Test For Paired Data Research Articles

Association Between Hormonal Status, Stress, Recovery, and Motivation of Paralympic Swimmers

ABSTRACT Purpose: The present study aimed to investigate associations between hormonal profile (cortisol and testosterone) and the psychobiological aspects of Paralympic athletes during a competitive season. Method: Male Brazilian Paralympic swimmers (n = 11) were evaluated in three Training Camps (TC) during the cycle of training for the Paralympic Games RIO 2016. Questionnaires were used for data collection of stress and recovery, motivation in sport and hormonal status was assessed by salivary samples of cortisol ([Csal]) and testosterone ([Tsal]) concentrations. The Friedman test was used to identify overall significant differences at the three TC for each variable. When the overall p value indicated statistical significance (p < .05), a post hoc Wilcoxon signed-rank test for paired data was used to compare pairs of TC. The Spearman correlation was used to identify associations between the hormonal profile and the psychobiological aspects. Results: There was an association between the [Csal] and the “Conflicts/Pressure” sub-scale (r = 0.60; p = .04) in TC1 and the “Lack of Energy” subscale (r = 0.63; p = .03) in TC2. In the TC3, there were correlations between [Tsal] and “To Know” intrinsic motivation (r = 0.83, p < .01), “Objectives”(r = 0.66, p < .02), “Experiences” (r = 0.65, p < .02) and “Amotivation” (r = −0.70, p = .01). There were also associations between the [Tsal] and the “Social Recovery” (r = 0.77, p < .01), “General Wellness” (r = 0.73, p < .01), “Sleep Quality” (r = 0.63, p = .03) and “Self-efficacy” (r = 0.60, p = .05) subscales. In TC3, there was an association between [Tsal] and the “Success” (r = 0.61, p = .04), “Sleep Quality” (r = 0.62, p = .03), “Personal Accomplish” (r = 0.82, p < .01), “Self-efficacy” (r = 0.82, p < .05), “Self-regulation” (r = 0.85, p < .01) and “Physical Recovery” (r = 0.80, p < .01) subscales. The data demonstrate associations between biomarkers (salivary testosterone and cortisol) and psychobiological domains of Paralympic swimmers.

Non-invasive evaluation of macro- and microhemodynamic changes during induction of general anesthesia - A prospective observational single-blinded trial.

Hypotension and bradycardia are known side effects of general anesthesia, while little is known about further macro- and microhemodynamic changes during induction. Intriguing is furthermore, why some patients require no vasopressor medication to uphold mean arterial pressure, while others need vasopressor support. Determination of macro- and microhemodynamic changes during induction of general anesthesia. We enrolled 150 female adults scheduled for gynaecological surgery into this prospective observational, single-blinded trial. Besides routinely measuring heart rate (HR) and mean arterial blood pressure (MAP), the non-invasive technique of thoracic electrical bioimpedance was applied to measure cardiac output (CO), cardiac index (CI), stroke volume (SV), stroke volume variability (SVV) and index of myocardial contractility (ICON) before induction of anesthesia, 7 times during induction, and, finally, after surgery in the recovery room. Changes in microcirculation were assessed using sidestream dark field imaging to establish the perfused boundary region (PBR), a validated gauge of glycocalyx health. Comparisons were made with Friedman's or Wilcoxon test for paired data, and with Mann-Whitney-U test for unpaired data, with post-hoc corrections for multiple measurements by the Holm-Bonferroni method. 83 patients did not need vasopressor support, whereas 67 patients required therapy (norepinephrine, atropine or cafedrine/theodrenaline) to elevate MAP values to ≥70mmHg during induction, 54 of these receiving norepinephrine (NE) alone. Pre-interventional (basal) values of CO, CI, ICON, SV and SVV were all significantly lower in the group of patients later requiring NE (p < 0.04), whereas HR and MAP were identical for both groups. HR, MAP and CO decreased from baseline to 12 min after induction of general anesthesia in both the patients without and those with NE support. Heart rate decreased significantly by about 25% in both groups (-19 to -21 bpm). The median individual decrease of MAP amounted to -26.7% (19.7/33.3, p < 0.001) and -26.1% (11.6/33.2, p < 0.001), respectively, whereas for CO it was -40.7% (34.1/50.1, p < 0.001) and -43.5% (34.8/48.7). While these relative changes did not differ between the two groups, in absolute values there were significantly greater decreases in CO, CI, SV and ICON in the group requiring NE. Noteably, NE did not restore ICON or the other cardiac parameters to levels approaching those of the group without NE. PBR was measured in a total of 84 patients compiled from both groups, there being no intergroup differences. It increased 6.4% (p < 0.001) from pre-induction to the end of the operation, indicative of damage to microvascular glycocalyx. Non-invasive determination of CO provides additional hemodynamic information during anesthesia, showing that induction results in a significant decrease not only of MAP but also of CO and other cardiac factors at all timepoints compared to baseline values. The decrease of CO was greater than that of MAP and, in contrast to MAP, did not respond to NE. There was also no sign of a positive inotropic effect of NE in this situation. Support of MAP by NE must consequently result from an increase in peripheral arterial resistance, posing a risk for oxygen supply to tissue. In addition, general anesthesia and the operative stimulus lead to an impairment of the microcirculation.

Exergaming Effects on Physical Activity Beliefs and Intention among At-Risk Hispanic Youth

With the increase of childhood obesity and sedentary behavior, it is essential to discover innovative ways to motivate youth to be more active. Many Hispanic children in the United States in obesogenic environments particularly lack opportunities for physical activity (PA). Exergames (i.e., motion-based video games) may enhance PA among at-risk populations. This study investigated the impact of exergaming on at-risk, Hispanic high school students with respect to physical activity self-efficacy (PA-SE), PA enjoyment, and intention to be physically active through a 10-week Exergaming Activity Program. Instrumentation included the PA-SE Questionnaire and the PA Enjoyment Scale. Paired-samples t-tests, confirmed by Wilcoxon signed rank tests for paired data, revealed that PA-SE, PA enjoyment, and PA intention increased from the beginning to the end of the program, but PA intention was the only measure that was statistically significant. Results provide insight for physical educators and PA leaders into a possible way to increase PA among at-risk youth living in environments where outside PA opportunities are scarce or unsafe.

The impact of a "narrative interview" intervention in oncology. A study protocol for a feasibility study.

Background and aim of the work.Oncological diagnosis determines a biographical breakdown and requires the person to adapt to the disease. If patients, after diagnosis, ask professionals for ‘compassionate care’, research on these issues is still underdeveloped. There are currently no studies that use the narrative interview as an intervention tool. The objectives of the study are to evaluate: (1) the feasibility of the narrative interview intervention on cancer patients in the first diagnosis; (2) the impact of the narrative medicine intervention on the patient’s self-perception, his psychological distress and adaptation to the disease.Methods.It is a mixed-method study, with an intervention (narrative interview) and quantitative evaluation before/after intervention and qualitative evaluation post-intervention (reflective writing). The analysis will use the Psychological Distress Inventory scale for the assessment of psychological distress and the Mini-Mental Adjustment to Cancer Scale for the assessment of disease adaptation. Adult patients, with oncological pathology will be recruited one month after the communication of the diagnosis, regardless of the type of tumor. The Wilcoxon test for paired data will be used to verify pre-post-intervention differences. The ‘reflective writings’ will be subjected to thematic analysis.Discussion and conclusion.The study evaluates the feasibility of the narrative interview intervention as a primary outcome. Secondly, the impact of the intervention is assessed in relation to: a) identification of risk or protective factors on psychological distress and adaptation to the disease; b) re-elaboration of the patient’s experiences and experiences related to his/her own illness. (www.actabiomedica.it)

Agreement between Framingham, IraPEN and non-laboratory WHO-EMR risk score calculators for cardiovascular risk prediction in a large Iranian population.

Introduction: Estimation of the risk of cardiovascular diseases (CVD), may lead to prophylactic therapies. This study aims to compare and evaluate the agreement between CVD prediction of Iran Package of Essential Non-communicable Disease (IraPEN) and Framingham risk score (FRS). Methods: All 40-79 years old participants in the Yazd Health Study who did not have a history of CVD were included. The 10-years risk of CVD was estimated by the laboratory (IraPEN), non-laboratory WHO-EMR B and FRS. The risk was classified into low, moderate and high-risk groups. Cohen’s weighted kappa statistics were used to assess agreement between tools. To assess discrepancies McNemar’s χ2 test for paired data was used. P values < 0.05 were considered statistically significant. Results: In total, 2103 participant was included and the risk scores were calculated. Of them, 26.5% were stratified as high risk by FRS, compared with 6.1% by IraPEN. A slight agreement (37.9%) was observed (kappa 0.17, P < 0.0001), in other words. This discrepancy between IraPEN vs. FRS was seen in both sexes (P < 0.0001), although in women the agreement ratio was higher (52.1% vs. 21.3%). The discrepancy between FRS and IraPEN in categorizing people at risk of CVD was 55.5%, (P < 0.0001) but this was not significant between IraPEN and non-laboratory WHO-EMR-B (World Health Organization - Eastern Mediterranean Regional-B group countries) score (P < 0.523; discrepancies, 5.8%). Conclusion: Our study shows a slight agreement between various CVD risk scores. Thus, reviewing the IraPEN and using alternative tools for the low-risk group should be considered by decision-makers. It is important to use a more reliable score for nation-wide risk assessment.

Associations Between Features of Nonstenosing Carotid Plaque on Computed Tomographic Angiography and Ischemic Stroke Subtypes.

BackgroundThromboembolism from nonstenosing carotid plaques may be an underrecognized cause of embolic strokes of undetermined source (ESUS). We evaluated the association between features of nonstenosing atherosclerotic plaque on computed tomographic angiography and ESUS.Methods and ResultsWe identified consecutive acute ischemic stroke patients from 2011 to 2015 who had unilateral anterior territory infarction on brain magnetic resonance imaging and a neck computed tomographic angiography. We included ESUS cases and as controls, cardioembolic strokes. Patients with ≥50% internal carotid artery atherosclerotic stenosis ipsilateral to the stroke were excluded from this analysis. Reviewers blinded to infarct location and stroke cause retrospectively evaluated computed tomographic angiography studies for specific plaque features including thickness of the total, soft, and calcified plaque; presence of ulceration; and perivascular fat attenuation. Paired t tests and McNemar's test for paired data were used to compare plaque features ipsilateral versus contralateral to the side of infarction. Ninety‐one patients with ESUS or cardioembolic stroke were included in this study. Total plaque thickness was greater on the infarcted side (2.1±2.0 mm) than the contralateral side (1.2±1.5 mm) (P=0.006) among ESUS cases, but not among cardioembolic cases (1.9±1.6 mm versus 1.8±1.6 mm) (P=0.32).ConclusionsAmong ESUS cases, total plaque thickness was greater ipsilateral to the side of infarction than on the contralateral, stroke‐free side. No such side‐to‐side differences were apparent in cardioembolic strokes. Our findings suggest that nonstenosing large‐artery atherosclerotic plaques represent one underlying mechanism of ESUS.

Stability of hepatitis B viral load during pregnancy and implications for antepartum prophylaxis: A prospective cohort study.

We examined changes in hepatitis B virus (HBV) viral loads (VLs) in pregnancy, their association with hepatitis B e antigen (HBeAg), and the associated infant outcomes. We prospectively followed 132 mothers positive for hepatitis B surface antigen (HBsAg) and their 135 infants from 2011 to 2015 in Vancouver, British Columbia. Outcome measures included association between maternal HBeAg and high (>200,000 IU/mL) or low (≤200,000 IU/mL) HBV VL, changes in HBV VL through pregnancy, infant HBsAg status, and infant completion of the HBV vaccination series. f the 91 participants with an available HBV VL, 13 (14.3%) had an HBV VL of more than 200,000 IU/mL. Of 59 participants with paired HBeAg and HBV VL in pregnancy, 6 had an HBV VL of more than 200,000 IU/mL; of interest, 2 of the 6 (33.3%) were HBeAg-negative. Thirty-eight participants had HBV VL results at both mid-trimester and delivery. For these 38 participants, Wilcoxon signed-ranks test for paired data found that an HBV VL remained stable (p = .58). We observed no perinatal transmissions. However, 20.7% of infants did not have a documented complete HBV vaccination series, 20.0% did not have post-vaccination HBsAg testing completed, and 18% did not have anti-HBs titres measured by age 12 months. Our study demonstrates that HBeAg and HBV VL are not reliably predictive of each other. This supports the improved predictive value of VL measurement in pregnancy to risk stratify pregnant patients to offer antiviral treatment when indicated and further minimize the risk of perinatal transmission.

Computational fluid dynamics methods applied to intracranial stenosis imaging

Stenosis of the major intracranial arteries is an important cause of stroke, accounting for 8-10% of ischemic strokes in US. It was demonstrated that Computational Fluid Dynamics modelling may be a promising technique in evaluating and understanding the hemodynamic characteristics of ICAS lesions. It has not ever been evaluated if the results from CFD analysis of CTA and DSA source images correlate. This retrospective study evaluated 80 patients with symptomatic ICAS lesions treated at Tiantan Hospital in Beijing. The Vascular Modelling Toolkit software was used to generate 3D models from CTA source images. 3D reconstructions were generated from DSA images using Coronary3D software. Blood flow simulation was performed on both DSA and CTA generated meshes using ANSYS FLUENT SOLVER (ANSYS Inc.). A two-sample t test for paired data was used to compare the pressure and velocity measurements. CTA and DSA imaging were evaluated for 20 patients with symptomatic ICAS. Although faint signals and convoluted vasculature in 60 DSA scans prevented 3D reconstruction and excluded these cases from the study. When it was plotted the change in pressures of CTA versus the change in pressures of DSA R2 was 0.001; meaning that the linear model explains almost none of the variability in between the data in terms of changes in velocity and pressure. It was found no noticeable correlation between the information regarding pressure and velocity as given by DSA and by CTA. Therefore, we could not say that the information from DSA is on par with that of CTA.

Thickness of orthodontic clear aligners after thermoforming and after 10\u2009days of intraoral exposure: a prospective clinical study

BackgroundClear aligners (CA) are among the most chosen orthodontic therapies for patients who require an invisible treatment. Previous studies showed that the thermoforming process and the complexity of the intraoral environment might alter the properties of these devices. The aim of the current prospective clinical study was to assess the thickness changes of the CA after 10 days of intraoral use. The secondary aim was to assess the reproducibility of the thermoforming process, in terms of aligner thickness.Materials and methodsCA from 18 consecutive patients (13 women, 5 men, mean age 28.8 ± 9.6 years) were investigated. Before intraoral exposure (T0), the thickness of the unused CA was measured at different occlusal points on a 3D model with a dedicated software (Geomagic Qualify 2013; 3D Systems, Rock Hill, SC, USA). Two CA configurations were studied: passive maxillary aligner (P—no tooth movement; no shape for attachments) and active maxillary aligner (A—tooth movement; shape for attachments and divot). The used aligners were returned after 10 days (T1) and the thickness measurements were repeated. A Student’s t test for paired data (T1 vs. T0) was applied to compare the thicknesses of used and unused devices (significance level after Bonferroni correction for multiple comparison was set at p < 0.0014). Furthermore, to study the reproducibility of the thermoforming process, P and A aligners were thermoformed twice, and the thicknesses of the two unused thermoformed devices were compared by means of Student’s t test for paired data (significance level after Bonferroni correction for multiple comparison was set at p < 0.0014) and Dahlberg’s error.ResultsThe thermoforming process showed good reproducibility for both aligner configurations, with a maximum Dahlberg’s error of 0.13 mm. After intraoral use, the thickness of P showed some statistically significant, but not clinically relevant, thickness changes as compared to the unused aligners, while A did not show any significant changes.ConclusionConsidering the thickness changes, the thermoforming process is reliable both with active and passive aligner configurations. Also, the CA examined show good thickness stability after physiological intraoral ageing in a population of healthy adults.

Do Urban Minority Parents and Children Agree on Asthma Symptoms with Exercise, Worries, and Confidence in Disease Management?

ObjectiveProviders commonly rely on parent reports of a child's asthma symptoms; however, children as young as 7 years can report on their own health. Our study compared parent and child reports of asthma symptoms with exercise, worries about developing an asthma attack, and confidence in disease management. MethodsWe recruited children ages 7 to 10 years with asthma from 4 Bronx, NY, schools, as well as their parents. The parents and children completed interview surveys with parallel questions regarding perceived asthma symptoms, asthma-related worries, and confidence in disease management. We used McNemar tests for paired data to compare parent and child responses. ResultsWe analyzed data for 105 parent-child pairs. Mean child age was 8.5 years (standard deviation, 0.99); 53% were male, and 82% were Hispanic. Children were more likely than their parents to report ever having an exercise-induced asthma attack (85% vs 48%; P < .001) and that they “worry a lot” about developing an asthma attack during exercise (63% vs 45%; P = .01). Children felt more confident about using an inhaler correctly (76% of the children were “very sure” vs 60% of the parents; P = .009) and were more likely to report having an inhaler available in case of an attack (38% of the children were “very sure” vs 20% of the parents; P = .003). ConclusionsIn this school-based sample of urban children with asthma, we found disagreement between parent and child reports of symptoms with exercise, worry about developing an attack, and confidence in medication use. These findings suggest that including child reports during history taking could help providers identify children in need of enhanced asthma management.

Índice de masa corporal asociado a las características de las puérperas y de los neonatos

Introducción: Un Índice de Masa Corporal (IMC) pregestacional inadecuado conlleva riesgos maternos/fetales. Objetivos: Identificar el IMC pregestacional y vincularlo a los datos sociodemográficos y obstétricos de las puérperas; e identificar el IMC pregestacional y el aumento de peso durante el embarazo relacionados con las características de los neonatos. Materiales y Métodos: Estudio cuantitativo, descriptivo, desarrollado en un hospital de referencia, con 187 binomios. Los datos fueron recolectados a partir de la libreta prenatal y de la Declaración de Nacido Vivo. Debido a la ausencia de distribución gaussiana, se compararon las variables continuas, utilizando pruebas no paramétricas (Mann-Whitney o Kruskal-Wallis). Las muestras pareadas fueron comparadas utilizando la prueba de Wilcoxon para datos pareados. Para comparar las variables categóricas, se utilizó la prueba exacta de Fisher o la prueba chi-cuadrado de Pearson. Resultados: El IMC pre-gestacional varió de 16 a 53kg/m², promedio 25,0 ±5,9kg/m²; 41,2% con sobrepeso y mujeres obesas; el promedio de aumento del peso gestacional fue de 11Kg ±30Kg; el promedio de edad fue de 26 años. Se observó un aumento progresivo del peso de acuerdo con el aumento de la edad (P=0,009); las mujeres obesas más propensas a ser hospitalizadas por Síndrome Hiperintensiva Gestacional (P=0,003) y por hipertensión arterial crónica (P=0,026); entre las mujeres con IMC elevado 24,0% eran primíparas y 23,5% multíparas; el promedio de peso de los neonatos fue de 3146,8g ±559,7g. El peso de los neonatos de las obesas fue superior (P=0,034). Se observó una correlación positiva entre el IMC materno pre-gestacional y el peso del RN al nacer (rho–0,219; P=0,003). Discusión: Los resultados demostraron un aumento de peso en las madres gestantes, lo que corrobora las investigaciones de la literatura. Conclusiones: La evaluación del estado nutricional se debe realizar en la fase de planeación de la gestación con el fin de evitar complicaciones futuras.&#x0D; Como citar este artigo: Tresso BD, Tavares BB. Índice de massa corporal associado às caractéristicas das puérperas e dos neonatos. Rev Cuid. 2019; 10(2): e678. http://dx.doi.org/10.15649/cuidarte.v10i2.678

MON-190 Endo ECHO Improves Patient-Reported Measures of Access to Care, Health Care Quality, Self-Care Behaviors, and Overall Quality of Life for Patients with Complex Diabetes in Medically Underserved Areas of New Mexico

Background Individuals living with complex diabetes experience limited access to endocrine care due to a nationwide shortage of endocrinologists. Project ECHO (Extension for Community Healthcare Outcomes) is an innovative, scalable model of health care that extends specialty care to medically underserved areas through ongoing telementorship of community primary care providers (PCPs). The purpose of this study was to assess whether participation in the first iteration of the Endocrine ECHO (Endo ECHO) program resulted in changes to patient well-being, health behaviors and quality of care. Methods PCPs from 10 federally qualified health centers in NM participated in Endo ECHO, facilitated by a team of specialists at the University of New Mexico Health Sciences Center. Endo ECHO patients were eligible for the study if they were 18 years or older with “complex” diabetes: type 1 diabetes or type 2 diabetes and insulin dependent, and/or with an HbA1c of 9% or higher. Patients took a comprehensive survey during enrollment and again after one year. The Diabetes Comprehensive Care Clinic (DCCC) at UNM was included as a means of benchmarking specialized diabetes care, and a sample of DCCC patients completed surveys during the post-test time frame. We assessed ECHO patients for pre/post change using McNemar’s tests for paired data and then compared intervention group post-test scores to the DCCC patient scores. Results Five hundred thirty-three ECHO patients and completed pre and post surveys (62% response rate) and 139 DCCC patients completed surveys during the post survey period. At follow-up, 42% of ECHO patients reported their health status as excellent, very good or good at compared to 30% before program participation (p<0.0001), and 43% reported five or more days of physical activity per week, compared to 29% at baseline (p<0.0001). Endo ECHO patients reported more frequent provider-initiated tests for A1C (81% to 91%; p<0.0001), foot examinations (68% to 87%; p<0.0001), and eye exams (63% to 69%; p=0.0266), and 84% of patients felt confident in managing their blood sugar levels at follow-up compared to 62% at baseline (p<0.0001). Although Endo ECHO patients exhibited statistically significant improvements across all key measures at follow-up, they lagged behind DCCC patients in some areas, including positive health status (42% Endo ECHO post vs 68% DCCC), daily physical activity (43% ECHO post vs 50% DCCC) and daily blood sugar testing (70% ECHO post vs. 83% DCCC). Conclusions Endo ECHO appears to be effective means of improving the health and quality of life for patients with complex diabetes, although opportunities exist to further improve care as compared to care delivered at a university based specialty clinic. Endo ECHO may be a suitable alternative for patients in medically underserved communities where access to an endocrinology referral center is restricted.

Impact of an Online Training Program in Smoking Cessation Interventions in Hospitals.

To assess changes in the self-reported performance of smoking cessation interventions according to the 5A's model (Ask; Advise; Assess; Assist; and Arrange follow-up) among clinicians; and to identify the main barriers and facilitators in smoking cessation implementation before and after an online smoking cessation training program. Pre-post evaluation. We assessed self-reported smoking cessation interventions in the implementation of the 5A's model among clinicians working in Catalan hospitals (Spain). In addition, we assessed individual-, behavioral-, and organizational-level factors that act as barriers and facilitators in the implementation of the 5A's model. We used a questionnaire of 63 items reflecting each of the 5A's performance (scored from 0 = none to 10 = most possible). The questionnaire was completed both immediately before and 6 months after the training. We analyzed the data of those participants who had a clinical role and answered pre- and post-questionnaires. We used the nonparametric test for paired data (Wilcoxon) to examine changes in scores. A total of 127 clinicians completed the pre-post questionnaire; 63.0% were registered nurses, 17.3% were nursing assistants, 7.9% were physicians, and 11.8% were other professionals (p < .001). Overall, there were significant increases in the implementation of the assist component (from a score of 4.5 to 5.2; p < .003) and arrange a follow-up component (from 3.6 to 4.5; p < .001) of the intervention. Scores in the perception of the level of overall preparation, preparedness in using smoking cessation drugs, level of competence, and organizational recognition improved (p < .001) at the follow-up; however, the score in the perception that implementing smoking cessation is part of their job decreased (from 6.3 to 4.4; p < .001). The online training had a positive impact on the implementation of assist and arrange follow-up components. Although self-preparedness in the management of smokers increased, the motivation and involvement of key professionals decreased. Organizational factors related to the incorporation of resources (such as protocols, records, etc.) should be improved for the correct progression of smoking cessation interventions within the institutions. Smoking cessation training programs should incorporate some motivational content to increase the engagement of health professionals in smoking cessation interventions in their clinical practice.

Horizontal Bone Augmentation in the Anterior Esthetic Area of the Maxilla Using a Flap Design Adapted from Mucogingival Surgery in Association with PLA Membrane and β-TCP

Systematic reviews showed possible esthetic complications with the use of traditional flap designs after guided bone regeneration (GBR) procedures in the esthetic zone and the aim of this case series was to analyze hard and soft tissue changes over 18 months after these procedures. Healthy subjects requiring tooth extraction and single-implant placement in the anterior maxilla were enrolled in the study. Three months after tooth extraction and ridge preservation, a prosthetic-driven implant was placed. The horizontal bone deficiency was treated with a resorbable bone graft substitute (beta tricalcium phosphate [β-TCP]) and a bioresorbable polylactic acid (PLA) membrane. Primary closure was obtained by a novel coronally advanced flap adapted from mucogingival techniques. Final metal-free implant restorations were delivered 4 months after placement. Clinical measurements, pictures, and radiographs were acquired after delivery of the final restoration (T1) and at the 18-month follow-up (T2). Digital impressions were taken at the time of tooth extraction (T-1) and implant insertion (baseline; T0) and at T2. Marginal bone level changes were assessed by radiographic analysis, while soft tissue changes were evaluated with ExoCad software. Student t test for paired data was used to detect differences between the different time points. Twelve subjects (7 men and 5 women; mean age: 63.7 ± 14 years) completed the study and received 15 implants. All implants healed uneventfully and were clinically osseointegrated and stable, showing no sign of infection. No GBR complications were noted. Statistically significant ridge-width changes were observed after extraction (T-1 vs T0 = -1.72 ± 0.30 mm; P = .00001) and after horizontal GBR (T0 vs T2 = 1.41 ± 0.64 mm; P = .00001). Radiographic bone levels after implant placement remained stable T0 to T2 (0.09 ± 0.08 mm). Periodontal parameters never exceeded physiologic levels. It can be concluded that GBR using a bioresorbable PLA membrane and resorbable β-TCP bone graft in conjunction with a coronally advanced flap is a predictable procedure for horizontal bone augmentation with simultaneous implant placement in the esthetic area.

Evaluación de un modelo formativo para profesionales sanitarios en la atención del paciente crítico: Estudio AIPCAP

ObjectiveTo evaluate the validity, acceptability, and impact on the level of knowledge and skills of Primary Care health professionals of a training model aimed at improving the care of critical patients. DesignA quasi-experimental interventional, multicentre study. LocationEight health care teams in Barcelona. ParticipantsA total of 272 professionals. InterventionsA training program consisting of 48 simulations of acute myocardial infarction and stroke. Main measurementsA checklist was used to evaluate critical patient skills, effect of training on the knowledge of the participants, and a satisfaction survey. The training was carried out after 2 series of simulations (AMI+Stroke). In the second series, 3evaluations were made: in situ, one week after, and at 3weeks. Concordance and reliability were measured. The differences in means were analysed using the Student t test for paired data. ResultsA total of 449 knowledge tests were answered, with a higher score being obtained at the end of each simulation (3.89 -SD 1.01 vs. 3.21 -SD 1.09). Doctors obtained better medical scores than nurses (3.81 - SD 0.87 vs. 3.32 - SD 1.15), and professionals with a specialty completed scored more than those in training (MIR) (3.6 - SD 1.08 vs. 3.4 - SD 1.18).The mean score was 7.7 points (SD 1.56) in the first evaluation, and improved to 9.1 points (SD 0.78). The kappa index was greater than 0.40 in all cases. ConclusionsA training methodology in the management of emergencies in Primary Care based on simulations is valid, reliable and well accepted, achieving an improvement in the level of knowledge and skills of the participating professionals.

Computational fluid dynamics methods applied to intracranial stenosis imaging

Background Stenosis of the major intracranial arteries is an important cause of stroke, accounting for 8% to 10% of ischemic strokes in US. It was demonstrated that Computational Fluid Dynamics (CFD) modelling may be a promising technique in evaluating and understanding the hemodynamic characteristics of ICAS lesions. Previously, it has been shown that creating CFD models from routinely acquired computed tomographic angiography (CTA) and digital subtraction angiography (DSA) source images is feasible. However, it has not been evaluated if the results from CFD analysis of CTA and DSA source images correlate. Methods This retrospective study evaluated 80 patients with symptomatic ICAS lesions treated at Tiantan Hospital in Beijing. All patients had a symptomatic stenosis of the M1 segment of the middle cerebral artery (MCA-M1) with DSA and CTA imaging acquired at the time of treatment. The Vascular Modelling Toolkit software was used to generate 3D models from CTA source images. A region of interest containing the stenotic vessel was manually selected on the CTA source images, and then segmented using a gradient-driven level set method to generate an initial vessel volume. 3D reconstructions were generated from DSA images using Coronary3D software. The reconstructions were generated by using an anteroposterior and a lateral view of the stenotic vessel. Blood flow simulation was performed on both DSA and CTA generated meshes using ANSYS FLUENT SOLVER (ANSYS Inc.). A two-sample t test for paired data was used to compare the pressure and velocity measurements across imaging modalities. Results CTA and DSA imaging were evaluated for 20 patients with symptomatic ICAS. Although 3D reconstruction was possible for all 80 CTA scans, faint signals and convoluted vasculature in 60 of the 80 DSA scans prevented 3D reconstruction and excluded these cases from the study. When it was plotted the change in pressures of CTA versus the change in pressures of DSA, we received a R2 of 0.001; meaning that the linear model explains almost none of the variability in between the data in terms of changes in velocity and pressure. Conclusion It was found no noticeable correlation between the information regarding pressure and velocity as given by DSA and by CTA. Therefore, we could not say that the information from DSA is on par with that of CTA. Improvements in software that can robustly reconstruct DSA scans of brain vasculature is needed to computationally analyse a larger sample size of DSA data.

Gray Optic Disc Crescent: Evaluation of Anatomic Correlate by Spectral-Domain OCT

To test the hypothesis that the anatomic correlate of the gray optic disc crescent is pigmentation of externally oblique border tissue of Elschnig. Retrospective study. African-American adult men with or without clinically apparent gray optic disc crescents. McNemar's test for paired data and kappa statistic with 95% confidence intervals were used to examine the relationships between eyes with or without gray optic disc crescents and corresponding spectral-domain (SD) OCT images with enhanced depth imaging (EDI). Correlation between clinical gray optic disc crescents and hyperreflectivity of externally oblique border tissue of Elschnig by SD OCT with EDI. Twenty-five eyes had clinically apparent gray optic disc crescents, of which SD OCT with EDI revealed hyperreflectivity (interpreted as increased pigmentation) of externally oblique (obtuse angle) border tissue of Elschnig in 22 eyes, that is, extending into Bruch's membrane opening and presumably visible by funduscopy. Thirty-two eyes from matched participants had no apparent gray optic disc crescent, of which SD OCT with EDI revealed hyperreflectivity of the border tissue of Elschnig in 23 eyes, but with a nonoblique (right angle) or internal (acute angle) angle, which would presumably obstruct funduscopic visualization. Observations by SD OCT with EDI suggest that the anatomic correlate of the gray optic disccrescent is pigmentation of externally oblique border tissue of Elschnig.

Transcranial direct current stimulation (tDCS) over right temporoparietal junction (rTPJ) for social cognition and social skills in adults with autism spectrum disorder (ASD).

Social deficits are core to autism spectrum disorder (ASD). Current treatments are extremely time- and labor-intensive. Transcranial direct current stimulation (tDCS) may be a promising treatment modality to safely enhance treatments targeting social cognition and social skills. This pilot study investigates the effectiveness of social skills treatment interventions paired with anodal tDCS for six adults 18-58years with ASD. Differences were predicted on the verbal fluency (VF) test and a test of social skills (TASSK-M) for verum (2.0mA) vs. sham tDCS, which was randomly assigned in a within-subjects, double-blinded design in adults with ASD with normal or higher cognitive functioning. The anode electrode was placed over right temporoparietal (CP6) and cathode over ipsilateral deltoid. Wilcoxon signed-rank tests for paired data indicated that participants received a significantly higher score on the VF test after receiving verum tDCS compared to sham tDCS, with no significant differences found on the TASSK-M. Post-hoc analysis showed that the emotion-word portion of the VF test, specifically, indicated significant differences when comparing verum to sham tDCS conditions. These findings provide optimism for the use of tDCS as delivered in the current study paired with social skills treatment interventions for ASD, particularly for improving skills of emotion verbal fluency.

Stability of Periodontal Healing Distal to the Mandibular Second Molar After Third Molar Coronectomy: A 3-Year Follow-Up Study

The stability of the periodontal attachment distal to the mandibular secondmolar after coronectomy of the third molar is still unclear. This study addressed the question of whether periodontal measures are stable over time among patients undergoing coronectomy. This prospective cohort study enrolled 30 patients treated at the Unit of Oral and Maxillofacial Surgery of the University of Bologna. The predictor variables were the probing pocket depth (PPD), distance between the marginal crest and the bottom of the osseous defect (BOD), and distance between the cementoenamel junction and the BOD. Three points on the distal surface of the secondmolar were recorded: distobuccal, distomedial, and distolingual sites. The distobuccal site was used as the statistical unit. The Wilcoxon test for paired data and Kendall τb were used to evaluate all variables. The significance level was set at P<.05. The 3-year follow-up was completed by 27 patients (7 male and 20 female patients; mean age, 28±7years) with 30 third molars. At 3years, the PPD was 4±1.25mm; no significant changes in PPD were recorded for all sites from 9months to 3years. For the marginal crest-BOD distance and the cementoenamel junction-BOD distance, significant reductions were evident between preoperative values and those at 9 to 36months (P=.001) and between values at 9 and 36months (P=.02). A clinical healthy periodontium distal to the secondmolar was observed 36months after coronectomy. However, further studies are necessary to confirm these preliminary clinical results.

Association Between Unruptured Intracranial Aneurysms and Downstream Stroke.

Background and Purpose- Case reports suggest that unruptured intracranial aneurysms may serve as a nidus for thrombus formation and downstream embolic stroke. However, few data exist to support an association between unruptured aneurysms and ischemic stroke. Methods- We conducted a within-subjects case-control study of acute ischemic stroke patients prospectively enrolled in the Cornell Acute Stroke Academic Registry who had magnetic resonance imaging of the brain and arterial imaging of the head within 14 days of admission. Reviewers blinded to the study hypothesis ascertained the presence of aneurysms from the neuroradiologist's clinical report of the arterial imaging findings. McNemar test for paired data was used to compare the prevalence of unruptured aneurysms ipsilateral versus contralateral to the side of anterior circulation infarcts. Aneurysms of the anterior communicating artery or in the posterior circulation were not counted in the analysis. Results- Among 2116 patients registered in the Cornell Acute Stroke Academic Registry during 2011 to 2016, 1541 met our inclusion criteria, of whom 176 (11.4%; 95% CI, 9.8-13.0%) had an intracranial aneurysm. The prevalence of aneurysms did not differ on the side ipsilateral versus contralateral to the infarction (risk ratio [RR], 1.2; 95% CI, 0.9-1.5). There was no significant association between aneurysms and ipsilateral stroke in secondary analyses of the 1244 patients with stroke in a single anterior circulation territory (RR, 1.2; 95% CI, 0.8-1.9), the 619 patients with cryptogenic stroke (RR, 1.4; 95% CI, 0.9-2.0), or the 485 patients with cryptogenic stroke in a single anterior circulation territory (RR, 1.7; 95% CI, 0.8-3.3). Results were unchanged when counting only aneurysms >3 mm (RR, 1.2; 95% CI, 0.8-1.9) or 5 mm in diameter (RR, 1.2; 95% CI, 0.9-1.5). Conclusions- Contrary to our hypothesis, we found no significant association between unruptured intracranial aneurysms and ipsilateral ischemic stroke.