Medicinal herbs or extracts of herbs have been used widely by the public. The World Health Organization (WHO) has also approved the use of herbal medicines for some diseases, including diabetes mellitus. Fruit of rimbang (Solanum torvum Swartz) and rhizome of temulawak (Curcuma xanthorriza Roxb) arematerials traditionally used in the treatment of diabetes and hyperlipidemia. A number of studies had also been conducted to prove the efficacy of the two plants separately. This study was done to investigate in vivo activity of the combination of plant extracts as antidiabetic and antidyslipidemia. Animals were grouped into 7 groups consisting of normal group, diabetescontrol, diabetes treated with extract ofrimbang (400 mg/kg), diabetes treated with extract of temulawak (400 mg/kg), diabetes treated with a combination of extracts comprising rimbang and temulawak extract each in the same amount (400 mg/kg), diabetes treated with reference antidiabetes glibenclamide (5 mg/kg), and diabetes treated with referenceantihyperlipidemia simvastatin (4 mg/kg). The state of diabetes in mice was induced by intravenousinjection of alloxan (65 mg/kg). Mice whose blood glucose levels reach 250-350 mg/dl were included in the study (day 0). Extract, combination of extract and the reference drug were given orally for 21 days. Measurement of blood glucose levels were done on 7th, 14th, and 21stday. While measurements of HDL, LDL, and triglycerideslevels were performed on 21stday. The results showed that the combination of extracts comprising half doses of each extract could lower blood glucose levels significantly (P<0.05) with the same efficacy to each single extract. The combination of the extract was also able to significantly improve blood lipid profile (P<0.05) even with better efficacy than each single extract.