Pressure ulcers are defined as localized injuries to the skin and/or underlying tissue, usually over a bony prominence, as a result of pressure alone or in combination with shear. They commonly occur in patients with limited mobility, such as those in hospitals or long term care settings. It is estimated that up to 3 million adults in the United States are affected by pressure ulcers. The prevalence in the United States ranges from 0.4% to 38% in acute care hospitals. The estimated cost of treating each case of pressure ulcers ranges from $37,000 to $70,000 with up to $11 billion spent annually in the United States. Risk factors for pressure ulcers include older age, black race or Hispanic ethnicity, lower body weight, obesity, cognitive impairment, physical impairments and other comorbid conditions that affect soft tissue integrity and healing, such as urinary or fecal incontinence, lines and drains, diabetes, edema, impaired microcirculation, hypoalbuminemia, and malnutrition. Treatment of pressure ulcers involves multiple methods intended to alleviate the conditions contributing to ulcer development, including support surfaces, repositioning, nutritional support, protection of the wound from contamination and creation of a clean wound environment, promotion of tissue healing, debridement, wound cleansing, adjunctive therapies, and consideration for surgical repair.