The Yangtze River Delta is one of the most economically developed regions on the eastern coast of China. However, a local imbalance currently exists between its water resource environment and economic and social development due to its rapid urbanization. Thus, the reasonable evaluation and protection of local water resources are necessary. This study explores the northern Yangtze Delta, which is a more developed water system, as a pilot area. The temporal and spatial variation characteristics of rainfall and evaporation and their influencing factors were analyzed on the basis of 29 surface water sampling points, 16 rainfall stations, and three evaporation stations in the field from 1956 to 2019. Accordingly, the overall water supply quality of the river basin, the availability of different water resources, and the application of evaluation methods were assessed. Results show that local precipitation and evaporation are characterized by uneven spatial and temporal distributions in local areas, which, in turn, leads to the uneven temporal distribution of runoff, increasing the imbalance between the availability and demand of the limited local water resources. Nevertheless, the overall performance of local water quality is good. Surface water quality is mostly Ⅱ to Ⅲ, and locally Ⅳ. Most noncompliant months are during the non-flood season, and all values exceed the standard permanganate index. Groundwater is Class III or better, and the hydrochemistry type is predominantly calcium bicarbonate, sodium bicarbonate, and magnesium bicarbonate. By exploring the evaluation model of the Yangtze River Delta watershed characteristics, this study aims to provide a helpful reference for extending water resource evaluation in the Yangtze River Delta. Accordingly, this study can promote the sustainable development of the economic and social sectors of the Yangtze River Delta and the construction of its ecological environment.