This research aims to estimate the expected economic losses associated with the repair cost of a set of code-compliant moment-resisting reinforced concrete buildings located on different soil conditions in Mexico City. The loss assessment methodology is based on the second generation of the Performance-Based Earthquake Engineering (PBEE) framework, which quantifies the seismic performance of buildings in terms of metrics such as economic losses, downtime, and casualties, which are more meaningful to owners and stakeholders for the decision-making process. The methodology uses a probabilistic approach that takes into account uncertainties in seismic intensity, structural response, component damage, and consequence prediction. The seismic response of structures was calculated in terms of inter-story drifts and floor accelerations to assess the damage to their structural and non-structural components. In addition, taking into account the seismic hazard of the site, the expected annual losses (EAL) are calculated to provide insight into the seismic performance evaluation of structures with different characteristics in terms of the financial impact in seismic-prone regions like Mexico City.