In this paper, the modified Dirac equation (MDE) has been solved approximately for improved Manning–Rosen plus quasi-Hellman potentials (IMRQHPs), including the improved Yukawa tensor interaction under new spin symmetry and pseudospin symmetry for arbitrary spin–orbit number [Formula: see text], an appropriate approximation employed on the centrifugal terms in the symmetries of three-dimensional extended relativistic quantum mechanics (3D-ERQM). This potential is a superposition of Manning–Rosen plus quasi-Hellman potentials and some other exponential terms. Through the application of both new approximations to deal with the centrifugal term, Bopp’s shift method and the independent-time perturbation theory method, the recent modified approximate energy corrections under IMRQHPs are obtained for nuclei [Formula: see text]O and [Formula: see text]F and (O2, I2, N2, H2, LiH, CO and NO) diatomic molecules in 3D-ERQM and three-dimensional extended non-relativistic quantum mechanics (3D-ENRQM) symmetries. The recent values that we get appear sensitive to [Formula: see text], which are known as the discrete atomic quantum numbers, the mixed potential depths ([Formula: see text], [Formula: see text]) and [Formula: see text], the range of the potential [Formula: see text] and non-commutativity parameters [Formula: see text]. In both 3D-ERQM and 3D-ENRQM symmetries, we show that the recent corrections obtained on the new bound states under IMRQHPs are infinitesimal to the principal part of energy in the ordinary cases of 3D-RQM and 3D-NRQM symmetries. In the new symmetries of 3D-ERQM symmetries, it is not possible to get the exact analytical solutions [Formula: see text] and [Formula: see text], only the approximate solutions are possible. In addition, we discussed in detail the non-relativistic study of the studied mixed potentials. Four special cases, i.e. we investigated some special cases in the context of modified Schrödinger theories. In the framework of known relativistic quantum mechanics, we have clearly demonstrated that the modified Schrödinger equation can be represented as the Dirac equation under the influence of IMRQHPs.