Background: Schizophrenia has far-reaching consequences for both – patients, and spouses as caregivers. Perception of caregiving and marital adjustment appears to depend on various factors and also on each other. Objective: To study caregiving experiences and marital adjustment in spouses of patients having schizophrenia. Materials and Methods: A cross-sectional study was done with spouses of 100 consecutive patients having schizophrenia in a tertiary care teaching institute. Scales used included Experience of caregiving inventory (ECI), Dyadic adjustment scale (DAS), Multidimensional scale of perceived social support (MSPSS) and Positive and negative syndrome scale (PANSS). Statistical analysis was done using SPSS-20 software using correlation, regression analysis, t-test and descriptive statistics as applicable. Results: Mean average of total positive score of ECI was higher (2.56) than a negative score; and for DAS, it was highest for consensus (3.07) and minimum for affect expression scale (1.66). Better dyadic adjustment (P-value