In order to explore the fatigue damage mechanism of CRME under dynamic load, DEM of CRME was established based on PFC2D. The micromechanical response characteristics of CRME were obtained by simulation splitting test, and verified by indoor indirect tensile fatigue test. It shows that the results of simulation test are basically consistent with those of indoor test. The numerical value and quantity of tensile force chain in DEM increase obviously with the increase of the stress ratio, the fatigue life decays rapidly, and the horizontal displacement at different width positions in the specimen increases significantly. The tensile force chain is generated, accumulated and concentrated in the mortar and the aggregate-mortar interface. Eventually, the micro structure and bonding force of CRME are damaged. Tensile force chain is the main factor of fatigue damage. The improvement of the bonding performance of bitumen emulsion cement mortar (BECM) and RAP-mortar interface is suggested to improve the fatigue performance of CRME.