The identification of spatiotemporal changes in ecosystem service values (ESVs) and their drivers is the basis for ecosystem service administration and decision-making. This research focuses on the Yellow River Basin (YRB). With a multitemporal land use and land cover (LULC) dataset (1995-2018), the equivalence coefficient method with spatiotemporal dynamic correction and exploratory spatial data analysis methods were used to evaluate ESV changes due to LULC changes and their spatial characteristics. The contributions of the ESV driving factors and their mutual effects were also investigated via geographic detectors. The results revealed that (1) the land use structure of the YRB, mainly grassland and cultivated land, was stable from 1995 to 2018. However, the transition between land use types was dramatic, including urban expansion accompanied by losses of farmland, grassland, and unused land; increased forestland; and significant increases in water bodies and wetland areas. (2) During the study period, the overall ESV of the YRB increased, and hydrological regulation and climate regulation services dominated the change in the ESVs in the study area. The ESV exhibited obvious ecogeographical pattern differentiation and evident positive spatial autocorrelation. High values were concentrated in the southern part of the study area, including the southeastern part of the Qinghai-Tibet Plateau region and the central part of the East Asian monsoon region. Low values were concentrated in the northwestern arid zone, dominated by desert and grassland ecosystems. (3) Because of the fragility of the regional ecological background, the spatial differentiation of the ESVs in the YRB is dependent on natural factors; however, anthropogenic factors such as the degree of land use and the human activity intensity also lead to ESV differentiation. The synergistic effects of human activities, landscape pattern changes, and natural factors result in the spatial differentiation of the ESVs in the research region. Therefore, human activities affecting the ecological environment should be controlled, nature-based solutions should be advocated, patch diversity should be increased, landscape fragmentation should be reduced, LULC ecosystem service functions should be improved, and the relationship among economic, social, and ecological landscape resources should be coordinated.
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