The aim of the study is to consider and show the possibilities of methods for surgery of skull base tumors using the example of successful surgical treatment of a patient with widespread trigeminal neuroma located in the posterior, middle and temporal fossae, as well as to analyze international scientific experience on this issue.
 Materials and methods. In February 2020, a 60-year-old patient with widespread trigeminal neuroma on the left was admitted to the Federal Scientific-Clinical Center of FMBA of Russia in February 2020. After additional examination and preoperative preparation, a planned operation was performed - osteoplastic orbitozygomatic trepanation of the skull, microsurgical removal of the tumor through subtemporal transcavernous access. A good postoperative clinical result was obtained. An analysis of the available scientific literature on this problem is carried out.
 Results. In the postoperative period, pain and neurological symptoms, hemifacial spasm completely regressed. 1.5 months after the operation, the tumor was totally removed in the control images. In the course of the analysis of available foreign and domestic literature, 65 observations of trigeminal tumors with extracranial growth were found, the total removal of which was performed only in 20% of patients.
 Conclusion. Despite the extreme complexity of the pathology, the operation through the orbitozygomatic subtemporal transcavernous access allows you to completely remove the common and giant trigeminal neuromas with a good functional result.
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