Temporal Delay Research Articles

The temporal integration windows for visual mirror symmetry

Symmetry perception in dot patterns is tolerant to temporal delays of up to 60 ms within and between element pairs. However, it is not known how factors effecting symmetry discrimination in static patterns might affect temporal integration in dynamic patterns. One such feature is luminance polarity. Using dynamic stimuli with increasing temporal delay (SOA) between the onset of the first and second element in a symmetric pair, we investigated how four different luminance-polarity conditions affected the temporal integration of symmetric patterns. All four luminance polarity conditions showed similar upper temporal limits of approximately 60 ms. However psychophysical performance over all delay durations showed significantly higher symmetry thresholds for unmatched-polarity patterns at short delays, but also significantly less sensitivity to increasing temporal delay relative to matched-polarity patterns. These varying temporal windows are consistent with the involvement of a fast, sensitive first-order mechanism for matched-polarity patterns, and a slower, more robust second-order mechanism for unmatched-polarity patterns. Temporal integration windows for unmatched-polarity patterns were not consistent with performance expected from attentional mechanisms alone, and instead supports the involvement of second-order mechanisms that combines information from ON and OFF channels.

Effects of TNFα on Dynamic Cytosolic Ca2 + and Force Responses to Muscarinic Stimulation in Airway Smooth Muscle.

Previously, we reported that in airway smooth muscle (ASM), the cytosolic Ca2+ ([Ca2+]cyt) and force response induced by acetyl choline (ACh) are increased by exposure to the pro-inflammatory cytokine tumor necrosis factor α (TNFα). The increase in ASM force induced by TNFα was not associated with an increase in regulatory myosin light chain (rMLC20) phosphorylation but was associated with an increase in contractile protein (actin and myosin) concentration and an enhancement of Ca2+ dependent actin polymerization. The sensitivity of ASM force generation to elevated [Ca2+]cyt (Ca2+ sensitivity) is dynamic involving both the shorter-term canonical calmodulin-myosin light chain kinase (MLCK) signaling cascade that regulates rMLC20 phosphorylation and cross-bridge recruitment as well as the longer-term regulation of actin polymerization that regulates contractile unit recruitment and actin tethering to the cortical cytoskeleton. In this study, we simultaneously measured [Ca2+]cyt and force responses to ACh and explored the impact of 24-h TNFα on the dynamic relationship between [Ca2+]cyt and force responses. The temporal delay between the onset of [Ca2+]cyt and force responses was not affected by TNFα. Similarly, the rates of rise of [Ca2+]cyt and force responses were not affected by TNFα. The absence of an impact of TNFα on the short delay relationships between [Ca2+]cyt and force was consistent with the absence of an effect of [Ca2+]cyt and force on rMLC20 phosphorylation. However, the integral of the phase-loop plot of [Ca2+]cyt and force increased with TNFα, consistent with an impact on actin polymerization and, contractile unit recruitment and actin tethering to the cortical cytoskeleton.

Distribution of Responsibility for Climate Change within the Milieu

This article approaches the challenges of the distribution of responsibility for climate change on a local level using the framework of the milieu. It suggests that the framework of the milieu, inspired by Japanese and cross-cultural environmental philosophy, provides pathways to address the four challenges of climate change (global dispersion, fragmentation of agency, institutional inadequacy, temporal delay). The framework of the milieu clarifies the interrelations between the individual, the community, and the local milieu and is open to a conservative view of human communities and an inclusive view of multispecies communities. On this basis, an account of individual responsibility that is anchored in the local milieu and includes a responsibility to collaborate across milieus is developed. It consists of a forward-looking responsibility that balances a degree of contributory responsibility for one’s imprints on the milieu with a degree of capacity-responsibility that varies regarding the individual’s knowledge and powers, and the acceptability of practices within the local milieu.

Training at asymptote stabilizes motor memories by reducing intracortical excitation

Learning similar motor skills in close succession is limited by interference, a phenomenon that takes place early after acquisition when motor memories are unstable. Interference can be bidirectional, as the first memory can be disrupted by the second (retrograde interference), or the second memory can be disrupted by the first (anterograde interference). The heightened plastic state of primary motor cortex after learning is thought to underlie interference, as unstable motor memories compete for neural resources. While time-dependent consolidation processes reduce interference, the passage of time (~6 h) required for memory stabilization limits our capacity to learn multiple motor skills at once. Here, we demonstrate in humans that prolonged training at asymptote of an initial motor skill reduces both retrograde and anterograde interference when a second motor skill is acquired in close succession. Neurophysiological assessments via transcranial magnetic stimulation reflect this online stabilization process. Specifically, excitatory neurotransmission in primary motor cortex increased after short training and decreased after prolonged training at performance asymptote. Of note, this reduction in intracortical excitation after prolonged training was proportional to better skill retention the following day. Importantly, these neurophysiological effects were not observed after motor practice without learning or after a temporal delay. Together, these findings indicate that prolonged training at asymptote improves the capacity to learn multiple motor skills in close succession, and that downregulation of excitatory neurotransmission in primary motor cortex may be a marker of online motor memory stabilization.

The utility of biochar for increasing the fertility of new agricultural lands converted from boreal forests

The agricultural soils of the Happy Valley-Goose Bay (HV-GB) region of Newfoundland and Labrador, Canada are Podzols that are converted from boreal forest and have limited productivity due to their sandy texture, acidity, low soil organic matter (SOM), cation-exchange capacity (CEC), and water and nutrient retention capacity. Although numerous studies advocate biochar for mitigating soil quality problems and enhancing agronomic productivity, there is limited information on managing biochar for boosting the productivity of Podzols under newly converted agricultural lands. A 5 year experiment evaluated the impact of eight biochar rates (0–80 Mg C·ha−1) on soil properties including SOM, CEC, and availability of plant nutrients and metals in agricultural soils of HV-GB. Both immediate and long-term impacts were thus assessed. Biochar generally improved soil fertility indicators. Although the largest rates (40 and 80 Mg C·ha−1) led to the greatest changes, significant changes were also found with rates as low as 10 Mg C·ha−1. Increasing biochar rates had diminishing returns for quality parameters of soil. The impact of biochar decreased with time after application, but the largest rate led to longer lasting effects. Although biochar was incorporated in topsoil, its effects were also measurable in the subsoil, albeit with a temporal delay, usually of 1 year. Thus, given the diminishing returns of increasing biochar rates, and that beneficial effects diminish over years, it is advisable that biochar be added in smaller amounts immediately after conversion, as little as 10 Mg C·ha−1, with regular supplementation as needed.

Pathways control in modification of solid surfaces induced by temporarily separated femtosecond laser pulses

Reaction control by laser light is a unique method of the reaction dynamics mastery in the molecular chemistry. We provide evidence of phase control processing with femtosecond lasers in macroscopic solids. Rutile TiO2 monocrystals with (001) and (100) surface orientations were irradiated with repetitive pulses of femtosecond KrF laser of variable fluences and a temporal delay between two superimposed linearly polarized beams. The appearance of three types of surface morphology was thoroughly analyzed: low-spatial frequency laser-induced periodic surface structures (LSFL), grooves and unusual featureless flat area (FFA). The interaction of light with the excited surface led to the onset or suppression of the subwavelength LSFL, depending on whether the temporal delay between laser beams is larger or smaller than the critical value of ~6 ps. By contrast, the suprawavelength grooves and FFA appeared at longer temporal delays. A strong decrease of the grooves onset energy was observed on the (001) oriented crystal after the delay of ~8 ps; the decrease of onset energy was also observed on the (100) oriented crystal, where FFA appeared instead of grooves. The critical delay is discussed in framework of a phenomenological model describing the energy evolution of excited transient states along the “reaction” coordinate.

The use of a portable black light (UV-A) flashlight to aid in biopsy site identification

Patients with biopsy-proven skin cancers require definitive treatment. As a result of healing, the temporal delay between the time of biopsy and treatment, and lack of standardized information sharing if the patient is referred to another provider, there is a risk that the biopsy site may be incorrectly identified. Other challenges include multiple lesions in an anatomic area, location in a place not visible to the patient, and proximity to other scars. In 1 study of 150 dermatologists who self-reported medical errors, wrong-site surgery was the most common “serious error.”1 In another study of 333 consecutive patients undergoing Mohs surgery, 9% were unable to identify their biopsy site.

Linear dichroism in few-photon ionization of laser-dressed helium

Ionization of laser-dressed atomic helium is investigated with focus on photoelectron angular distributions stemming from two-color multi-photon excited states. The experiment combines extreme ultraviolet (XUV) with infrared (IR) radiation, while the relative polarization and the temporal delay between the pulses can be varied. By means of an XUV photon energy scan over several electronvolts, we get access to excited states in the dressed atom exhibiting various binding energies, angular momenta, and magnetic quantum numbers. Furthermore, varying the relative polarization is employed as a handle to switch on and off the population of certain states that are only accessible by two-photon excitation. In this way, photoemission can be suppressed for specific XUV photon energies. Additionally, we investigate the dependence of the photoelectron angular distributions on the IR laser intensity. At our higher IR intensities, we start leaving the simple multi-photon ionization regime. The interpretation of the experimental results is supported by numerically solving the time-dependent Schrödinger equation in a single-active-electron approximation.Graphic abstract

Comparative Analysis of HLLC- and Roe-Based Models for the Simulation of a Dam-Break Flow in an Erodible Channel with a 90∘ Bend

In geophysical surface flows, the sediment particles can be transported under capacity (equilibrium) conditions or noncapacity (nonequilibrium) conditions. On the one hand, the equilibrium approach for the bedload transport assumes that the actual transport rate instantaneously adapts to the local flow features. The resulting system of equations, composed of the shallow water equations for the flow (SWE) and the Exner equation for the bed evolution, has been widely used to simulate bedload processes. These capacity SWE + Exner models are highly dependent on the setup parameters, so that the calibration procedure often disguises the advantages and flaws of the numerical method. On the other hand, noncapacity approaches account for the temporal and spatial delay of the actual sediment transport rate with respect to the capacity of the flow. The importance of assuming nonequilibrium conditions in bedload numerical models remains uncertain however. In this work, we compared the performances of three different strategies for the resolution of the SWE + Exner system under capacity and noncapacity conditions to approximate a set of experimental data with fixed setup parameters. The results indicate that the discrete strategy used to compute the intercell fluxes significantly affected the solution. Furthermore, the noncapacity approach can improve the model prediction in regions with complex transient processes, but it requires a careful calibration of the nonequilibrium parameters.

Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.

Stem cells (SCs) play a key role in homeostasis and repair. While many studies have focused on SC self-renewal and differentiation, little is known regarding the molecular mechanism regulating SC elimination and compensation upon loss. Here, we report that Caspase-9 deletion in hair follicle SCs (HFSCs) attenuates the apoptotic cascade, resulting in significant temporal delays. Surprisingly, Casp9-deficient HFSCs accumulate high levels of cleaved caspase-3 and are improperly cleared due to an essential caspase-3/caspase-9 feedforward loop. These SCs are retained in an apoptotic-engaged state, serving as mitogenic signaling centers by continuously releasing Wnt3 and instructing proliferation. Investigating the underlying mechanism, we reveal a caspase-3/Dusp8/p38 module responsible for Wnt3 induction, which operates in both normal and Casp9-deleted HFSCs. Notably, Casp9-deleted mice display accelerated wound repair and de novo hair follicle regeneration. Taken together, we demonstrate that apoptotic cells represent a dynamic SC niche, from which emanating signals drive SC proliferation and tissue regeneration.

The role of action effects in motor sequence planning and execution: exploring the influence of temporal and spatial effect anticipation

Actions we perform every day generate perceivable outcomes with both spatial and temporal features. According to the ideomotor principle, we plan our actions by anticipating the outcomes, but this principle does not directly address how sequential movements are influenced by different outcomes. We examined how sequential action planning is influenced by the anticipation of temporal and spatial features of action outcomes. We further explored the influence of action sequence switching. Participants performed cued sequences of button presses that generated visual effects which were either spatially compatible or incompatible with the sequences, and the spatial effects appeared after a short or long delay. The sequence cues switched or repeated across trials, and the predictability of action sequence switches was varied across groups. The results showed a delay-anticipation effect for sequential action, whereby a shorter anticipated delay between action sequences and their outcomes speeded initiation and execution of the cued action sequences. Delay anticipation was increased by predictable action switching, but it was not strongly modified by the spatial compatibility of the action outcomes. The results extend previous demonstrations of delay anticipation to the context of sequential action. The temporal delay between actions and their outcomes appears to be retrieved for sequential planning and influences both the initiation and the execution of actions.

Action-locked Neural Responses in Auditory Cortex to Self-generated Sounds.

Sensory perception is a product of interactions between the internal state of an organism and the physical attributes of a stimulus. It has been shown across the animal kingdom that perception and sensory-evoked physiological responses are modulated depending on whether or not the stimulus is the consequence of voluntary actions. These phenomena are often attributed to motor signals sent to relevant sensory regions that convey information about upcoming sensory consequences. However, the neurophysiological signature of action-locked modulations in sensory cortex, and their relationship with perception, is still unclear. In the current study, we recorded neurophysiological (using Magnetoencephalography) and behavioral responses from 16 healthy subjects performing an auditory detection task of faint tones. Tones were either generated by subjects' voluntary button presses or occurred predictably following a visual cue. By introducing a constant temporal delay between button press/cue and tone delivery, and applying source-level analysis, we decoupled action-locked and auditory-locked activity in auditory cortex. We show action-locked evoked-responses in auditory cortex following sound-triggering actions and preceding sound onset. Such evoked-responses were not found for button-presses that were not coupled with sounds, or sounds delivered following a predictive visual cue. Our results provide evidence for efferent signals in human auditory cortex that are locked to voluntary actions coupled with future auditory consequences.

Inductive learning of answer set programs for autonomous surgical task planning

The quality of robot-assisted surgery can be improved and the use of hospital resources can be optimized by enhancing autonomy and reliability in the robot’s operation. Logic programming is a good choice for task planning in robot-assisted surgery because it supports reliable reasoning with domain knowledge and increases transparency in the decision making. However, prior knowledge of the task and the domain is typically incomplete, and it often needs to be refined from executions of the surgical task(s) under consideration to avoid sub-optimal performance. In this paper, we investigate the applicability of inductive logic programming for learning previously unknown axioms governing domain dynamics. We do so under answer set semantics for a benchmark surgical training task, the ring transfer. We extend our previous work on learning the immediate preconditions of actions and constraints, to also learn axioms encoding arbitrary temporal delays between atoms that are effects of actions under the event calculus formalism. We propose a systematic approach for learning the specifications of a generic robotic task under the answer set semantics, allowing easy knowledge refinement with iterative learning. In the context of 1000 simulated scenarios, we demonstrate the significant improvement in performance obtained with the learned axioms compared with the hand-written ones; specifically, the learned axioms address some critical issues related to the plan computation time, which is promising for reliable real-time performance during surgery.

Targeted memory reactivation has a sleep stage-specific delayed effect on dream content.

Although new learning is known to reappear in later dream scenarios, the timing of such reappearances remains unclear. Sometimes, references to new learning occur relatively quickly, 1day post-learning (day-residue effect); at other times there may be a substantive delay, 5-7days, before such references appear (dream-lag effect). We studied temporal delays in dream reactivation following the learning of a virtual reality (VR) flying task using 10-day home sleep/dream logs, and how these might be influenced by targeted memory reactivation (TMR). Participants were exposed twice to a VR task in the sleep laboratory; once before and once after a 2-hr opportunity to nap (n=65) or to read (n=32). Auditory cues associated with the VR task were replayed in either wake, rapid eye movement (REM) sleep, slow-wave sleep (SWS) or were not replayed. Although we previously showed that TMR cueing did not have an immediate effect on dream content, in the present study we extend these results by showing that TMR in sleep has instead a delayed effect on task-dream reactivations: participants dreamed more about the task 1-2days later when TMR was applied in REM sleep and 5-6days later when it was applied in SWS sleep, compared to participants with no cueing. Findings may help explain the temporal relationships between dream and memory reactivations and clarify the occurrence of day-residue and dream-lag phenomena.

Investigation of supercontinuum generation in photonic crystal fiber using bursts of femtosecond pulses

Results of experimental and numerical investigation of supercontinuum generation in polarization maintaining photonic crystal fiber using a burst of two orthogonal polarization femtosecond pump pulses are presented. The initial pump pulse source was a mode-locked Yb:KGW laser generating 52 nJ energy 90 fs duration pulses at 1033 nm with 76 MHz repetition rate. Analysis of cross-correlation frequency-resolved optical gating traces and numerical simulation results reveal that there are slight changes in supercontinuum generation when temporal delay between pump pulses in the burst is changed. Weak dependence of supercontinuum characteristics on temporal distance between the pump pulses is related to supercontinuum generation dynamics which is analyzed in detail.

Endometrial delay is found to be part of a normal individual dynamic transformation process

PurposeLimited information is clinically available concerning endometrial receptivity; assessing endometrial transformation status is therefore an urgent topic in assisted reproductive technology. This study aimed to investigate individual endometrial transformation rates during the secretory phase in subfertile patients using personal endometrial transformation analysis.MethodsMonitoring was carried out during the secretory phase to obtain endometrial receptivity profiles. For the investigation, two endometrial biopsies were taken within one menstrual cycle. The extended endometrial dating was based on the Noyes criteria, combined with immunohistochemical analyses of hormone receptors and proliferation marker Ki-67. Biopsies were taken mainly at days ovulation (OV, n = 76)/hormone replacement therapy (HRT, n = 58) + 5 and + 10.ResultsThe results of the two biopsies were correlated with the clinically expected day of the cycle and showed temporal delays or hypercompensations, diverging from the expected cycle days by 0.5–5 days. In comparison with the first biopsies, the transformation rate in the second biopsies showed compensation, augmented delay, or constant transformation in 48.69, 22.37, and 28.94% of cases for ovulation in natural cycles and 56.89, 25.85, and 17.26% for HRT cycles, respectively.ConclusionThe study revealed an individually dynamic transformation process of the endometrium, with the ability to compensate or enlarge an initial “delay”, which is now identified as a normal individual transformation process during the secretory phase. This information is of great importance for the scientific investigation of dynamic changes in endometrial tissue, as well as for the timing of embryo transfers.

Reducing Implicit Cognitive Biases Through the Performing Arts

The aim of the present research was to test whether involvement in a 14-days training program in the performing arts could reduce implicit biases. We asked healthy participants to complete an Implicit Association Test (IAT) to assess biased attitudes to physical illness in two separate sessions, before and after the training program. Two separate control groups matched by age, gender and educational level completed the two IAT sessions, separated by same number of days, without being involved in the training program. Results showed that participants who were involved in the training program reduced their implicit bias toward illness measured through IAT in the second session. This reduction in IAT measures was not observed in the control samples, despite the two IAT measures being matched in temporal delay with the experimental group. These findings suggest that an interventional program based on the performing arts could be effective in reducing levels of implicit biases among the general population.

Delaying two-photon Fock states in hot cesium vapor using single photons generated on demand from a semiconductor quantum dot

Single photons from solid-state quantum emitters are playing a crucial role in the development of photonic quantum technologies. Higher order states, such as N-photon Fock-states allow for applications e.g. in quantum-enhanced sensing. In this study, we utilize the dispersion of a hot cesium vapor at the D1 lines to realize a temporal delay for one and two-photon Fock-states as a result of the slow-light effect. Single photons are generated on-demand from an InGaAs quantum dot, while their quantum interference at a beam splitter is used to generate a two-photon Fockstate. We verify the successful propagation and temporal delay of both the one and two-photon Fock-states, while a significant delay (5x initial photon length) with simultaneous high transmission (~90 %) is achieved.

Adaptive optics control using model-based reinforcement learning.

Reinforcement learning (RL) presents a new approach for controlling adaptive optics (AO) systems for Astronomy. It promises to effectively cope with some aspects often hampering AO performance such as temporal delay or calibration errors. We formulate the AO control loop as a model-based RL problem (MBRL) and apply it in numerical simulations to a simple Shack-Hartmann Sensor (SHS) based AO system with 24 resolution elements across the aperture. The simulations show that MBRL controlled AO predicts the temporal evolution of turbulence and adjusts to mis-registration between deformable mirror and SHS which is a typical calibration issue in AO. The method learns continuously on timescales of some seconds and is therefore capable of automatically adjusting to changing conditions.

Dependence of Neuronal Network Structure on Event-Related Desynchronization Caused by Light Stimulation

Previous experiments have shown that neural population structure in the cerebral cortex affects cognitive function. However, it is unclear how the activity of the neural population is involved between them. In this study, we compared the relationship between the structure and activity of neural populations in the primary visual cortex. Intracellular volume fraction obtained by NODDI analysis of diffusion-weighted MRI was used as an indicator of neural population structure. The temporal delay in change of alpha wave intensity on event-related desynchronization in response to light stimuli was also used as an indicator of neural population activity. Using the stochastic oscillation mathematical model, we simulated event-related desynchronization and measured delay in change of alpha wave intensity when the coupling probability is changed on the model. The results showed that delay in attenuation of alpha wave intensity was smaller and delay in recovery was greater in both cases measurement and simulation, given higher neuron density. In conclusion, it is clear that structural features of the neuronal population affect the collective activity and that such phenomenon can be explained by mathematical models.