Event Abstract Back to Event Habituation and dis-habituation to changes in stimulus identity and location in the auditory system of awake, behaving songbirds. Tom V. Smulders1, 2* and Erich Jarvis3 1 Newcastle University, Institute of Neuroscience (IoN), United Kingdom 2 Duke University Medical Center, Department of Neurobiology, United States 3 Howard Hughes Medical Institute, Department of Neurobiology, United States Repeated exposure to an auditory stimulus leads to habituation of the electrophysiological and immediate-early-gene (IEG) expression response in the auditory system. A novel auditory stimulus reinstates this response in a form of dis-habituation (Chew et al. 1995). This has been interpreted as the start of new memory formation for this novel stimulus. Changes in the location of an otherwise identical auditory stimulus can also dis-habituate the IEG expression response (Kruse et al. 2004). In this study, we ask whether this dis-habituation should be interpreted as new neuronal memory formation for an auditory object that includes spatial location. To answer this question, we used a chronic multi-electrode array to record multi-unit activity from the auditory system of awake and behaving female zebra finches. For the first time in awake behaving birds, we found habituation to repeated exposure to the same song and dis-habituation with a novel song, similar to that described in head-fixed restrained animals. In addition, a large proportion of recording sites showed dis-habituation when the same auditory stimulus was moved to a novel location. However, when the song was randomly moved among 8 interleaved locations, habituation occurred independently from the continuous changes in location. When 8 different stimuli were interleaved all from the same location, habituation occurred to each stimulus separately. To explain these seemingly contradictory findings in auditory stimulus identity and location, depending on single or interleaved stimulus groupings, we propose an “oddball stimulus hypothesis”, whereby the auditory system may be engaged by attention systems to unexpected changes to auditory stimulus identity or temporal-spatial context. Acknowledgements TVS was partially supported by an institutional NRSA post-doctoral training grant held in the Department of Neurobiology at Duke University Medical Center. The work was funded by a David and Lucille Packard Foundation Award, and a NSF & NIH CRCNS R01-DC007996 from NIDCD to EDJ. References Chew SJ, Mello C, Nottebohm F, Jarvis E, and Vicario DS. Decrements in auditory responses to a repeated conspecific song are long-lasting and require two periods of protein synthesis in the songbird forebrain. Proc Natl Acad Sci U S A 92: 3406-3410, 1995. Kruse AA, Stripling R, and Clayton DF. Context-specific habituation of the zenk gene response to song in adult zebra finches. Neurobiol Learn Memory 82: 99-108, 2004. Keywords: oddball detection, spatial location, stimulus-specific adaptation, Taeniopygia guttata, Zebra finch Conference: Tenth International Congress of Neuroethology, College Park. Maryland USA, United States, 5 Aug - 10 Aug, 2012. Presentation Type: Poster (but consider for Participant Symposium) Topic: Sensory: Audition Citation: Smulders TV and Jarvis E (2012). Habituation and dis-habituation to changes in stimulus identity and location in the auditory system of awake, behaving songbirds.. Conference Abstract: Tenth International Congress of Neuroethology. doi: 10.3389/conf.fnbeh.2012.27.00212 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Apr 2012; Published Online: 07 Jul 2012. * Correspondence: Dr. Tom V Smulders, Newcastle University, Institute of Neuroscience (IoN), Newcastle upon Tyne, NE2 4HH, United Kingdom, tom.smulders@ncl.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. 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