The objective of the research was to determine the exact process parameters required for spot-welding AA2014 and AISI316 alloys. The main focus was on achieving particular welding results, including nugget diameter, hardness, and tensile shear fracture load (TSFL). The central composite rotatable design model within the framework of a Response Surface Methodology (RSM) optimization approach, the study sought to intensify key spot weld process factors. The mechanical characteristics and nugget diameter of the welded joints were analyzed by carefully examining these factors to determine their significant effects. The investigation yielded crucial insights, revealing that the highest strength of welded joints, characterized by a nugget diameter of 5.982 mm, hardness of 149.6 VHN, and TSFL of 2.355 KN, was achieved at 3.4 kgf, when accompanied by 60 W power and a 2.5s duration. Notably, power emerged as the predominant factor driving the spot-welding process. Furthermore, microhardness and TSFL displayed direct correlations with power, while nugget diameter exhibited an inverse relationship. Moreover, rigorous statistical analyses, including F-tests and ANOVA, provided robust validation, indicating that the observed values fell comfortably within a 99.5% confidence interval for hardness, nugget diameter, and TSFL. These meticulously derived conclusions represent a significant stride towards establishing more standardized and efficient spot-welding protocols, particularly beneficial for the manufacturing sectors dealing with mild steel and aluminium materials.