The 18 September 2011 Sikkim Himalaya earthquake of Mw 6.9 (focal depth 50 km, NEIC report) with maximum intensity of VII on MM scale (www.usgs.gov) occurred in the Himalayan seismic belt (HSB), to the north of the main central thrust. Neither this thrust nor the plane of detachment envisaged in the HSB model, however, caused this strong devastating earthquake. The Engdahl–Hilst–Buland (EHB) relocated past earthquakes recorded during 1965–2007 and the available global centroid moment tensor) solutions are critically examined to identify the source zone and stress regime of the September 2011 earthquake. The depth section plot of these earthquakes shows that a deeper (10–50 km) vertical fault zone caused the main shock in the Sikkim Himalaya. The NW (North-West) and NE (North-East) trending transverse fault zones cutting across the eastern Himalaya are the source zones of the earthquakes. Stress inversion shows that the region is dominated by horizontal NNW-SSE (North of North-West-South of South-East) compressional stress and low angle or near horizontal ENE-WSW (East of North-East-West of South-West) tensional stress; this stress regime is conducive for strike-slip faulting earthquakes in Sikkim Himalaya and its vicinity. The Coulomb stress transfer analysis indicates positive values of Coulomb stress change for failure in the intersecting deeper fault zone that produced the four immediate felt aftershocks (M ≥ 4.0).