In response to global environment and fuel efficiency regulations aiming to reduce CO2 emissions, multi-material structures that use lightweight materials are currently being developed to realize the weight reduction of vehicles in automotive manufacturing. The dissimilar welding of aluminum alloy to steel has great importance, but it is still challenging due to their widely varying thermo-physical properties and the formation of intermetallic compounds. This study aimed to investigate the effect of process parameters on the wettability, mechanical properties, and microstructure in AC Pulse MIG welded joints of AA6061-T6 and galvanized steel sheets. A parametric study on torch aiming position and welding current with EN ratio variation was performed to optimize the process parameters. The result showed that the amount of metal deposition increased with EN ratio. When the EN ratio was higher, the wire feeding speed increased and the heat input process lowered. Moreover, the wetting length increased, ranging from 6.6 to 8.4 mm, and the wetting angle increased from 31.2 to 67.6°, respectively. As a result of the tensile shear test, the maximum tensile shear load of dissimilar welded joints produced at 70 A with a 20% EN ratio was approximately 8.8 kN. From the result of scanning electron microscopy with energy-dispersive spectrometry, FeAl3 IMC was observed at the joint interface, and the IMC layer thickness decreased with EN ratio at 70 A.