Temporal Disconnection Research Articles

Early oxytocin inhibition of salt intake after furosemide treatment in rats?

Body fluid homeostasis requires a complex suite of physiological and behavioral processes. Understanding of the role of the central nervous system (CNS) in integrating these processes has been advanced by research employing immunohistochemical techniques to assess responses to a variety of body fluid challenges. Such techniques have revealed sex/estrogen differences in CNS activation in response to hypotension and hypernatremia. In contrast, it has been difficult to conclusively identify specific CNS areas and neurotransmitter systems that are activated by hyponatremia using these techniques. In part, this difficulty is due to the temporal disconnect between the physiological effects of treatments commonly used to deplete body sodium and the behavioral response to such depletion. In some methods, sodium ingestion is delayed in association with increased oxytocin (OT), suggesting an inhibitory role for OT in sodium intake. Urinary sodium loss increases within an hour after treatment with furosemide, a natriuretic-diuretic, but sodium intake is delayed for 18–24h. Accordingly, we hypothesized that acute furosemide-induced sodium loss activates centrally-projecting OT neurons which provide an initial inhibition of sodium intake, and tested this hypothesis in ovariectomized Sprague-Dawley rats with or without estrogen using immunohistochemical methods. Neuronal activation in the hypothalamic paraventricular nuclei (PVN) after administration of furosemide corresponded to the timing of the physiological effects. The activation was not different in estrogen-treated rats, nor did estrogen alter the initial suppression of sodium intake. However, virtually no fos immunoreactive (fos-IR) neurons in the parvocellular PVN were also immunolabeled for OT. Thus, acute sodium loss after furosemide produces neural activation and an early inhibition of sodium intake that does not appear to involve activation of centrally-projecting OT neurons and is not influenced by estrogen.

Design and implementation of instructional videos for upper-division undergraduate laboratory courses

Well-designed laboratories can help students master content and science practices by successfully completing the laboratory experiments. Upper-division chemistry laboratory courses often present special challenges for instruction due to the instrument intensive nature of the experiments. To address these challenges, particularly those associated with rotation style course structures, pre-laboratory videos were generated for two upper-division laboratory courses, Analytical Measurements and Physical Measurements. Sets of videos were developed for each experiment: a pre-laboratory lecture, an experimental, and a data analysis video. We describe the theoretical principles that guided the design of the instructional videos as well as the process. To assess the impact of the videos on students' successful completion of the experiments, a mixed-methods approach to data collection was used, which included video-recorded laboratory observations, student one-on-one interviews, and the Meaningful Learning in the Laboratory Inventory (MLLI) survey. Our findings indicate that video-based resources can help alleviate some challenges associated with rotation-style labs, particularly the temporal disconnect between pre-laboratory lectures and experiment completion as well as the need for more student autonomy in upper-division laboratory courses.

PECEVA: An adaptable and energy-saving credential validation solution for pervasive networks

Wireless, mobile, and context-awareness applications are considered to be the epitome of pervasive computing, but they bring with them the inherent security challenges of mobile ad-hoc networking. Mobile ad-hoc networks are mainly formed by mobile users, which can belong to different trust domains, in order to leverage the wealth of pervasive resources and available capabilities. The use of digital certificates is suitable for pervasive networking because of its decentralized and dynamic nature. Nevertheless, the validation of such certificates can become a more complex and costly process than it is in fixed-infrastructure networks. This is because pervasive networks face challenges such as environments that change with a certain degree of randomness, ad-hoc interactions with foreign devices, temporal disconnections that make it difficult to access updated and required information, and limited devices running costly processes. For these reasons, we propose a user-centric architecture that extends the validation of digital certificates in an adaptive way. The main contribution consists of a decision engine that takes advantage of the specific local and external resources in an opportunistic fashion. The solution preserves the security level required for each application and the resource consumption of the user device.

Ecosystem monitoring for ecosystem‐based management: using a polycentric approach to balance information trade‐offs

Ecosystem monitoring for ecosystem‐based management: using a polycentric approach to balance information trade‐offs

Submerged shoreline preservation and ravinement during rapid postglacial sea-level rise and subsequent “slowstand”

Submerged shorelines hold much potential for examining the interplay between the rate of sea-level rise and geomorphic setting, and informing the development of models of contemporary shoreline behavior. This paper describes the sedimentary architecture of a submerged barrier shoreline complex off Durban, South Africa. The complex consists of several barriers that have survived the postglacial transgression and associated erosive ravinement processes. The main shoreline sequence (–60 m) dates to 11,690 ± 90 calibrated (cal) yr B.P. and rests on a Pleistocene lagoonal deposit (35,395 ± 592 cal yr B.P.). The entire barrier shoreline complex is truncated by a strongly diachronous wave ravinement surface. The ravinement surface seaward of the main –60 m shoreline is steep, but the gradient declines across and landward of the subordinate landward shoreline complexes. The steep ravinement surface is attributed to fast sea-level rise (possibly associated with meltwater pulse 1B), while the gentle ravinement surface is associated with a subsequent slowing of the rate of sea-level rise (to 0.15 mm yr –1 ). Preservation of the main barrier and back-barrier deposits through overstepping is associated namely with rapid transgression and increased back-barrier accommodation. The smaller barriers landward of the main barrier were preserved through overstepping related to gentle antecedent gradients, despite more intense ravinement during a very slow rise in sea level (slowstand). This process was assisted by a sediment deficit. The resulting post-transgressive drape is also influenced by antecedent topography created by the barriers themselves; damming along the landward sides of overstepped barriers thickens the drape and creates a temporal disconnect between the migration of the shoreface and more landward elements of the littoral system. In examining the rates of shoreline migration associated with the overstepped barrier system, these are far greater than those calculated for the predicted rates of shoreline change on similarly steep coastal profiles. Future rates of shoreline migration appear to be insufficient to cause overstepping, and rollover or erosional responses are more likely.

Pointcatcher software: analysis of glacial time-lapse photography and integration with multitemporal digital elevation models

ABSTRACTTerrestrial time-lapse photography offers insight into glacial processes through high spatial and temporal resolution imagery. However, oblique camera views complicate measurement in geographic coordinates, and lead to reliance on specific imaging geometries or simplifying assumptions for calculating parameters such as ice velocity. We develop a novel approach that integrates time-lapse imagery with multitemporal DEMs to derive full three-dimensional coordinates for natural features tracked throughout a monoscopic image sequence. This enables daily independent measurement of horizontal (ice flow) and vertical (ice melt) velocities. By combining two terrestrial laser scanner surveys with a 73 days sequence from Sólheimajökull, Iceland, variations in horizontal ice velocity of ~10% were identified over timescales of ~25 days. An overall decrease of ~3.0 m surface elevation showed asynchronous rate changes with the horizontal velocity variations, demonstrating a temporal disconnect between the processes of ice surface lowering and mechanisms of glacier movement. Our software, ‘Pointcatcher’, is freely available for user-friendly interactive processing of general time-lapse sequences and includes Monte Carlo error analysis and uncertainty in projection onto DEM surfaces. It is particularly suited for analysis of challenging oblique glacial imagery, and we discuss good features to track, both for correction of camera motion and for deriving ice velocities.

Exhausted Futures

This experimental photo essay responds to a growing foreboding that the future has been occupied, colonized, or destroyed. It is a methodological experiment with attunement and futurity, aiming not to reattune to authentic forms of temporality or to rediscover lost forms of imagination and memory, but to make creative use of our temporal misattunements and disconnections. Drawing on research in a postindustrial neighbourhood of Cardiff, the essay dwells on the new temporalities that might emerge from an inertia of time.

Toward the Adaptation of Routine Activity and Lifestyle Exposure Theories to Account for Cyber Abuse Victimization

With the advent of the Internet and the emergence of cybercrimes (e.g., cyber stalking, cyber harassment), criminologists have begun to explore the empirical utility of lifestyle exposure and routine activity theories (RATs) to account for personal victimization as a consequence of cyber abuse. Available cyber abuse studies have produced inconsistent empirical support for both models, which has reignited the debate about whether terrestrial theories, such as RAT, will ever be able to adequately explain cybercrimes due to the spatial and temporal disconnect between the theories and the cyber environment. This article reviews existing cyber abuse scholarship, explores potential reasons for the weak empirical support for routine activity and lifestyle exposure theories in cyberspace, and proposes several directions for future research. We suggest that to further our understanding of cyber abuse processes, scholars need to carefully define and operationalize the key theoretical concepts in the light of latest developments in RAT (i.e., addition of new controllers—handlers and place managers, and super controllers), and conduct in-depth qualitative studies, as well as quantitative studies, that employ robust methodological designs and multi-level statistical analyses.

Temporal plus epilepsy is a major determinant of temporal lobe surgery failures.

Reasons for failed temporal lobe epilepsy surgery remain unclear. Temporal plus epilepsy, characterized by a primary temporal lobe epileptogenic zone extending to neighboured regions, might account for a yet unknown proportion of these failures. In this study all patients from two epilepsy surgery programmes who fulfilled the following criteria were included: (i) operated from an anterior temporal lobectomy or disconnection between January 1990 and December 2001; (ii) magnetic resonance imaging normal or showing signs of hippocampal sclerosis; and (iii) postoperative follow-up ≥ 24 months for seizure-free patients. Patients were classified as suffering from unilateral temporal lobe epilepsy, bitemporal epilepsy or temporal plus epilepsy based on available presurgical data. Kaplan-Meier survival analysis was used to calculate the probability of seizure freedom over time. Predictors of seizure recurrence were investigated using Cox proportional hazards model. Of 168 patients included, 108 (63.7%) underwent stereoelectroencephalography, 131 (78%) had hippocampal sclerosis, 149 suffered from unilateral temporal lobe epilepsy (88.7%), one from bitemporal epilepsy (0.6%) and 18 (10.7%) from temporal plus epilepsy. The probability of Engel class I outcome at 10 years of follow-up was 67.3% (95% CI: 63.4-71.2) for the entire cohort, 74.5% (95% CI: 70.6-78.4) for unilateral temporal lobe epilepsy, and 14.8% (95% CI: 5.9-23.7) for temporal plus epilepsy. Multivariate analyses demonstrated four predictors of seizure relapse: temporal plus epilepsy (P < 0.001), postoperative hippocampal remnant (P = 0.001), past history of traumatic or infectious brain insult (P = 0.022), and secondary generalized tonic-clonic seizures (P = 0.023). Risk of temporal lobe surgery failure was 5.06 (95% CI: 2.36-10.382) greater in patients with temporal plus epilepsy than in those with unilateral temporal lobe epilepsy. Temporal plus epilepsy represents a hitherto unrecognized prominent cause of temporal lobe surgery failures. In patients with temporal plus epilepsy, anterior temporal lobectomy appears very unlikely to control seizures and should not be advised. Whether larger resection of temporal plus epileptogenic zones offers greater chance of seizure freedom remains to be investigated.

Landscape genetics in a changing world: disentangling historical and contemporary influences and inferring change.

Landscape genetics seeks to determine the effect of landscape features on gene flow and genetic structure. Often, such analyses are intended to inform conservation and management. However, depending on the many factors that influence the time to reach equilibrium, genetic structure may more strongly represent past rather than contemporary landscapes. This well-known lag between current demographic processes and population genetic structure often makes it challenging to interpret how contemporary landscapes and anthropogenic activity shape gene flow. Here, we review the theoretical framework for factors that influence time lags, summarize approaches to address this temporal disconnect in landscape genetic studies, and evaluate ways to make inferences about landscape change and its effects on species using genetic data alone or in combination with other data. Those approaches include comparing correlation of genetic structure with historical versus contemporary landscapes, using molecular markers with different rates of evolution, contrasting metrics of genetic structure and gene flow that reflect population genetic processes operating at different temporal scales, comparing historical and contemporary samples, combining genetic data with contemporary estimates of species distribution or movement, and controlling for phylogeographic history. We recommend using simulated data sets to explore time lags in genetic structure, and argue that time lags should be explicitly considered both when designing and interpreting landscape genetic studies. We conclude that the time lag problem can be exploited to strengthen inferences about recent landscape changes and to establish conservation baselines, particularly when genetic data are combined with other data.

Overcoming the Knowledge Problem in Behavioral Law and Economics: Uncertainty, Decision Theory, and Autonomy

Science evolves in the long run. Law rules in the present. This potential temporal disconnect leads to a Hayekian “knowledge problem”, a challenge increasingly raised against behavioral law and economics: Empirical findings are deemed too uncertain to provide a solid basis for legal reasoning. This paper claims that in such cases, rules for decision making under risk and uncertainty have to enter the game. They can serve as analytic tools and generate positive solutions to the knowledge problem, thereby ensuring a rational treatment of the question of bounded rationality. The paper thus essentially applies a meta-decision theory to the question of what kind of decision theory (rational choice or behavioral decision theory) should govern legal reasoning. Generally, two routes may be pursued: First, in some situations it is possible to reduce uncertainty with the help of advanced empirical techniques. This prepares the ground for decision making under risk in an expected utility analysis. Second, in the majority of cases, reliable empirical data are indeed so far unavailable, necessitating decision making under uncertainty. In a decision theoretic maximin analysis, this paper demonstrates that in these cases of empirically unresolved uncertainty legal rules should presumptively assume the significant presence of bounded rationality among the relevant actors. The result can be successfully defended against the common objection that behaviorally informed interventions, such as debiasing or nudging, constitute an infringement of autonomy. Finally, implications of this methodologically novel justification of behaviorally informed legislation and adjudication for specific legal concepts in consumer law and product liability are discussed.

Ignimbrites to batholiths: Integrating perspectives from geological, geophysical, and geochronological data

Multistage histories of incremental accumulation, fractionation, and solidification during construction of large subvolcanic magma bodies that remained sufficiently liquid to erupt are recorded by Tertiary ignimbrites, source calderas, and granitoid intrusions associated with large gravity lows at the Southern Rocky Mountain volcanic field (SRMVF). Geophysical data combined with geological constraints and comparisons with tilted plutons and magmatic-arc sections elsewhere are consistent with the presence of vertically extensive (>20 km) intermediate to silicic batholiths (with intrusive:extrusive ratios of 10:1 or greater) beneath the major SRMVF volcanic loci (Sawatch, San Juan, Questa-Latir). Isotopic data require involvement of voluminous mantle-derived mafic magmas on a scale equal to or greater than that of the intermediate to silicic volcanic and plutonic rocks. Early waxing-stage intrusions (35–30 Ma) that fed intermediate-composition central volcanoes of the San Juan locus are more widespread than the geophysically defined batholith; these likely heated and processed the crust, preparatory for ignimbrite volcanism (32–27 Ma) and large-scale upper-crustal batholith growth. Age and compositional similarities indicate that SRMVF ignimbrites and granitic intrusions are closely related, but the extent to which the plutons record remnants of former magma reservoirs that lost melt to volcanic eruptions has been controversial. Published Ar/Ar-feldspar and U-Pb-zircon ages for plutons spatially associated with ignimbrite calderas document final crystallization of granitoid intrusions at times indistinguishable from the tuff to ages several million years younger. These ages also show that SRMVF caldera-related intrusions cooled and solidified soon after zircon crystallization, as magma supply waned. Some researchers interpret these results as recording pluton assembly in small increments that crystallized rapidly, leading to temporal disconnects between ignimbrite eruption and intrusion growth. Alternatively, crystallization ages of the granitic rocks are here inferred to record late solidification, after protracted open-system evolution involving voluminous mantle input, lengthy residence (105–106 yr) as near-solidus crystal mush, and intermittent separation of liquid to supply volcanic eruptions. The compositions of the least-evolved ignimbrite magmas tend to merge with those of caldera-related plutons, suggesting that the plutons record nonerupted parts of long-lived cogenetic magmatic systems, variably modified prior to final solidification. Precambrian-source zircons are scarce in caldera plutons, in contrast to their abundance in some peripheral waning-stage intrusions of the SRMVF, implying dissolution of inherited crustal zircon during lengthy magma assembly for the ignimbrite eruptions and construction of a subvolcanic batholith. Broad age spans of zircons (to several million years) from individual samples of some ignimbrites and intrusions, commonly averaged and interpreted as “intrusion-emplacement age,” alternatively provide an incomplete record of intermittent crystallization during protracted incremental magma-body assembly, with final solidification only when the system began to wane. Analyses of whole zircons cannot resolve late stages of crystal growth, and early growth in a long-lived magmatic system may be poorly recorded due to periods of zircon dissolution. Overall, construction of a batholith can take longer than recorded by zircon-crystallization ages, while the time interval for separation and shallow assembly of eruptible magma may be much shorter. Magma-supply estimates (from ages and volcano-plutonic volumes) yield focused intrusion-assembly rates sufficient to generate ignimbrite-scale volumes of eruptible magma, based on published thermal models. Mid-Tertiary processes of batholith assembly associated with the SRMVF caused drastic chemical and physical reconstruction of the entire lithosphere, probably accompanied by asthenospheric input.

Impact of intraoperative MRI on outcomes in epilepsy surgery: preliminary experience of two years

Purpose. To determine the impact of intraoperative magnetic resonance imaging (iMRI) in epilepsy surgeries on the extent of surgical resection and seizure outcome along with its feasibility and limitations. Methods. Patients with pharmacoresistant epilepsy (PRE), who underwent surgeries in operating theater equipped with high-field 1.5-Tesla MRI, were evaluated for extent of resection, operative time, scanning time, pathologies, resultant extra resection, and seizure outcomes. Results. Thirty-nine patients with mean age of 18 (range: 3–65) years with PRE underwent surgical intervention. Mean duration of epilepsy was 10.2 years. Surgical interventions included tumor resection (31%), resection of focal cortical dysplasia (28%), mesial temporal lobe surgeries (18%), and disconnection surgeries (23%). iMRI alone, apart from navigation and electrophysiology, improved resection rates in 13% (5 out of 39) of these patients. In lesional group, iMRI modified operative strategy resulting in increased resections in 21% (5/23) patients. Complete resection was observed in 87% of patients. iMRI scanning time constituted 25% (mean: 72 ± 21 min) of time spent under anesthesia by the patient. Major and minor complications were observed in 2.5% and 7.5% of patients, respectively. The mean follow-up was 14 months. Favorable postoperative seizure control (Engel Classes I and II) was achieved in 85% and complete seizure freedom was achieved in 77% of patients (Engel Class IA) at 1-year follow-up. Conclusions. iMRI increases the extent of resection mainly in lesional epilepsy surgeries translating into good seizure outcomes but not found to be much beneficial in prototype mesial temporal sclerosis surgeries and disconnection surgeries.

Interaction in the artistic knowledge creation process: The case of artists in Finnish Lapland

This paper contributes to the need in economic geography to understand temporal interactions and sources of new knowledge in such interactions in the knowledge creation process. The focus is on eleven international artists who live in peripheral locations in Finnish Lapland, where spatial and temporal disconnections easily evolve. The paper considers the meaning of such disconnections, as well as human–object interaction. The processes are analysed through the spatio-temporal framework of object, communicative and cognitive spaces, and linear and relational times.The empirical research into knowledge creation in economic geography lacks views of peripheries, artistic knowledge and the consideration of the process in the ‘here and now’. These views are needed to meet the challenge of understanding knowledge creation processes in various fields and contexts. The main materials of this ethnographic case study – interviews, observation and videotaping of the artists working – are analysed using content analysis.The results show the central position of objects in interactions of artistic knowledge creation. The two main modes of temporal interactions are (re)searching and (dis)connecting. In the early stages, continuous and wide (re)searching includes returning in time that addresses the framework for developing artwork. The artists living in peripheries benefit from disconnections based on geographical isolation. The moments of (dis)connections between the field and artist, object-cognitive spaces and dimensions of time are sources of new knowledge. Some connections might prevent knowledge creation. Therefore, objects, temporality and the cognitive space of interpreted messages are important to acknowledge when studying interactive knowledge creation.

Benthic perspective on Earth’s oldest evidence for oxygenic photosynthesis

The Great Oxidation Event (GOE) is currently viewed as a protracted process during which atmospheric oxygen increased above ∼10(-5) times the present atmospheric level (PAL). This threshold represents an estimated upper limit for sulfur isotope mass-independent fractionation (S-MIF), an Archean signature of atmospheric anoxia that begins to disappear from the rock record at 2.45 Ga. However, an increasing number of papers have suggested that the timing for oxidative continental weathering, and by conventional thinking the onset of atmospheric oxygenation, was hundreds of million years earlier than previously thought despite the presence of S-MIF. We suggest that this apparent discrepancy can be resolved by the earliest oxidative-weathering reactions occurring in benthic and soil environments at profound redox disequilibrium with the atmosphere, such as biological soil crusts and freshwater microbial mats covering riverbed, lacustrine, and estuarine sediments. We calculate that oxygenic photosynthesis in these millimeter-thick ecosystems provides sufficient oxidizing equivalents to mobilize sulfate and redox-sensitive trace metals from land to the oceans while the atmosphere itself remained anoxic with its attendant S-MIF signature. As continental freeboard increased significantly between 3.0 and 2.5 Ga, the chemical and isotopic signatures of benthic oxidative weathering would have become more globally significant from a mass-balance perspective. These observations help reconcile evidence for pre-GOE oxidative weathering with the history of atmospheric chemistry, and support the plausible antiquity of a terrestrial biosphere populated by cyanobacteria well before the GOE.

Fundamental spatial and temporal disconnections in the hydrology of an intermittent prairie headwater network

Summary We characterize the hydrology of intermittent prairie headwater streams of the Konza Prairie Biological Station (Konza) located in northeastern Kansas, USA. Flow records from four gaging stations were used to quantify flow intermittence and mean and peak annual discharges. Gage sites used in this analysis are classified as harshly intermittent with all sites having over 90 days of zero-flow annually. The largest basin had the fewest zero-flow days and the shortest durations of zero-flow while the smallest basin had the most zero-flow days and the highest frequency zero-flow durations. There were strong correlations between total annual precipitation and the total number of zero-flow days and the number of zero-flow periods. Correlations were less strong between the Palmer Drought Severity Index (PDSI) and the number of zero-flow days and between PDSI and the number of zero-flow periods. Basin-averaged total annual precipitation poorly predicted mean annual and peak annual discharges. Double mass plots of streamflow to precipitation and streamflow in the headwaters to the receiving stream demonstrate many instances of flow desynchronization. Results of this study suggest that local watershed-scale processes, such as groundwater storage in limestone and alluvial strata, dynamic infiltration flow paths, and soil moisture conditions, produce a threshold-driven hydrologic response, decoupling the headwater hydrologic regimes from sub-annual weather patterns.

Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases.

Francisella tularensis induces the synthesis of prostaglandin E(2) (PGE(2)) by infected macrophages to alter host immune responses, thus providing a survival advantage to the bacterium. We previously demonstrated that PGE(2) synthesis by F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2)), cyclooxygenase 2 (COX-2), and microsomal prostaglandin E synthase 1 (mPGES1). During inducible PGE(2) synthesis, cPLA(2) hydrolyzes arachidonic acid (AA) from cellular phospholipids to be converted to PGE(2). However, in F. tularensis-infected macrophages we observed a temporal disconnect between Ser505-cPLA(2) phosphorylation (a marker of activation) and PGE(2) synthesis. These results suggested to us that cPLA(2) is not responsible for the liberation of AA to be converted into PGE(2) by F. tularensis-infected macrophages. Utilizing small-molecule inhibitors, we demonstrated that phospholipase D and diacylglycerol lipase were required for providing AA for PGE(2) biosynthesis. cPLA(2), on the other hand, was required for macrophage cytokine responses to F. tularensis. We also demonstrated for the first time that lipin-1 and PAP2a contribute to macrophage inflammation in response to F. tularensis. Our results identify both an alternative pathway for inducible PGE(2) synthesis and a role for lipid-modifying enzymes in the regulation of macrophage inflammatory function.

Multiple thalamo-cortical disconnections in anterior thalamic infarction: Implications for thalamic mechanisms of memory and language

Amnesia and linguistic deficits that are associated with thalamic damage have attracted the attention of researchers interested in identifying the neural networks involved in memory and language. The Papez circuit, which is composed of the hippocampus, mammillary body and anterior thalamic nuclei, was first proposed to be critical for memory. However, subsequently, the roles of the neural circuit consisting of the rhinal/parahippocampal cortices and the mediodorsal thalamic nuclei became evident. The ventral lateral nuclei or its adjacent structures have been found to be involved in semantic processing, but the specific neural circuits dedicated to language functions have not been identified.Anterior thalamic infarcts, which affect very circumscribed regions of the ventral anterior portion of the thalamus, often cause paradoxically prominent memory and language deficits. We conducted tractography analyses in 6 patients with left anterior thalamic infarcts to identify neural connections or circuits in which disruptions are associated with memory and language deficits in this condition. The current study demonstrated that the mammillothalamic tract, which connects the mammillary body with the anterior thalamic nuclei, and the anterior and inferior thalamic peduncles, which contain neural fibers that extend from several thalamic nuclei to the anterior temporal, medial temporal and frontal cortices, are disrupted in anterior thalamic infarction. These extensive thalamo-cortical disconnections appear to be due to the dissection of the neural fibers that penetrate the ventral anterior nucleus of the thalamus. Our results suggest the following: (1) amnesia that is associated with anterior thalamic infarction is best interpreted in the context of dual/multiple-system theories of memory/amnesia that posit that multiple neural circuits connecting the anterior and mediodorsal thalamic nuclei with the hippocampus and rhinal/parahippocampal cortices work in concert to support memory function; and (2) the semantic deficits observed in this syndrome may be associated with thalamo-anterior temporal and thalamo-lateral frontal disconnections.

Impact of Hydropower Regulation on River Water Composition in Northern Sweden

Using hydrogeochemical analysis of two large boreal rivers (pristine Kalix and hydropower regulated Lule) discharging into the Gulf of Bothnia, the major impacts of regulation on water discharge, element transport and their seasonal redistribution have been assessed. The pre-regulation hydrogeochemical features were assumed to be similar for the two rivers. For the Lule River, the average maximum runoff was almost halved, while the average minimum was tripled as a result of the regulation. The fraction of winter transport of total organic carbon (TOC), Fe, Si, suspended Mn and P in the Lule River was, according to a conservative estimate, two to three times higher than in the pristine river. Longer residence time in the Lule River delayed arrival of the suspended Mn peak and dissolved Si decline to the river mouth. During summer, the suspended C/N ratio in the regulated river was 10–20 compared to <10 for the pristine, suggesting presence of predominantly old organic material. This was supported by a virtually constant suspended P/Fe ratio throughout the year in the Lule River, indicating low abundance of phytoplankton. TOC varied irregularly in the Lule River suggesting temporal disconnection between the river and the upper riparian zone. The disappearance of the spring flow maximum, a shift of element transport from spring to winter and supply of mainly old organic material during the vegetation growth season may have a pronounced impact on the ecosystem of the Gulf of Bothnia and the river itself.

Signaling stress? An analysis of phaeomelanin-based plumage color and individual corticosterone levels at two temporal scales in North American barn swallows, Hirundo rustica erythrogaster

Sexually selected traits confer greater reproductive benefits to individuals with more elaborate forms of the signal. However, whether these signals convey reliable information about the physiology underlying trait development remains unknown in many species. The steroid hormone corticosterone (CORT) mediates important physiological and behavioral processes during the vertebrate stress response, and CORT secretion itself can be modulated by melanocortins. Thus, sexually selected melanin-based plumage coloration could function as an honest signal of an individual's ability to respond to stressors. This hypothesis was tested in North American barn swallows, Hirundo rustica erythrogaster, where males with darker ventral plumage color exhibit higher phaeomelanin content and are more successful at reproduction. Because reproductive behavior occurs months after plumage signals are developed, we also addressed the potential temporal disconnect of physiological state during trait development and trait advertisement by analyzing three different measurements of CORT levels in adult males during the breeding season (trait advertisement) and in nestling males while they were growing their feathers (trait development). Variation in adult plumage color did not predict baseline or stress-induced CORT, or stress responsiveness. Likewise, there was no relationship between nestling plumage color and any of the CORT measurements, but heavier nestlings had significantly lower baseline CORT. Our finding that a predominantly phaeomelanin-based trait is unrelated to circulating CORT suggests that phaeomelanin and eumelanin signals may convey different physiological information, and highlights the need for further study on the biochemical links between the hypothalamic–pituitary–adrenal (HPA) axis and the production of different melanin-based pigments.