspnea and headache were associated with higher scores in anxiety and depression. Persistent fatigue, anxiety, and depression were associated with worse overall cognition. Conclusions: No cognitive impairment was found regarding the severity of post-COVID-19 infection. SCC was not associated with a worse cognitive performance, but with higher anxiety and depression. Persistent clinical symptoms were frequent independent of illness severity. Fatigue, anxiety, and depression were linked to poorer cognitive function. Tests for attention, processing speed, and executive function were the most sensitive in detecting cognitive changes in these patients.

Does acute aerobic exercise enhance selective attention, working memory, and problem-solving abilities in Alzheimer's patients? A sex-based comparative study.

The present study aimed to evaluate the effect of acute aerobic exercise on certain cognitive functions known to be affected by Alzheimer's disease (AD), with a particular emphasis on sex differences. A total of 53 patients, with a mean age of 70.54 ± 0.88 years and moderate AD, voluntarily participated in the study. Participants were randomly assigned to two groups: the experimental group (EG), which participated in a 20-min moderate-intensity cycling session (60% of the individual maximum target heart rate recorded at the end of the 6-min walk test); and the control group (CG), which participated in a 20-min reading activity. Cognitive abilities were assessed before and after the physical exercise or reading session using the Stroop test for selective attention, the forward and backward digit span test for working memory, and the Tower of Hanoi task for problem-solving abilities. At baseline, both groups had comparable cognitive performance (p > 0.05 in all tests). Regardless of sex, aerobic acute exercise improved attention in the Stroop test (p < 0.001), enhanced memory performance in both forward (p < 0.001) and backward (p < 0.001) conditions, and reduced the time required to solve the problem in the Tower of Hanoi task (p < 0.001). No significant differences were observed in the number of movements. In contrast, the CG did not significantly improve after the reading session for any of the cognitive tasks (p > 0.05). Consequently, the EG recorded greater performance improvements than the CG in most cognitive tasks tested (p < 0.0001) after the intervention session. These findings demonstrate that, irrespective to sex, a single aerobic exercise session on an ergocycle can improve cognitive function in patients with moderate AD. The results suggest that acute aerobic exercise enhances cognitive function similarly in both female and male patients, indicating promising directions for inclusive therapeutic strategies.

Effect of Cogmed Working Memory Training on Auditory Attention Span of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD)

Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and/or impulsiveness. The studies on non-pharmacological treatment for ADHD are rather sparse. In India, usually, ADHD is assessed using rating scales, and not much importance is given on selective attention, that is, auditory and/or visual. Kofler 1 hypothesized a functional relationship between working memory (WM) and inattention. The current research was planned to study the effect of Cogmed Working Memory Training (CWMT) program on various parameters of the auditory attention span of children and adolescents having ADHD. Methods: A total of 30 children were taken for the current study. Parental consent was taken. Auditory attention span of the sample was measured by the Continuous Auditory Test of Attention (CATA). After pre-assessment, the children underwent CWMT program for 5 weeks. Cogmed is a scientifically researched program, which has been recommended to be used for improvement of WM and attention. At the end of the training, the children were reassessed by the abovementioned tool, CATA. t-test was used to analyze the pre-intervention and post- intervention data for auditory inattentiveness, impulsivity, sustained attention, and two age groups. Mann-Whitney U-test was used to analyze the comparison between male and female gender groups. Results: Results indicate the effectiveness of Cogmed Working Training Program on auditory attention span of children with ADHD. Conclusion: The results need to be validated if the improvement is sustained over a period of time with follow up assessment.

Vaporized Δ9-tetrahydrocannabinol exposure in utero has negative effects on attention in a dose- and sex-dependent manner

There has been an increasing use of cannabis during pregnancy in recent years. Studies have indicated that THC exposure in utero may increase the risk of attention deficits and memory impairments in adolescence. The goal of the present study is to investigate the effects of vaporized THC exposure during pregnancy on offspring memory and attention performance in early and late adolescence. Pregnant dams were exposed to vaporized THC (10 mg or 40 mg) daily from gestational day 2 until labor. Pups were given either a standard or a high-fat diet at weaning and tested in early and late adolescence in two memory tests, the Novel Object Recognition (NOR) test and the Morris Water Maze (MWM) test, and a test of attention, the Object-Based Attention (OBA) test. Rats exposed to low-dose THC showed significantly decreased object exploration in both the NOR and OBA tests, indicating decreased attention. Object exploration time in OBA was significantly lower in females than males. Additionally, post hoc analysis of MWM tests showed some differences in learning patterns for HD THC offspring in early adolescence, possibly due to diet interaction, but ultimate performance was not impacted. While there are existing studies examining prenatal exposure to THC in rodents, this is the first to our knowledge examining memory and attention in adolescence following vaporized THC exposure in utero, and we find indications that prenatal THC exposure may lead to attention deficits and altered memory performance.

The Vocal Quality of the Sender is Able to Influence the Cognitive Performance and Cortisol Level of the Listener

To verify the influence of the sender's vocal quality on performance in cognitive tests and on the receiver's cortisol level. Observational, cross-sectional, and analytical study. Four voices were selected to represent adapted voice (AdV), and rough voice of discreet degree (DV), moderate (MV), and intense (IV). These participants recorded the stimuli used in the attention and memory tests, which included 139 undergraduate students as receivers. Saliva was collected from recipients for cortisol assessment one minute before and after 15, 30 and 45minutes of the cognitive assessment. Statistically significant differences were identified between the groups in the repetition test, with worse results in IV. Cortisol increased significantly in the MV group when compared with the other groups after 15minutes of the cognitive test. Emitters' rough voices can negatively influence performance in cognitive tests that require attention and working memory and leads to a short-term increase in the receiver's cortisol levels.

Mild Dehydration Triggered by Exercise Reduces Cognitive Performance in Children, But Does Not Affect Their Motor Skills

Objective Children face the risk of dehydration in varying amounts during the day due to reasons such as physical activity, sweating, eating salty foods and drinking carbonated beverages. It is assumed that dehydration can lead to impaired motor skills and cognitive performance since it affects brain function. However, inconsistencies in study results, test times and problems caused by heat stress make new research mandatory. In our research, we examined the effects of exercise-induced mild dehydration on motor skills and cognitive performance in active/sedentary boys who do/do not do regular physical activities in their daily lives. Methods The study included 112 boys who do regular physical activity (n:57; 12.40 ± 0.49age) and sedentary (n:55; 12.49 ± 0.50age). The children were given a 12-h hydration program. Mild dehydration was created by giving exercises after hydration measurements. In case of hydration and mild dehydration, Bruininks-Oseretsky Motor Proficiency and d2 attention test were applied to the children. For comparison, Repeated Measures ANOVA and Bonferroni post-hoc test was performed at the second level. Results According to the hydration and mild dehydration comparison results, there was no difference in total score of Fine Motor Skill Sensitivity, Fine Motor Skill Integration, Hand Dexterity and Bidirectional Coordination, Balance, Running Speed and Agility, Hand-Arm Coordination, Strength, and BOT-2 in children. There was a decrease in both groups in terms of Focused Attention, Processing Speed, Accuracy, Concentration Performance and Attention Span. Conclusion As a result, mild dehydration is associated with daily physical activity in children (physical education classes, etc.) or it can easily occur due to food/beverage preferences. It may affect children’s performance of school curriculum and extracurricular activities. It shows that maintaining optimal hydration is important.

Decreased frontal theta frequency during the presence of smartphone among children: an EEG study.

Smart devices have become an integral part of our lives. However, research has highlighted the potential implications of smartphone presence on task performance, particularly in young children. This study aimed to determine the effect of a smartphone presence on brainwaves associated with cognitive interruption in children. EEG data were collected from 5.3 to 8.5-year-old children performing a simple reaction time task with and without the presence of a smartphone. Theta and alpha bands were calculated, and repeated measure analysis of variance was performed to assess the impact of two conditions on alpha and theta bands: 1) with the presence and; 2) without the presence of a smartphone. EEG waveforms were also correlated with standardized cognitive measures evaluating attention abilities using Pearson correlation. Theta and alpha activity values were higher in the absence vs the presence of a smartphone, with a significant difference between theta bands for the two study conditions. Moreover, the difference between theta bands in the two conditions was significantly correlated with lower scores on an auditory attention test. The existence of an interactive electronic device during cognitive tasks is associated with alterations in brain activity related to cognitive control. The presence of a smartphone during a simple reaction time task in young children was associated with a significant decrease in frontal theta frequency. A trend of a decreased alpha band in the presence of a smartphone. The differences in theta and alpha frequencies between conditions were significantly correlated with lower scores in auditory and visual attention and inhibition tests.

Protective effect of melatonin against methamphetamine-induced attention deficits through miR-181/SIRT1 axis in the prefrontal cortex.

Methamphetamine (METH) is an addictive psychostimulant with deleterious effects on the central nervous system. Chronic use of METH in high doses impairs cognition, attention and executive functions, but the underlying mechanisms are still unclear. Sirtuin 1 (SIRT1) is a post-translational regulator that is downregulated following METH neurotoxicity. Melatonin is a neuroprotective hormone that enhances mitochondrial metabolism. Here, we evaluated the effect of melatonin on METH-induced attention deficits disorder and the involvement of the miR-181/SIRT1 axis in melatonin neuroprotection. METH at a dose of 5mg/kg was injected for 21 consecutive days. The animals were assigned to receive either melatonin or the vehicle after METH injections. Attention levels were evaluated with abject-based attention test. In the prefrontal cortex, the expression levels of miR-181a-5p, SIRT1, p53 and CCAR2, as well as the mtDNA copy numbers were evaluated using qRT-PCR and western blotting. The outcomes revealed that melatonin treatment following METH injections improved METH-induced attention deficits. METH toxicity can be associated with changes in the miR-181/SIRT1 axis, elevated levels of p53 and COXII, and decreased levels of mtDNA in the prefrontal cortex of adult rats. Interestingly, administration of melatonin can improve the expression of these molecules and reduces the toxic effects of METH. Melatonin ameliorated the neurotoxicity of METH in the prefrontal cortex and the miR-181/SIRT1 axis is involve in the protective effects of melatonin. However, melatonin can be potentially administrated to improve attention impairment in METH use disorders.