Vortex-induced motion (VIM) of a tension leg platform (TLP) is critical to avoid structural and fatigue damages to the tendons and risers. Many previous studies have conducted model tests for TLPs in towing tanks. However, the models were usually established using linear springs to replicate the underwater moorings. In this study, a TLP model with full-water-depth tendons and top tension risers (TTRs) was developed. A series of model tests were conducted in a large-scale wave tank at three incidence angles (θ=0°, 22.5°, and 45°) for the reduced velocity ranging from 4 to 11.5 and two extra cases of flow combined with irregular waves. The maximum transverse amplitude of 0.32D was observed at a reduced velocity of 7.0 when θ=0°. On the other hand, the in-line and yaw motion experienced increasing amplitudes with reduced velocities and no lock-in region was identified. The most significant responses of transverse and yaw motion appeared at 0° and 22.5° headings, respectively, while no critical heading was recognized for surge motion. The competing mechanics between VIM and the wave-induced motion were revealed in the cases of combined flows and irregular waves. The tensions in tendons and TTRs that result from VIM were found as significant as those induced by wave loads, which highlights the necessity of considering VIM in the design of TLP. Furthermore, the result showed that the VIM amplitudes were considerably suppressed under the nonlinear stiffness and larger damping provided by the tendons and TTRs.